Designing spike protein (S-Protein) based multi-epitope peptide vaccine against SARS COVID-19 by immunoinformatics.
TLDR
The immune simulation was conducted and conformed that the vaccine constructs can induces both acquired and humoral immunity effectively against COVID-19 at very low concentration, but along with bioinformatics study the need to conduct experiment in laboratory to validate its safety and effectiveness.About:
This article is published in Heliyon.The article was published on 2020-11-01 and is currently open access. It has received 19 citations till now. The article focuses on the topics: Peptide vaccine & Vaccination.read more
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Journal ArticleDOI
Immune Response to SARS-CoV-2 Vaccines
Navya Bellamkonda,Upendra P. Lambe,Sonali Sawant,Shyam Sundar Nandi,Chiranjib Chakraborty,Deepak Kumar Shukla +5 more
TL;DR: This review has compiled the immune response to SARS-CoV-2 infection and followed by the mechanism of action of various vaccine platforms such as mRNA vaccines, Adenoviral vectored vaccine, inactivated virus vaccines and subunit vaccines in the market.
Journal ArticleDOI
SARS-CoV-2 subunit vaccine adjuvants and their signaling pathways.
Daniel Mekonnen,Hylemariam Mihiretie Mengist,Hylemariam Mihiretie Mengist,Tengchuan Jin,Tengchuan Jin +4 more
TL;DR: In this paper, a review discusses about COVID-19 subunit vaccines adjuvants and their signaling pathways, which could provide a new strategy against the COVID19 pandemic.
Journal ArticleDOI
A novel vaccine based on SARS-CoV-2 CD4+ and CD8+ T cell conserved epitopes from variants Alpha to Omicron
Iam Palatnik-de-Sousa,Zachary S. Wallace,Stephany Christiny Cavalcante,Maria Paula Fonseca Ribeiro,João Antônio Barbosa Martins Silva,Rafael Ciro Cavalcante,Richard H. Scheuermann,Clarisa B. Palatnik-de-Sousa +7 more
TL;DR: In this paper , a multiepitope multivariant vaccine was designed using immunoinformatics and in silico approaches, which is composed of highly promiscuous and strong HLA binding CD4+ and CD8+ T cell epitopes of the S, M, N, E, ORF1ab, ORFs 6 and ORF8 proteins.
Journal ArticleDOI
Developing an Effective Peptide-Based Vaccine for COVID-19: Preliminary Studies in Mice Models
Haiqiang Yang,Xiaoyan Qin,Jingwen Yue,Tarek Zieneldien,Janice Kim,Lian-Ying Wang,Jianmin Fang,Ruo-Pan Huang,Yun Bai,Kevin B. Sneed,Chuanhai Cao +10 more
TL;DR: It is believed that the peptide-based vaccine can be a safe and effective vaccine against COVID-19, particularly because of the flexibility of including new peptides to prevent emerging SARS-CoV-2 variants and avoiding unwanted autoimmune responses.
Posted ContentDOI
Immunoinformatics approach for a novel multi-epitope vaccine construct against spike protein of human coronaviruses
TL;DR: In this article, a broad-spectrum multi-epitope vaccine candidate against S protein of human coronavirus was proposed and evaluated for antigenicity, allergenicity, solubility, and its ability to achieve high-level expression in bacterial hosts.
References
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Protein identification and analysis tools in the ExPASy server
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