Dual Requirement of CHD8 for Chromatin Landscape Establishment and Histone Methyltransferase Recruitment to Promote CNS Myelination and Repair.
Chuntao Zhao,Chuntao Zhao,Chen Dong,Chen Dong,Magali Frah,Yaqi Deng,Corentine Marie,Feng Zhang,Feng Zhang,Lingli Xu,Lingli Xu,Zhixing Ma,Xinran Dong,Yifeng Lin,Scott Koenig,Brahim Nait-Oumesmar,Donna M. Martin,Laiman N. Wu,Mei Xin,Wenhao Zhou,Carlos Parras,Q. Richard Lu,Q. Richard Lu +22 more
Reads0
Chats0
TLDR
The data indicate that CHD8 exhibits a dual function through inducing a cascade of chromatin reprogramming and recruiting H3K4 histone methyltransferases to establish oligodendrocyte identity, suggesting potential strategies of therapeutic intervention forCHD8-associated white matter defects.About:
This article is published in Developmental Cell.The article was published on 2018-06-18 and is currently open access. It has received 90 citations till now. The article focuses on the topics: Oligodendrocyte differentiation & Chromatin remodeling.read more
Citations
More filters
Journal ArticleDOI
In vivo Perturb-Seq reveals neuronal and glial abnormalities associated with autism risk genes.
Xin Jin,Sean Simmons,Amy X. Guo,Ashwin S. Shetty,Ashwin S. Shetty,Michelle Ko,Lan Nguyen,Vahbiz Jokhi,Elise B. Robinson,Elise B. Robinson,Paul Oyler,Nathan C. Curry,Giulio Deangeli,Simona Lodato,Joshua Z. Levin,Aviv Regev,Feng Zhang,Feng Zhang,Feng Zhang,Paola Arlotta,Paola Arlotta +20 more
TL;DR: In vivo Perturb-Seq can serve as a scalable tool for systems genetic studies of large gene panels to reveal their cell-intrinsic functions at single-cell resolution in complex tissues and allow simultaneous assessment of the individual phenotypes of a panel of such risk genes in the context of the developing mouse brain.
Journal ArticleDOI
Molecular Control of Oligodendrocyte Development
Benayahu Elbaz,Brian Popko +1 more
TL;DR: The characterization of several recently identified regulatory factors that govern these processes have greatly increased understanding of oligodendrocyte development and function and are critical to facilitate efforts to enhance OPC differentiation in neurological disorders that disrupt CNS myelin.
Journal ArticleDOI
A myelin-related transcriptomic profile is shared by Pitt-Hopkins syndrome models and human autism spectrum disorder.
BaDoi N. Phan,BaDoi N. Phan,Joseph F. Bohlen,Brittany A. Davis,Zeng You Ye,Huei Ying Chen,Brent Mayfield,Srinidhi Rao Sripathy,Stephanie Cerceo Page,Morganne N. Campbell,Hannah L. Smith,Danisha Gallop,Hyojin Kim,Courtney Thaxton,Jeremy M. Simon,Emily E. Burke,Joo Heon Shin,Joo Heon Shin,Andrew J. Kennedy,J. David Sweatt,Benjamin D. Philpot,Andrew E. Jaffe,Brady J. Maher,Brady J. Maher +23 more
TL;DR: An impaired myelination signature from the brains of mouse models of Pitt–Hopkins syndrome is identified and shared in the postmortem brains of people with autism, implicating disruptions in OL biology as a cellular mechanism in ASD pathology.
Journal ArticleDOI
Oligodendrocyte precursor survival and differentiation requires chromatin remodeling by Chd7 and Chd8.
Corentine Marie,Adrien Clavairoly,Magali Frah,Hatem Hmidan,Jun Yan,Chuntao Zhao,Juliette Van Steenwinckel,Romain Daveau,Bernard Zalc,Bassem A. Hassan,Jean-Leon Thomas,Jean-Leon Thomas,Pierre Gressens,Philippe Ravassard,Ivan Moszer,Donna M. Martin,Q. Richard Lu,Carlos Parras +17 more
TL;DR: It is shown that Chd 7 protects OPCs from apoptosis by chromatin closing and gene repression of p53, while Chd7 induces chromatin opening and gene activation of OPC-differentiation regulators, which offer new avenues to understand and modulate the CHD7 and CHD8 functions in normal development and disease.
Journal ArticleDOI
Autism-associated CHD8 deficiency impairs axon development and migration of cortical neurons
Qiong Xu,Qiong Xu,Yuan-yuan Liu,Xiaoming Wang,Guo-He Tan,Huiping Li,Samuel W Hulbert,Chun-yang Li,Chunchun Hu,Zhi-Qi Xiong,Xiu Xu,Yong-hui Jiang +11 more
TL;DR: Findings indicate an important role for CHD8 in dendritic and axon development and neuronal migration and thus offer novel insights to further dissect the underlying molecular and circuit mechanisms of ASD caused by CHd8 deficiency.
References
More filters
Journal ArticleDOI
The language of covalent histone modifications.
Brian D. Strahl,C D Allis +1 more
TL;DR: It is proposed that distinct histone modifications, on one or more tails, act sequentially or in combination to form a ‘histone code’ that is, read by other proteins to bring about distinct downstream events.
Journal ArticleDOI
Transposition of native chromatin for fast and sensitive epigenomic profiling of open chromatin, DNA-binding proteins and nucleosome position
TL;DR: The feasibility of analyzing an individual's epigenome on a timescale compatible with clinical decision-making is demonstrated and classes of DNA-binding factors that strictly avoided, could tolerate or tended to overlap with nucleosomes are discovered.
Journal ArticleDOI
Axonal transection in the lesions of multiple sclerosis.
TL;DR: Transected axons are common in the lesions of multiple sclerosis, and axonal transection may be the pathologic correlate of the irreversible neurologic impairment in this disease.
Journal ArticleDOI
ATAC-seq: A Method for Assaying Chromatin Accessibility Genome-Wide
TL;DR: This method probes DNA accessibility with hyperactive Tn5 transposase, which inserts sequencing adapters into accessible regions of chromatin, which can be used to infer regions of increased accessibility, as well as to map regions of transcription‐factor binding and nucleosome position.
Journal ArticleDOI
Active genes are tri-methylated at K4 of histone H3
Helena Santos-Rosa,Robert Schneider,Andrew J. Bannister,Julia A. Sherriff,Bradley E. Bernstein,N. C. Tolga Emre,Stuart L. Schreiber,Jane Mellor,Tony Kouzarides +8 more
TL;DR: It is shown that the Saccharomyces cerevisiae Set1 protein can catalyse di- and tri-methylation of K4 and stimulate the activity of many genes, establishing the concept of methyl status as a determinant for gene activity and extending considerably the complexity of histone modifications.
Related Papers (5)
Disruptive CHD8 Mutations Define a Subtype of Autism Early in Development
Raphael Bernier,Christelle Golzio,Bo Xiong,Holly A.F. Stessman,Bradley P. Coe,Osnat Penn,Kali Witherspoon,Jennifer Gerdts,Carl Baker,Anneke T. Vulto-van Silfhout,Janneke H M Schuurs-Hoeijmakers,Marco Fichera,Paolo Bosco,Serafino Buono,Antonino Alberti,Pinella Failla,Hilde Peeters,Jean Steyaert,Jean Steyaert,Lisenka E.L.M. Vissers,Ludmila Francescatto,Heather C Mefford,Jill A. Rosenfeld,Trygve E. Bakken,Brian J. O'Roak,Matthew R. Pawlus,Randall T. Moon,Randall T. Moon,Jay Shendure,David G. Amaral,Ed S. Lein,Julia Rankin,Corrado Romano,Bert B.A. de Vries,Nicholas Katsanis,Evan E. Eichler,Evan E. Eichler +36 more
Sporadic autism exomes reveal a highly interconnected protein network of de novo mutations
Brian J. O'Roak,Laura Vives,Santhosh Girirajan,Emre Karakoc,Niklas Krumm,Bradley P. Coe,Roie Levy,Arthur Ko,Choli Lee,Joshua D. Smith,Emily H. Turner,Ian B. Stanaway,Benjamin Vernot,Maika Malig,Carl Baker,Beau Reilly,Joshua M. Akey,Elhanan Borenstein,Elhanan Borenstein,Mark J. Rieder,Deborah A. Nickerson,Raphael Bernier,Jay Shendure,Evan E. Eichler,Evan E. Eichler +24 more
The autism-associated chromatin modifier CHD8 regulates other autism risk genes during human neurodevelopment
Justin Cotney,Rebecca A. Muhle,Stephen Sanders,Stephen Sanders,Li Liu,A. Jeremy Willsey,A. Jeremy Willsey,Wei Niu,Wenzhong Liu,Lambertus Klei,Jing Lei,Jun Yin,Steven K. Reilly,Andrew T.N. Tebbenkamp,Candace Bichsel,Mihovil Pletikos,Nenad Sestan,Kathryn Roeder,Matthew W. State,Bernie Devlin,James P. Noonan +20 more