Distinct Age-Related Epigenetic Signatures in CD4 and CD8 T Cells.
Bin Hu,Bin Hu,Rohit R. Jadhav,Rohit R. Jadhav,Claire E. Gustafson,Claire E. Gustafson,Sabine Le Saux,Sabine Le Saux,Zhongde Ye,Zhongde Ye,Xuanying Li,Xuanying Li,Lu Tian,Cornelia M. Weyand,Cornelia M. Weyand,Jörg J. Goronzy,Jörg J. Goronzy +16 more
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TLDR
It is suggested that chromatin accessibility signatures can be identified that distinguish CD4 and CD8 T cells from old adults and that may confer the higher resilience of CD4 T cells to aging.Citations
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Metabolic programs tailor T cell immunity in viral infection, cancer, and aging.
TL;DR: In this paper , the metabolic-epigenetic axis orchestrates T cell exhaustion and explores how physiological factors, such as diet, gut microbiota, and the circadian clock, are integrated in shaping T cell epigenetic modifications and functionality.
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miR-181a-regulated pathways in T-cell differentiation and aging.
Chulwoo Kim,Zhongde Ye,Cornelia M. Weyand,Cornelia M. Weyand,Jörg J. Goronzy,Jörg J. Goronzy +5 more
TL;DR: The role of miR-181a in T cell development, T cell activation and antiviral T cell responses has been investigated in this paper, where the authors provide a framework for understanding how a decline in miR181a expression in T cells could contribute to age-related defects in adaptive immunity.
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Age as a risk factor in vasculitis
TL;DR: In this article , the authors review the evidence of how the process of immunosenescence impacts the risk for GCA and how fundamental differences in the age of the immune system translate into differences in granulomatous immunopathology of TAK versus GCA.
Journal ArticleDOI
Immunosenescence and Altered Vaccine Efficiency in Older Subjects: A Myth Difficult to Change
Tamas Fulop,Anis Larbi,Graham Pawelec,Alan A. Cohen,Guillaume Provost,Abedelouahed Khalil,Guy Lacombe,Serafim Rodrigues,Mathieu Desroches,Katsuiku Hirokawa,Claudio Franceschi,Jacek M. Witkowski +11 more
TL;DR: The most often cited vaccine failure is seasonal influenza, but, while it is usually the case that the efficiency of this vaccine is lower in older than younger adults, this is not always true, and the reasons for the differential responses are manifold as discussed by the authors .
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An immunologist’s guide to immunosenescence and its treatment
TL;DR: In this article , the authors focused on the biological and clinical meaning of immunosenescence and discussed the role of changes in lifestyle as a potential therapeutic approach, and pointed out that age is only part of the problem.
References
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The Hallmarks of Aging
TL;DR: Nine tentative hallmarks that represent common denominators of aging in different organisms are enumerated, with special emphasis on mammalian aging, to identify pharmaceutical targets to improve human health during aging, with minimal side effects.
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Transposition of native chromatin for fast and sensitive epigenomic profiling of open chromatin, DNA-binding proteins and nucleosome position
TL;DR: The feasibility of analyzing an individual's epigenome on a timescale compatible with clinical decision-making is demonstrated and classes of DNA-binding factors that strictly avoided, could tolerate or tended to overlap with nucleosomes are discovered.
Journal ArticleDOI
GREAT improves functional interpretation of cis-regulatory regions
Cory Y. McLean,Dave Bristor,Michael Hiller,Shoa L. Clarke,Bruce T. Schaar,Craig B. Lowe,Aaron M. Wenger,Gill Bejerano +7 more
TL;DR: The Genomic Regions Enrichment of Annotations Tool (GREAT) is developed to analyze the functional significance of cis-regulatory regions identified by localized measurements of DNA binding events across an entire genome.
Journal ArticleDOI
Differentiation of Effector CD4 T Cell Populations
TL;DR: This review summarizes the discovery, functions, and relationships among Th cells; the cytokine and signaling requirements for their development; the networks of transcription factors involved in their differentiation; the epigenetic regulation of their key cytokines and transcription factors; and human diseases involving defective CD4 T cell differentiation.
Journal ArticleDOI
The R package Rsubread is easier, faster, cheaper and better for alignment and quantification of RNA sequencing reads.
TL;DR: Rsubread is presented, a Bioconductor software package that provides high-performance alignment and read counting functions for RNA-seq reads that integrates read mapping and quantification in a single package and has no software dependencies other than R itself.
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