Journal ArticleDOI
Cross talk between activation of microglia and astrocytes in pathological conditions in the central nervous system.
TLDR
A better understanding about the cross talk between activation of microglia and astrocytes would be helpful to elucidate the role of glial cells in pathological conditions, which could accelerate the development of treatment for various diseases.About:
This article is published in Life Sciences.The article was published on 2011-08-01. It has received 250 citations till now. The article focuses on the topics: Neuroinflammation & Microglia.read more
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Glia and epilepsy: excitability and inflammation
TL;DR: This review critically evaluates the role of glia-induced hyperexcitability and inflammation in epilepsy and points to a significant contribution by non-neuronal cells, the glia--especially astrocytes and microglia--in the pathophysiology of epilepsy.
Journal ArticleDOI
Blood-brain barrier pathophysiology in traumatic brain injury.
TL;DR: The BBB breakdown in TBI, the role of blood-borne factors in affecting the function of the gliovascular unit, changes in BBB permeability and post-traumatic edema formation, and the major pathophysiological factors associated with TBI that may contribute to post- traumatic dysfunction of the BBB are addressed.
Journal ArticleDOI
Sequential activation of microglia and astrocyte cytokine expression precedes increased Iba-1 or GFAP immunoreactivity following systemic immune challenge.
TL;DR: Induction of glial cytokine expression was sequential, aligned with active sickness behavior, and preceded increased Iba‐1 or GFAP immunoreactivity after LPS challenge, and did not correlate with morphology after four repeated LPS injections.
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Immune-mediated Mechanisms in the Pathoprogression of Amyotrophic Lateral Sclerosis
TL;DR: The importance of immune-mediated mechanisms in the pathogenesis of ALS is underscored and the alterations and distinct phenotypes of immune cells at the different stages of disease are discussed.
Journal ArticleDOI
Dual Functions of Microglia in Ischemic Stroke
Chuan Qin,Luo Qi Zhou,Xiao Tong Ma,Zi Wei Hu,Sheng Yang,Man Chen,Dale B. Bosco,Long Jun Wu,Dai Shi Tian +8 more
TL;DR: It is suggested that microglial activation is also critical for neurogenesis, angiogenesis, and synaptic remodeling, thereby promoting functional recovery after cerebral ischemia and the possible mechanisms controlling the post-ischemic activity of microglia.
References
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Journal ArticleDOI
Resting Microglial Cells Are Highly Dynamic Surveillants of Brain Parenchyma in Vivo
TL;DR: Using in vivo two-photon imaging in neocortex, it is found that microglial cells are highly active in their presumed resting state, continually surveying their microenvironment with extremely motile processes and protrusions.
Journal ArticleDOI
Microglia: a sensor for pathological events in the CNS
TL;DR: An understanding of intercellular signalling pathways for microglia proliferation and activation could form a rational basis for targeted intervention on glial reactions to injuries in the CNS.
Journal ArticleDOI
ATP mediates rapid microglial response to local brain injury in vivo
Dimitrios Davalos,Jaime Grutzendler,Jaime Grutzendler,Guang Yang,Jiyun Kim,Yi Zuo,Steffen Jung,Dan R. Littman,Michael L. Dustin,Wen-Biao Gan +9 more
TL;DR: Extracellular ATP regulates microglial branch dynamics in the intact brain, and its release from the damaged tissue and surrounding astrocytes mediates a rapid microglia response towards injury.
Journal ArticleDOI
Glutamate induces calcium waves in cultured astrocytes: long-range glial signaling
TL;DR: It is reported that cultured hippocampal astrocytes can respond to glutamate with a prompt and oscillatory elevation of cytoplasmic free calcium, visible through use of the fluorescent calcium indicator fluo-3.
Journal ArticleDOI
Perivascular microglial cells of the CNS are bone marrow-derived and present antigen in vivo.
TL;DR: Rat bone marrow chimeras and encephalitogenic, major histocompatability--restricted T-helper lymphocytes were used to show that a subset of endogenous CNS cells, commonly termed "perivascular microglial cells," is bone marrow-derived and are fully competent to present antigen to lymphocytes in an appropriately restricted manner.
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Shane A. Liddelow,Kevin A. Guttenplan,Laura E. Clarke,Frederick C. Bennett,Christopher J. Bohlen,Lucas Schirmer,Mariko L. Bennett,Alexandra E. Münch,Won-Suk Chung,Todd C. Peterson,Daniel K. Wilton,Arnaud Frouin,Brooke A. Napier,Nikhil Panicker,Manoj Kumar,Marion S. Buckwalter,David H. Rowitch,Valina L. Dawson,Ted M. Dawson,Beth Stevens,Ben A. Barres +20 more