Journal ArticleDOI
Drug transport via the intestinal peptide transporter PepT1.
TLDR
The focus of this review is on the pharmaceutical relevance of the intestinal peptide transporter PepT1 and the progress made in the field over the past two years.About:
This article is published in Current Opinion in Pharmacology.The article was published on 2013-12-01. It has received 92 citations till now. The article focuses on the topics: Drug delivery.read more
Citations
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Journal ArticleDOI
The expanding role of prodrugs in contemporary drug design and development
TL;DR: This Review highlights prodrug design strategies for improved formulation and pharmacokinetic and targeting properties, with a focus on the most recently marketed prodrugs.
Journal ArticleDOI
Orally Absorbed Cyclic Peptides
Daniel S. Nielsen,Nicholas E. Shepherd,Weijun Xu,Andrew J. Lucke,Martin J. Stoermer,David P. Fairlie +5 more
TL;DR: The cyclic peptides violated to different degrees all of the limits traditionally considered to be important for oral bioavailability of drug-like small molecules, although fewer hydrogen bond donors and reduced flexibility generally favored oral absorption.
Journal ArticleDOI
Protein Abundance of Clinically Relevant Multidrug Transporters along the Entire Length of the Human Intestine
Marek Drozdzik,Christian Gröer,Jette Penski,Joanna Lapczuk,Marek Ostrowski,Yurong Lai,Bhagwat Prasad,Jashvant D. Unadkat,Werner Siegmund,Stefan Oswald +9 more
TL;DR: Analysis of intestinal transporters in healthy epithelium of the duodenum, the proximal and distal jejunum and ileum, and the ascending, transversal, descending, and sigmoidal colon of six organ donors provides further physiological pieces of the puzzle required to predict intestinal drug absorption in humans.
Journal ArticleDOI
The mechanisms of pharmacokinetic food-drug interactions - A perspective from the UNGAP group.
Mirko Koziolek,Stefano Alcaro,Patrick Augustijns,Abdul Basit,Michael Grimm,Bart Hens,Caroline L. Hoad,Philipp Jedamzik,Christine M. Madla,Marc Maliepaard,Luca Marciani,Annalisa Maruca,Neil Parrott,Petr Pavek,Christopher J.H. Porter,Christos Reppas,Diana van Riet-Nales,Jari Rubbens,Marina Statelova,Natalie L. Trevaskis,Kateřina Valentová,Maria Vertzoni,Dubravka Vitali Čepo,Maura Corsetti,Maura Corsetti +24 more
TL;DR: In this review of the UNGAP Working group "Food-Drug Interface", the different mechanisms that can lead to pharmacokinetic food-drug interactions are discussed and summarised from different expert perspectives.
Journal ArticleDOI
THE CONCISE GUIDE TO PHARMACOLOGY 2019/20: Transporters
Stephen P.H. Alexander,Eamonn Kelly,Alistair Mathie,John A. Peters,Emma L. Veale,Jane F. Armstrong,Elena Faccenda,Simon D. Harding,Adam J. Pawson,Joanna L. Sharman,Christopher Southan,Jamie A. Davies +11 more
TL;DR: The Concise Guide to PHARMACOLOGY 2019/20 provides concise overviews of the key properties of nearly 1800 human drug targets with an emphasis on selective pharmacology (where available), plus links to the open access knowledgebase source of drug targets and their ligands ( www.guidetopharmacology.org).
References
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Journal ArticleDOI
Differential Recognition of β-Lactam Antibiotics by Intestinal and Renal Peptide Transporters, PEPT 1 and PEPT 2
Malliga E. Ganapathy,Matthias Brandsch,Puttur D. Prasad,Vadivel Ganapathy,Frederick H. Leibach +4 more
TL;DR: It is concluded that there are marked differences between the intestinal and renal peptide transporters in the recognition of β-lactam antibiotics as substrates.
Journal ArticleDOI
Delta-aminolevulinic acid transport by intestinal and renal peptide transporters and its physiological and clinical implications.
Frank Döring,J. Walter,J Will,Melanie Föcking,Michael Boll,Salah Amasheh,Wolfgang Clauss,Hannelore Daniel +7 more
TL;DR: It is demonstrated that ALA uses the intestinal and renal apical peptide transporters for entering into epithelial cells and is electrogenic in nature as a consequence of H+/ALA cotransport.
Journal ArticleDOI
Crystal structure of a prokaryotic homologue of the mammalian oligopeptide–proton symporters, PepT1 and PepT2
Simon Newstead,David A. Drew,Alexander D. Cameron,Vincent L. G. Postis,Xiaobing Xia,Philip W. Fowler,Jean C. Ingram,Elisabeth P. Carpenter,Mark S.P. Sansom,Michael J. McPherson,Stephen A. Baldwin,So Iwata +11 more
TL;DR: The crystal structure of PepTSo is presented, a functionally similar prokaryotic homologue of the mammalian peptide transporters from Shewanella oneidensis, which reveals a ligand‐bound occluded state for the MFS and provides new insights into a general transport mechanism.
Journal ArticleDOI
Proton-coupled oligopeptide transporter family SLC15: physiological, pharmacological and pathological implications.
TL;DR: In this review, updated information is provided on the structure-function of PepT1, PepT2, PhT1 and PhT2 and their expression and localization in key tissues, and as potential targets for drug delivery.
Journal ArticleDOI
Pharmaceutical and pharmacological importance of peptide transporters.
TL;DR: The aim of this review is to put the reports on peptide transporter‐mediated drug uptake into perspective and to review the current knowledge on pharmacogenomics and clinical relevance of human peptide transporters.
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