Coronavirus infections and immune responses.
Geng Li,Geng Li,Yaohuao Fan,Yanni Lai,Tiantian Han,Zonghui Li,Peiwen Zhou,Pan Pan,Wenbiao Wang,Dingwen Hu,Xiaohong Liu,Qiwei Zhang,Qiwei Zhang,Jianguo Wu,Jianguo Wu +14 more
TLDR
An update on CoV infections and relevant diseases, particularly the host defense against CoV‐induced inflammation of lung tissue, as well as the role of the innate immune system in the pathogenesis and clinical treatment is provided.Citations
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Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and coronavirus disease-2019 (COVID-19): The epidemic and the challenges.
TL;DR: Among patients with pneumonia caused by SARS-CoV-2 (novel coronavirus pneumonia or Wuhan pneumonia), fever was the most common symptom, followed by cough, and bilateral lung involvement with ground-glass opacity was themost common finding from computed tomography images of the chest.
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Rapid Detection of COVID-19 Causative Virus (SARS-CoV-2) in Human Nasopharyngeal Swab Specimens Using Field-Effect Transistor-Based Biosensor.
Giwan Seo,Geonhee Lee,Mi-Jeong Kim,Seung Hwa Baek,Minsuk Choi,Keun Bon Ku,Chang-Seop Lee,Sangmi Jun,Daeui Park,Hong Gi Kim,Seong-Jun Kim,Jeong O. Lee,Bum Tae Kim,Edmond Changkyun Park,Seung Il Kim +14 more
TL;DR: The FET sensor fabricated here is a highly sensitive immunological diagnostic method for COVID-19 that requires no sample pretreatment or labeling and is a promising FET biosensor for SARS-CoV-2.
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Expression of the SARS-CoV-2 cell receptor gene ACE2 in a wide variety of human tissues.
TL;DR: The data indicate that SARS-CoV-2 may infect other tissues aside from the lungs and infect persons with different sexes, ages, and races equally, and may partially explain why males and females, young and old persons infected with this virus have markedly distinct disease severity.
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Epidemiological, clinical and virological characteristics of 74 cases of coronavirus-infected disease 2019 (COVID-19) with gastrointestinal symptoms.
Xi Jin,Jiangshan Lian,Jianhua Hu,Jianguo Gao,Lin Zheng,Yimin Zhang,Shaorui Hao,Hongyu Jia,Huan Cai,Xiaoli Zhang,Guodong Yu,Kaijin Xu,Xiaoyan Wang,Jueqing Gu,Shanyan Zhang,Chanyuan Ye,Ciliang Jin,Yingfeng Lu,Xia Yu,Xiaopeng Yu,Jianrong Huang,Kangli Xu,Qin Ni,Chengbo Yu,Biao Zhu,Yongtao Li,Jun Liu,Hong Zhao,Xuan Zhang,Liang Yu,Yongzheng Guo,Junwei Su,Jingjing Tao,Guanjing Lang,Xiaoxin Wu,Wenrui Wu,Ting-Ting Qv,Dairong Xiang,Ping Yi,Ding Shi,Yanfei Chen,Yue Ren,Yunqing Qiu,Lanjuan Li,Jifang Sheng,Yida Yang +45 more
TL;DR: Attention to patients with COVID-19 with non-classic symptoms should increase to protect health providers, and sequence mutation of SARS-CoV-2 with m6A methylation and changed binding capacity with ACE2 was showed.
Journal ArticleDOI
Coronavirus Disease 2019–COVID-19
Kuldeep Dhama,Khan Sharun,Ruchi Tiwari,Shubhankar Sircar,Sudipta Bhat,Yashpal Singh Malik,Karam Pal Singh,Wanpen Chaicumpa,D. Katterine Bonilla-Aldana,Alfonso J. Rodriguez-Morales +9 more
TL;DR: Analysis of epidemiological, diagnostic, clinical, and therapeutic aspects, including perspectives of vaccines and preventive measures that have already been globally recommended to counter this pandemic virus, suggest that this novel virus has been transferred from an animal source, such as bats.
References
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Pathogen Recognition and Innate Immunity
TL;DR: New insights into innate immunity are changing the way the way the authors think about pathogenesis and the treatment of infectious diseases, allergy, and autoimmunity.
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The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors
Taro Kawai,Shizuo Akira +1 more
TL;DR: Recent advances that have been made by research into the role of TLR biology in host defense and disease are described.
Journal ArticleDOI
Pattern Recognition Receptors and Inflammation
Osamu Takeuchi,Shizuo Akira +1 more
TL;DR: The role of PRRs, their signaling pathways, and how they control inflammatory responses are discussed.
Journal ArticleDOI
A Toll-like receptor recognizes bacterial DNA.
Hiroaki Hemmi,Osamu Takeuchi,Taro Kawai,Tsuneyasu Kaisho,Shintaro Sato,Hideki Sanjo,Makoto Matsumoto,Katsuaki Hoshino,Hermann Wagner,Kiyoshi Takeda,Shizuo Akira +10 more
TL;DR: It is shown that cellular response to CpG DNA is mediated by a Toll-like receptor, TLR9, and vertebrate immune systems appear to have evolved a specific Toll- like receptor that distinguishes bacterial DNA from self-DNA.
Journal ArticleDOI
Cyclic GMP-AMP Synthase is a Cytosolic DNA Sensor that Activates the Type-I Interferon Pathway
TL;DR: Results indicate that cGAS is a cytosolic DNA sensor that induces interferons by producing the second messenger cGAMP, which belongs to the nucleotidyltransferase family.
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