Correlation between in vitro and in vivo immunomodulatory properties of lactic acid bacteria
Benoît Foligné,Sophie Nutten,Corinne Grangette,Véronique Dennin,Denise Goudercourt,Sabine Poiret,Joëlle Dewulf,Dominique Brassart,Annick Mercenier,Bruno Pot +9 more
TLDR
Results show that the in vivo protective capacity of the studied lactic acid bacteria (LAB) could be predicted based on the cytokine profile established in vitro, and the PBMC-based assay used may serve as a useful primary indicator to narrow down the number of candidate strains to be tested in murine models for their anti-inflammatory potential.Abstract:
Correlation between in vitro and in vivo immunomodulatory properties of lactic acid bacteriaread more
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The gut microbiota shapes intestinal immune responses during health and disease
TL;DR: Findings indicating that developmental aspects of the adaptive immune system are influenced by bacterial colonization of the gut are discussed, and the possibility that the mammalian immune system, which seems to be designed to control microorganisms, is in fact controlled by microorganisms is raised.
Journal ArticleDOI
Faecalibacterium prausnitzii is an anti-inflammatory commensal bacterium identified by gut microbiota analysis of Crohn disease patients
Harry Sokol,Bénédicte Pigneur,Laurie Watterlot,Omar Lakhdari,Luis G. Bermúdez-Humarán,Jean-Jacques Gratadoux,Sébastien Blugeon,Chantal Bridonneau,Jean-Pierre Furet,Gérard Corthier,Corinne Grangette,Nadia Vasquez,Philippe Pochart,Germain Trugnan,Ginette Thomas,Hervé M. Blottière,Joël Doré,Philippe Marteau,Philippe Seksik,Philippe Langella +19 more
TL;DR: The results suggest that counterbalancing dysbiosis using F. prausnitzii as a probiotic is a promising strategy in CD treatment and exhibits anti-inflammatory effects on cellular and TNBS colitis models, partly due to secreted metabolites able to block NF-κB activation and IL-8 production.
Journal ArticleDOI
Emerging molecular insights into the interaction between probiotics and the host intestinal mucosa
TL;DR: Genomic approaches and nutrigenomic analyses have identified several bacterial factors that are involved in modulation of the immune system and the mucosal barrier, and have revealed that a molecular 'bandwidth of human health' could represent a key determinant in an individual's physiological responsiveness to probiotics.
Journal ArticleDOI
Probiotics and immunity
Andrea T. Borchers,Carlo Selmi,Carlo Selmi,Frederick J. Meyers,Carl L. Keen,M. Eric Gershwin +5 more
TL;DR: Promising results have been obtained with probiotics in the treatment of human inflammatory diseases of the intestine and in the prevention and treatment of atopic eczema in neonates and infants, however, the findings are too variable to allow firm conclusions as to the effectiveness of specific Probiotics in these conditions.
Journal ArticleDOI
Role of intestinal microbiota and metabolites on gut homeostasis and human diseases
Lan Lin,Jianqiong Zhang +1 more
TL;DR: A better understanding of the mutual interactions of the microbiota and host immune system, would shed light on the endeavors of disease prevention and broaden the path to the discovery of immune intervention targets for disease treatment.
References
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Wolfgang Kruis,Fric P,J Pokrotnieks,Milan Lukas,B Fixa,M Kaščák,Michael A. Kamm,J Weismueller,Christoph Beglinger,M Stolte,C Wolff,J Schulze +11 more
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Paolo Gionchetti,Fernando Rizzello,Ulf Helwig,A. Venturi,Karen M. Lammers,Patrizia Brigidi,Beatrice Vitali,Gilberto Poggioli,Mario Miglioli,Massimo Campieri +9 more
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Lactobacilli Differentially Modulate Expression of Cytokines and Maturation Surface Markers in Murine Dendritic Cells
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Faecalibacterium prausnitzii is an anti-inflammatory commensal bacterium identified by gut microbiota analysis of Crohn disease patients
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