Effects of a Chinese Herbal Medicine, Guan-Jen-Huang (Aeginetia indica Linn.), on Renal Cancer Cell Growth and Metastasis.
Yu-Huei Liu,Meng-Luen Li,Meng-Yu Hsu,Ya-Yueh Pang,I-Ling Chen,Ching-Kuei Chen,Sai-Wen Tang,Hsuan-Yuan Lin,Jung-Yaw Lin +8 more
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TLDR
GJH extract has a synergistic effect on apoptosis induced by chemotherapeutic agents and an inhibitory effect on cell adhesion, migration, and invasion, providing evidence for the use of water-based extracts of GJH as novel alternative therapeutic agents in the treatment of human renal cancer.Abstract:
Aeginetia indica Linn. (Guan-Jen-Huang, GJH), a traditional Chinese herb, has the potential to be an immunomodulatory agent. The purpose of this study was to explore the effect of GJH in the treatment of renal cancer. Concentration-effect curves for the influence of GJH on cellular proliferation showed a biphasic shape. Besides, GJH had a synergistic effect on cytotoxicity when combined with 5-fluorouracil (5-FU)which may be due to the alternation of the chemotherapeutic agent resistance-related genes and due to the synergistic effects on apoptosis. In addition, treatment with GJH extract markedly reduced 786-O cell adherence to human umbilical vein endothelial cells (HUVECs) and decreased 786-O cell migration and invasion. In a xenograft animal model, GJH extract had an inhibitory effect on tumor cell-induced metastasis. Moreover, western blot analysis showed that the expression of intercellular adhesion molecule-1 (ICAM-1) in 786-O cells was significantly decreased by treatment with GJH extract through inactivation of nuclear factor-κB (NF-κB). These results suggest that GJH extract has a synergistic effect on apoptosis induced by chemotherapeutic agents and an inhibitory effect on cell adhesion, migration, and invasion, providing evidence for the use of water-based extracts of GJH as novel alternative therapeutic agents in the treatment of human renal cancer.read more
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Pharmacological investigation of analgesic and antipyretic activities of methanol extract of the whole part of Aeginetia indica.
Sharif Reza,Jashimuddin,Jamiuddin Ahmed,Muhammad Abeer,Nura Ershad Naznin,Sarah Jafrin,Enamul Haque,Abdul Barek,A F M Shahid Ud Daula +8 more
TL;DR: In this article, the authors evaluated the analgesic and antipyretic potential of Aeginetia indica plant extract to verify its effectiveness as reported in traditional uses, which supported the claim of its folk uses.
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Recent insights into the hepatoprotective potential of medicinal plants and plant‐derived compounds
TL;DR: In this paper , the authors focused on newly discovered medicinal plants and compounds produced from plants that fall under the classifications of flavonoids, alkaloids, terpenoids, polyphenolics, sterols, anthocyanins, and saponin glycosides, all of which have the potential to be hepatoprotective.
Increasing evidences of the acupuncture and herbal medicine used as complementary therapies to treat cancers
Lynsey Smith,Caroline Nguyen,Caitlin Gallacher,Duke Torres,Azizat Agbetoba,Jamie Folk,Anu Sankaran,Sara Mueller,Jessica Messa,Trey Fisher,Brook Paterra,Kim Ann Pham,Ke-He Ruan +12 more
TL;DR: This mini-review will examine how acupuncture has been used to help alleviate side effects of cancer treatment and traditional herbs such as Huang Qi Liu Yi Tang, Scutellaria barbata, Dihydroartemisinin, Essiac, Guan-Jen-Huang, Yashtimadhu, and Laetrile and the role they play in cancer treatment.
Journal ArticleDOI
Aeginetia indica (forest ghost flower)
TL;DR: A datasheet on Aeginetia indica covers Identity, Overview, Distribution, Dispersal, Hosts/Species Affected, Diagnosis, Biology & Ecology, Environmental Requirements, Natural Enemies, Impacts, Uses, Prevention/Control, Further Information as mentioned in this paper .
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EAU Guidelines on Renal Cell Carcinoma: 2014 Update
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Michael Karin,Florian R. Greten +1 more
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