Effects of Striatal ΔFosB Overexpression and Ketamine on Social Defeat Stress–Induced Anhedonia in Mice
TLDR
This study found that CSDS triggers persistent anhedonia and confirms that ΔFosB overexpression produces stress resilience, and indicates that acute administration of ketamine fails to attenuate CSDS-inducedAnhedonia despite reducing other depression-related behavioral abnormalities.About:
This article is published in Biological Psychiatry.The article was published on 2014-10-01 and is currently open access. It has received 142 citations till now. The article focuses on the topics: Anhedonia & Social defeat.read more
Citations
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NMDAR inhibition-independent antidepressant actions of ketamine metabolites
Panos Zanos,Ruin Moaddel,Patrick J. Morris,Polymnia Georgiou,Jonathan Fischell,Greg I. Elmer,Manickavasagom Alkondon,Peixiong Yuan,Heather J. Pribut,Nagendra Singh,Katina Sourou Sylvestre Dossou,Yuhong Fang,Xi Ping Huang,Cheryl L. Mayo,Irving W. Wainer,Edson X. Albuquerque,Scott M. Thompson,Craig J. Thomas,Carlos A. Zarate,Todd D. Gould +19 more
TL;DR: It is shown that the metabolism of (R,S)-ketamine to (2S,6S;2R,6R)-hydroxynorketamine (HNK) is essential for its antidepressant effects, and that the HNK enantiomer exerts behavioural, electroencephalographic, electrophysiological and cellular antidepressant-related actions in mice.
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Targeting glutamate signalling in depression: progress and prospects
TL;DR: The glutamate N-methyl-D-aspartate receptor (NMDAR) antagonist ketamine was recently repurposed as a rapidly acting antidepressant, catalysing the vigorous investigation of glutamate-signalling modulators as novel therapeutic agents for depressive disorders.
Journal ArticleDOI
Stress, social behavior, and resilience: insights from rodents.
TL;DR: This review explores mechanistic and behavioral links between stress, anxiety, resilience, and social behavior in rodents, with particular attention to different social contexts.
Journal ArticleDOI
Dendritic Spines in Depression: What We Learned from Animal Models
TL;DR: Current understanding of the chronic stress-induced remodeling of dendritic spines in the hippocampus, prefrontal cortex, orbitofrontal cortex, amygdala, and nucleus accumbens is summarized and the putative underlying mechanisms are discussed.
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Immediate Early Genes, Memory and Psychiatric Disorders: Focus on c-Fos, Egr1 and Arc.
Francisco Tomás Gallo,Cynthia Katche,Juan Facundo Morici,Jorge H. Medina,Noelia V. Weisstaub +4 more
TL;DR: The role of some of the most relevant IEGs in relation with memory processes affected in psychiatric conditions, including c-fos, Egr1 and arc are discussed.
References
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Ronald C. Kessler,Patricia A. Berglund,Olga Demler,Robert Jin,Kathleen R. Merikangas,Ellen E. Walters +5 more
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