Open AccessJournal Article
Dimercaptosuccinic Acid (DMSA), A Non-Toxic, Water-Soluble Treatment For Heavy Metal Toxicity
TLDR
DMSA is a sulfhydryl-containing, water-soluble, non-toxic, orally-administered metal chelator which has been in use as an antidote to heavy metal toxicity since the 1950s and is established as the premier metal chelation compound, based on oral dosing, urinary excretion, and its safety characteristics compared to other chelating substances.Abstract:
Heavy metals are, unfortunately, present in the air, water, and food supply. Cases of severe acute lead, mercury, arsenic, and cadmium poisoning are rare; however, when they do occur an effective, non-toxic treatment is essential. In addition, chronic, low-level exposure to lead in the soil and in residues of lead-based paint; to mercury in the atmosphere, in dental amalgams and in seafood; and to cadmium and arsenic in the environment and in cigarette smoke is much more common than acute exposure. Meso-2,3-dimercaptosuccinic acid (DMSA) is a sulfhydryl-containing, water-soluble, non-toxic, orally-administered metal chelator which has been in use as an antidote to heavy metal toxicity since the 1950s. More recent clinical use and research substantiates this compound’s efficacy and safety, and establishes it as the premier metal chelation compound, based on oral dosing, urinary excretion, and its safety characteristics compared to other chelating substances. (Altern Med Rev 1998;3(3):199-207)read more
Citations
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Therapeutic potentials of combined use of DMSA with calcium and ascorbic acid in the treatment of mild to moderately lead intoxicated mice
TL;DR: DMSA supplemented alone could reduce lead levels in both soft tissues and bone and reverse lead-inhibited activities of blood ALAD in mild to moderately lead-intoxicated mice, while combined use of DMSA with calcium and ascorbic acid achieved better therapeutic efficacies.
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The bioaccumulation of arsenic and the efficacy of meso-2, 3-dimercaptosuccinic acid in the selected organ tissues of Labeo rohita fingerlings using inductively coupled plasma-optical emission spectrometry.
TL;DR: It is suggested that DMSA is an effective chelator for arsenic in reducing the body burden of L. rohita fingerlings and could be suitable for monitoring the bioavailability of water-bound metals in freshwater habitats.
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Case report: heavy metal burden presenting as Bartter syndrome.
TL;DR: Treatment with body-weight doses of meso-2,3-dimercaptosuccinic acid (DMSA) reduced the body burden of lead, beryllium, copper, mercury, and cadmium at the three- and sixth-month follow-up tests.
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Thiol-Functionalized Mesoporous Silica for Effective Trap of Mercury in Rats
TL;DR: In this article, a series of thiol-functionalized mesoporous silica as oral formulation for the prevention and treatment of heavy metal poisoning was used for the FTIR spectra.
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Carboxyl and thiol-functionalized magnetic nanoadsorbents for efficient and simultaneous removal of Pb(II), Cd(II), and Ni(II) heavy metal ions from aqueous solutions: Studies of adsorption, kinetics, and isotherms
V.P. Kothavale,A. Sharma,Rushikesh P. Dhavale,V. D. Chavan,S. R. Shingte,Oleksandr Selyshchev,Tukaram D. Dongale,H.-H. Park,Dietrich R. T. Zahn,Georgeta Salvan,P.B. Patil +10 more
TL;DR: In this paper , a meso-2,3-dimercaptosuccinic acid (DMSA)-based nanoadsorbent was used for the simultaneous removal of Pb(II, Ni(II), and Cd(II).
References
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Dmsa and dmps-water soluble antidotes for heavy metal poisoning
TL;DR: This article reviews the pharmacological properties and the uses of two important antidotes for heavy metal poisoning, DMSA and DMPS, water soluble chemical analogs of dimercaprol, which have less toxicity, greater water solubility, and lim ited lipid solubilities, and are effective when given orally.
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Mercury exposure from "silver" tooth fillings: emerging evidence questions a traditional dental paradigm.
TL;DR: Animal and human experiments demonstrate that the uptake, tissue distribution, and excretion of amalgam Hg is significant, and that dental amalgam is the major contributing source to Hg body burden in humans.
Journal ArticleDOI
In vivo indices of oxidative stress in lead-exposed C57BL/6 mice are reduced by treatment with meso-2,3-Dimercaptosuccinic Acid or N-acetylcysteine
Nuran Ercal,Piyanee Treeratphan,Terese C. Hammond,Richard H. Matthews,Neil H. Grannemann,Douglas R. Spitz +5 more
TL;DR: Results suggest that lead-induced oxidative stress in vivo can be mitigated by pharmacologic interventions, which encompass both chelating as well as thiol-mediated antioxidant functions.
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