Journal ArticleDOI
Cucurbituril chemistry: a tale of supramolecular success
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TLDR
Cucurbit[n]urils have become key units in various self-organizing and stimulus-controlled assemblies, as well as in advanced materials and drug carriers.Abstract:
This review highlights the past six year advances in the blossoming field of cucurbit[n]uril chemistry. Because of their exceptional recognition properties in aqueous medium, these pumpkin-shaped macrocycles have been generating some tremendous interest in the supramolecular community. They have also become key units in various self-organizing and stimulus-controlled assemblies, as well as in advanced materials and drug carriers. The scope of this review is limited to the main family of cucurbit[n]urils (n = 5, 6, 7, 8, 10). The reader will find an overview of their preparation, their physicochemical and biological properties, as well as their recognition abilities towards various organic and inorganic guests. Detailed thermodynamic and kinetic considerations, as well as multiple applications including supramolecular catalysis are also discussed.read more
Citations
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Journal ArticleDOI
Carbohydrates in Supramolecular Chemistry
TL;DR: It is revealed that carbohydrates are useful building blocks for the stabilization of complex architectures based on carbohydrate-protein interactions and other weak interactions such as π-π interactions.
Journal ArticleDOI
Synthesis and Self-Assembly Processes of Monofunctionalized Cucurbit[7]uril
Brittany Vinciguerra,Liping Cao,Joe R. Cannon,Peter Y. Zavalij,Catherine Fenselau,Lyle Isaacs +5 more
TL;DR: CB[7] derivatives bearing reactive functional groups (e.g., N3, Cl) are now available for incorporation into more complex functional systems and undergoes self-assembly to form a cyclic tetrameric assembly in aqueous solution.
Journal ArticleDOI
Mesoporous Silica Nanoparticles Coated by Layer-by-Layer Self-assembly Using Cucurbit[7]uril for in Vitro and in Vivo Anticancer Drug Release
Qing-Lan Li,Yanfang Sun,Yulong Sun,Ji-Jie Wen,Yue Zhou,Qi-Ming Bing,Lyle Isaacs,Yinghua Jin,Hui Gao,Ying-Wei Yang +9 more
TL;DR: Biocompatible layer-by-layer (LbL) coated MSNs that are designed and crafted to release encapsulated anticancer drugs, e.g., doxorubicin hydrochloride (DOX), by changing the pH or by adding competitive agents hold great potentials in anticancer drug delivery.
Journal ArticleDOI
Cucurbituril: A promising organic building block for the design of coordination compounds and beyond
TL;DR: The main types of coordination compounds in which cucurbiturils act as functional organic building blocks and interact with a wide range of metal ions through the portal carbonyl oxygen atoms have been summarized in this article.
Journal ArticleDOI
Insights into metalloenzyme microenvironments: biomimetic metal complexes with a functional second coordination sphere.
TL;DR: An overview of recent progress in non-covalent interactions in the second coordination sphere of metalloenzymes is provided and an introduction to native metall Koenzymes with an emphasis on thesecond coordination sphere is given.
References
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Journal ArticleDOI
Complexation Thermodynamics of Cyclodextrins.
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The cucurbit[n]uril family
TL;DR: In 1981, the macrocyclic methylene-bridged glycoluril hexamer (CB[6]) was dubbed "cucurbituril" by Mock and co-workers because of its resemblance to the most prominent member of the cucurbitaceae family of plants--the pumpkin.
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Cucurbituril homologues and derivatives: new opportunities in supramolecular chemistry.
TL;DR: This Account is a compilation of recent literature covering the syntheses of the homologues and derivatives, and their supramolecular chemistry of cucurbituril, a synthetic receptor.
Journal ArticleDOI
New Cucurbituril Homologues: Syntheses, Isolation, Characterization, and X-ray Crystal Structures of Cucurbit[n]uril (n = 5, 7, and 8)
Jaheon Kim,In-Sun Jung,Soo Young Kim,Eunsung Lee,Jin-Koo Kang,Shigeru Sakamoto,and Kentaro Yamaguchi,Kimoon Kim +7 more
Journal ArticleDOI
Nanotechnology in Drug Delivery and Tissue Engineering: From Discovery to Applications
TL;DR: Two important aspects of nanomedicine, drug delivery and tissue engineering are discussed, highlighting the advances the authors have recently experienced, the challenges they are currently facing, and what they are likely to witness in the near future.
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