Durability of viral suppression with first-line antiretroviral therapy in patients with HIV in the UK: an observational cohort study
Jemma L O'Connor,Colette Smith,Fiona C Lampe,Margaret Johnson,David R Chadwick,Mark T. Nelson,David Dunn,Alan Winston,Frank A Post,Caroline A. Sabin,Andrew N. Phillips,Jonathan Ainsworth,Sris Allan,Jane Anderson,Abdel Babiker,David Chadwick,Valerie Delpech,Martin Fisher,Brian Gazzard,Richard Gilson,Mark Gompels,Phillip Hay,Teresa Hill,Margaret Johnson,Sophie Jose,Stephen Kegg,Clifford Leen,Fabiola Martin,Chloe Orkin,Adrian Palfreeman,Andrew Phillips,Deenan Pillay,Frank A. Post,Jillian Pritchard,Memory Sachikonye,Achim Schwenk,Anjum Tariq,Roy Trevelion,John P. Walsh,A Glabay,N Perry,S Tilbury,Elaney Youssef,Duncan Churchill,Brian Gazzard,Mark Nelson,R Everett,David Asboe,S Mandalia,F Post,H Korat,Chris Taylor,Z Gleisner,Fowzia Ibrahim,L Campbell,RJ Gilson,N Brima,I Williams,M Johnson,M Youle,F Lampe,Colette J Smith,R Tsintas,C Chaloner,S Hutchinson,CA Sabin,AN Phillips,T Hill,S Jose,A Thornton,S Huntington,J Walsh,Nicola Mackie,Alan Winston,J Weber,F Ramzan,M Carder,C Orkin,J Lynch,J Hand,C de Souza,J Anderson,S Munshi,J Ainsworth,A Schwenk,Steve Miller,Christopher P. Wood,C Leen,A Wilson,Sheldon R. Morris,M Gompels,S Allan,Adrian Palfreeman,K Memon,A Lewszuk,D Chadwick,E Cope,J Gibson,S Kegg,P Main,S Mitchell,M Hunter,M Dhillon,F Martin,S Russell-Sharpe,A Harte,S Clay,A Tariq,H Spencer,Rachael M. Jones,J Pritchard,S Cumming,C Atkinson,V Delpech +113 more
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TLDR
For HIV-positive men who have sex with men, the estimates suggest that the probability of first viral rebound reaches a plateau of 1·4% per year after 45 years of age, and 1·0% when accounting for the fact that 29% of viral rebounds are temporary elevations.About:
This article is published in The Lancet HIV.The article was published on 2017-07-01 and is currently open access. It has received 48 citations till now. The article focuses on the topics: Viral load.read more
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Risk of HIV transmission through condomless sex in serodifferent gay couples with the HIV-positive partner taking suppressive antiretroviral therapy (PARTNER): final results of a multicentre, prospective, observational study
Alison Rodger,Valentina Cambiano,Tina Bruun,Pietro Vernazza,Simon Collins,Olaf Degen,Giulio Maria Corbelli,Vicente Estrada,Anna Maria Geretti,Apostolos Beloukas,Apostolos Beloukas,Dorthe Raben,Pep Coll,Andrea Antinori,Nneka Nwokolo,Armin Rieger,Jan M Prins,Anders Blaxhult,Rainer Weber,Arne Van Eeden,Norbert H. Brockmeyer,Amanda Clarke,Jorge del Romero Guerrero,François Raffi,Johannes R. Bogner,Gilles Wandeler,Jan Gerstoft,Félix Gutiérrez,Kees Brinkman,Maria Kitchen,Lars Østergaard,Agathe León,Matti Ristola,Heiko Jessen,Hans-Jürgen Stellbrink,Andrew N. Phillips,Jens D Lundgren,Patricia Cobarsi,Aroa Nieto,Michael Meulbroek,Antonia Carrillo,Jorge Saz,Jorge D.R. Guerrero,Mar Vera García,Mar Masiá,Catalina Robledano,Lorna Leal,Eva G. Redondo,Vicente Estrada,Rocio Marquez,Raquel Sandoval,Pompeyo Viciana,Nuria Espinosa,Luis F. López-Cortés,Daniel Podzamczer,Juan Tiraboschi,Sandra Morenilla,Antonio Antela,Elena Losada,Janey Sewell,Sarah Kirk,Alyson Knott,Thomas Fernandez,Mark Gompels,Louise Jennings,Lana Ward,Julie Fox,Julianne Lwanga,Ming Lee,Richard Gilson,Clifford Leen,Sheila Morris,Dan Clutterbuck,Michael Brady,David Asboe,Serge Fedele,Sarah Fidler,Norbert Brockmeyer,Anja Potthoff,Adriane Skaletz-Rorowski,Johannes Bogner,Ulrich Seybold,Julia Roider,Arne Jessen,Slobodan Ruzicic,Tim Kümmerle,Clara Lehmann,Sindy Bartel,Anja Hüfner,Jürgen K. Rockstroh,Karina Mohrmann,Christoph Boesecke,Ivanka Krznaric,Patrick Ingiliz,Christina Grube,Dominique Braun,Huldrych F. Günthard,Hansjakob Furrer,Andri Rauch,Patrick Schmid,Manuela Rasi,Denise Borso,Markus Stratmann,Oliver Caviezel,Marcel Stoeckle,Manuel Battegay,Philip E. Tarr,Vanessa Christinet,Florent Jouinot,Camille Isambert,Enos Bernasconi,Beatrice Bernasconi,Lene P. Jensen,Anne A. Bayer,Yordanos Yehdego,Ann Bach,Pia Handberg,Gitte Kronborg,Svend s. Pedersen,Nete Bülow,Bente Ramskover,Outi Debnam,Jussi Sutinen,Ronnie Ask,Bernt Hildingsson-Lundh,Katarina Westling,Eeva-Maija Frisen,Gráinne Cortney,Siobhan O'Dea,Stéphane De Wit,Coca Necsoi,Linos Vandekerckhove,Jean-Christophe Goffard,Sophie Henrard,Jan M. Prins,Hans-Henrik Nobel,Annouschka Weijsenfeld,Loek Elsenburg,Danielle Vos,Imke Hoijenga,Elisabeth Gisolf,Petra Van Bentum,Dominique Verhagen,Eric Billaud,Michel Ohayon,Daniel Gosset,Alexandre Fior,Gilles Pialoux,Pelagie Thibaut,Julie Chas,Vincent Leclercq,Vincent Pechenot,Vincent Coquelin,Christian Pradier,Sophie Breaud,Veronique Touzeau-Romer,Maria Kitchen Maria Geit,Mario Sarcletti,Martin Gisinger,Angela Oellinger,Samanta Menichetti,Teresa Bini,Cristina Mussini,Marianna Meschiari,Antonio Di Biagio,Lucia Taramasso,Benedetto Maurizio Celesia,M. Gussio,Nuno Janeiro +168 more
TL;DR: The results suggest that the risk of HIV transmission in gay couples through condomless sex when HIV viral load is suppressed is effectively zero, which supports the message of the U=U (undetectable equals untransmittable) campaign, and the benefits of early testing and treatment for HIV.
Journal ArticleDOI
HIV infection and COVID-19 death: a population-based cohort analysis of UK primary care data and linked national death registrations within the OpenSAFELY platform.
Krishnan Bhaskaran,Christopher T Rentsch,Brian MacKenna,Anna Schultze,Amir Mehrkar,Chris Bates,Rosalind M Eggo,Caroline E Morton,Sebastian Bacon,Peter Inglesby,Ian J. Douglas,Alex J Walker,Helen Mcdonald,Jonathan Cockburn,Elizabeth A. Williamson,David M. Evans,Harriet Forbes,Helen J Curtis,William J Hulme,John Parry,Frank Hester,Sam Harper,Stephen J. W. Evans,Stephen J. W. Evans,Liam Smeeth,Ben Goldacre +25 more
TL;DR: People with HIV in the UK seem to be at increased risk of COVID-19 mortality, and targeted policies should be considered to address this raised risk as the pandemic response evolves.
Posted ContentDOI
HIV infection and COVID-19 death: population-based cohort analysis of UK primary care data and linked national death registrations within the OpenSAFELY platform
Krishnan Bhaskaran,Christopher T Rentsch,Brian MacKenna,Anna Schultz,Amir Mehrkar,Chris Bates,Rosalind M Eggo,Caroline E Morton,Seb Bacon,Peter Inglesby,Ian J. Douglas,Alex J Walker,Helen Mcdonald,Jonathan Cockburn,Elizabeth A. Williamson,David M. Evans,Harriet Forbes,Helen J Curtis,William J Hulme,John Parry,Frank Hester,Sam Harper,Stephen J. W. Evans,Liam Smeeth,Ben Goldacre +24 more
TL;DR: HIV infection was associated with a markedly raised risk of COVID-19 death in a country with high levels of antiretroviral therapy coverage and viral suppression; the association was larger in people of black ethnicity.
Journal ArticleDOI
HIV virologic failure and its predictors among HIV-infected adults on antiretroviral therapy in the African Cohort Study.
Francis Kiweewa,Allahna Esber,Allahna Esber,Ezra Musingye,Domonique Reed,Domonique Reed,Trevor A Crowell,Trevor A Crowell,Fatim Cham,Michael Semwogerere,Rosemary Namagembe,Alice Nambuya,Cate Kafeero,Allan Tindikahwa,Leigh Anne Eller,Leigh Anne Eller,Monica Millard,Huub C. Gelderblom,Babajide Keshinro,Yakubu Adamu,Jonah Maswai,John Owuoth,Valentine Singoei,Lucas Maganga,Emmanuel Bahemana,Samoel Khamadi,Merlin L. Robb,Merlin L. Robb,Julie A Ake,Christina S Polyak,Christina S Polyak,Hannah Kibuuka +31 more
TL;DR: It is shown that HIV-infected patients established on ART for more than six months in the African setting frequently experienced viraemia while continuing to be on ART, and being on second line, low CD4 count, missing any day of ART and history of fever in the past week remain important predictors of virology failure.
References
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Declining morbidity and mortality among patients with advanced human immunodeficiency virus infection. HIV Outpatient Study Investigators.
Frank J. Palella,Kathleen M. Delaney,Anne C. Moorman,Mark O. Loveless,Jack Fuhrer,Glen A. Satten,Diane J. Aschman,Scott D. Holmberg +7 more
TL;DR: The recent declines in morbidity and mortality due to AIDS are attributable to the use of more intensive antiretroviral therapies.
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Prevention of HIV-1 Infection with Early Antiretroviral Therapy
Myron S. Cohen,Ying Q. Chen,Marybeth McCauley,Theresa Gamble,Mina C. Hosseinipour,Nagalingeswaran Kumarasamy,James Hakim,Johnstone Kumwenda,Beatriz Grinsztejn,José Henrique Pilotto,Sheela Godbole,Sanjay Mehendale,Suwat Chariyalertsak,Breno Santos,Kenneth H. Mayer,Irving F. Hoffman,Susan H. Eshleman,Estelle Piwowar-Manning,Lei Wang,Joseph Makhema,Lisa A. Mills,Guy de Bruyn,Ian Sanne,Joseph J. Eron,Joel E. Gallant,Diane V. Havlir,Susan Swindells,Heather J. Ribaudo,Vanessa Elharrar,David N. Burns,Taha E. Taha,Karin Nielsen-Saines,David D. Celentano,Myron Essex,Thomas R. Fleming +34 more
TL;DR: In this article, Antiretroviral therapy that reduces viral replication could limit the transmission of human immunodeficiency virus type 1 (HIV-1) in serodiscordant couples.
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Declining Morbidity and Mortality among Patients with Advanced Human Immunodeficiency Virus Infection
TL;DR: A study was conducted to evaluate the impact of protease inhibitors on the rates of selected opportunistic processes and mortality in patients with AIDS and found similar results.
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Guidelines for the use of antiretroviral agents in HIV-infected adults and adolescents
Anthony S. Fauci,John G. Bartlett,Eric P. Goosby,M. D. Smith,H. J. Kaiser,S. W. Chang,James M. Anderson,R. Armstead,A. C. Baker,David A Barr,Samuel A. Bozzette,S. Cox,M. Delaney,Fred M. Gordin,W. Greaves,M. Harrington,J. J. Henning,Martin S. Hirsch,J. Jacobs,Richard Marlink,C. Maxwell,J. W. Mellors,D. B. Nash,S. Perryman,Robert T. Schooley,R. Sherer,Stephen A. Spector,G. Torres,Paul A. Volberding,B. A. Brady,E. M. Daniels,D. Feigal,Mark B. Feinberg,H. D. Gayle,T. R. Graydon,Jonathan E. Kaplan,Abe M. Macher,R. F. Martin,Henry Masur,Lynne M. Mofenson,J. Murray,J. O'Neill,L. C. Perez,R. Riseberg,S. Shekar,Sharilyn K. Stanley,J. Whitescarver +46 more
TL;DR: These Guidelines were developed by the Panel* on Clinical Practices for Treatment of HIV Infection convened by the Department of Health and Human Services and the Henry J. Kaiser Family Foundation.
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Prevention of HIV-1 infection with early antiretroviral therapy
TL;DR: The exciting evidence generated by this paper – that antiretroviral treatment of HIV-1 infection definitively reduces the risk of onward transmission of the virus by 96% – was rightly dubbed Science magazine's ‘Breakthrough of the Year’ in 2011.
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Sexual Activity Without Condoms and Risk of HIV Transmission in Serodifferent Couples When the HIV-Positive Partner Is Using Suppressive Antiretroviral Therapy
Alison Rodger,Valentina Cambiano,Tina Bruun,Pietro Vernazza,Simon Collins,Jan van Lunzen,Giulio Maria Corbelli,Vicente Estrada,Anna Maria Geretti,Apostolos Beloukas,David Asboe,Pompeyo Viciana,Félix Gutiérrez,Bonaventura Clotet,Christian Pradier,Jan Gerstoft,Rainer Weber,Katarina Westling,Gilles Wandeler,Jan M. Prins,Armin Rieger,Marcel Stoeckle,Tim Kümmerle,Teresa Bini,Adriana Ammassari,Richard Gilson,Ivanka Krznaric,Matti Ristola,Robert Zangerle,Pia Handberg,Antonio Antela,Sris Allan,Andrew N. Phillips,Jens D Lundgren +33 more
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