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Journal ArticleDOI

El café y sus efectos en la salud cardiovascular y en la salud materna

12 Jan 2010-Vol. 37, Iss: 4, pp 514-523

TL;DR: La conclusion general es that el consumo of cafeina, hasta 300 mg/dia, no constituye un mayor riesgo of infarto al miocardio, of hipertension, o of modificacion of los niveles plasmaticos de indicadores of riesgos cardiovascular, como the proteina C reactiva y the homocisteina.

AbstractLa cafeina es el principal componente activo del cafe y los efectos del consumo de cafe se asocian mayoritariamente a la cafeina, una metilxantina que actua como antagonista de los receptores de adenina en el sistema nervioso. Son numerosos los efectos en la salud atribuidos a la cafeina, siendo algunos beneficos y otros deletereos: en la salud cardiovascular, diabetes tipo 2, tolerancia a la glucosa y sensibilidad a la insulina, en la cinosis hepatica y el carcinoma hepatocelular, entre otros efectos. Este articulo realiza una revision de dos aspectos de preocupacion en la salud publica relacionados con el consumo de cafe y la cafeina: su efecto en la salud cardiovascular y en la salud maternal (periodo perinatal). La conclusion general es que el consumo de cafeina, hasta 300 mg/dia, no constituye un mayor riesgo de infarto al miocardio, de hipertension, o de modificacion de los niveles plasmaticos de indicadores de riesgo cardiovascular, como la proteina C reactiva y la homocisteina. En relacion a la salud maternal, las conclusiones son similares, un consumo moderado de cafeina (300 mg/dia o menos) no constituye un riesgo de menor concepcion, de diabetes gestacional, de menor crecimiento fetal, o de defectos congenitos. La ausencia de riesgo, sin embargo, no constituye un estimulo al consumo de cafe durante el embarazo. Si el consumo de cafe por parte de la futura madre es moderado, puede considerarse la continuacion del consumo durante el embarazo bajo supervision medica

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Journal ArticleDOI
TL;DR: This work provides a detailed overview of ACs occurrence in water bodies along with their toxicological effect on living organisms and robust detection and removal strategies must be considered in the design of WWTPs and DWTPs.
Abstract: Existence of anthropogenic contaminants (ACs) in different environmental matrices is a serious and unresolved concern. For instance, ACs from different sectors, such as industrial, agricultural, and pharmaceutical, are found in water bodies with considerable endocrine disruptors potency and can damage the biotic components of the environment. The continuous ACs exposure can cause cellular toxicity, apoptosis, genotoxicity, and alterations in sex ratios in human beings. Whereas, aquatic organisms show bioaccumulation, trophic chains, and biomagnification of ACs through different entry route. These problems have been found in many countries around the globe, making them a worldwide concern. ACs have been found in different environmental matrices, such as water reservoirs for human consumption, wastewater treatment plants (WWTPs), drinking water treatment plants (DWTPs), groundwaters, surface waters, rivers, and seas, which demonstrate their free movement within the environment in an uncontrolled manner. This work provides a detailed overview of ACs occurrence in water bodies along with their toxicological effect on living organisms. The literature data reported between 2017 and 2018 is compiled following inclusion-exclusion criteria, and the obtained information was mapped as per type and source of ACs. The most important ACs are pharmaceuticals (diclofenac, ibuprofen, naproxen, ofloxacin, acetaminophen, progesterone ranitidine, and testosterone), agricultural products or pesticides (atrazine, carbendazim, fipronil), narcotics and illegal drugs (amphetamines, cocaine, and benzoylecgonine), food industry derivatives (bisphenol A, and caffeine), and personal care products (triclosan, and other related surfactants). Considering this threatening issue, robust detection and removal strategies must be considered in the design of WWTPs and DWTPs.

92 citations


Journal ArticleDOI
TL;DR: Inclusion of up to 10% coffee pulp in the diet of ewe lambs for 16 days prior to breeding improves oxidative status without causing adverse effects on pregnancy, estrus or prolificacy.
Abstract: Background: Coffee pulp has a high content of antioxidants capable of modifying the oxidative status in small ruminants. However, high amounts for a prolonged time can reduce fertility. Objective: To determine the effect of two inclusion levels of coffee pulp during estrous synchronization on reproductive variables and oxidative status of primiparous ewes. Methods: Sixty Suffolk x Dorset primiparous ewes were distributed into three treatments in a completely randomized design; T0: (n=20) 1.5 kg balanced diet, Tl: (n=20) 1.5 kg balanced diet and 5% coffee pulp, T2: (n=20) 1.5 kg balanced diet and 10% coffee pulp. Supplementation was given for 16 days before estrus synchronization and until the beginning of the breeding season. A progestogen (CIDR®) was inserted for ll days and a dose of PGF2a was applied two days prior to its withdrawal. Estrus detection started 12 hours after CIDR withdrawal. Blood samples were obtained during the supplementation period to measure oxidative status, antioxidant capacity, glucose and insulin, and up to 9 days after breeding to determine progesterone concentration. Pregnancy diagnosis was performed at 30 and 60 days post-breeding. An analysis of repeated measures of mixed effects and frequency analysis were carried out. Results: Inclusion of coffee pulp for a short period prior to breeding did not affect reproductive parameters, nor progesterone, glucose or insulin concentrations (p>0.05); however, antioxidant capacity increased, while lipid oxidation showed an opposite trend (p<0.05). Conclusion: Inclusion of up to 10% coffee pulp in the diet of ewe lambs for 16 days prior to breeding improves oxidative status without causing adverse effects on pregnancy, estrus or prolificacy.

4 citations


Cites background from "El café y sus efectos en la salud c..."

  • ...Caffeine was previously reported as not reducing fertility in women (Wesselink et al., 2016); According to Valenzuela (2010), pregnant women consuming less than 300 mg of caffeine do not present risks....

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Journal ArticleDOI
Abstract: espanolEn el procesamiento del cafe, solo se aprovecha el 5 % del producto fresco y se generan residuos como aguas mieles (AM), que pueden llegar hasta 40 L/Kg de cafe pergamino seco y al ser vertidas pueden provocar contaminacion de alto impacto ambiental. Consecuentemente, el objetivo fue caracterizar fisicoquimica y microbiologicamente dos muestras de AM (M1, M2) con el fin de evaluar el potencial en la extraccion de biocomponentes. Los parametros medidos a las dos muestras de agua fueron Demanda Quimica de Oxigeno (DQO), nitrogeno, amonio, cromo, oxigeno disuelto (OD), pH, conductividad, acidez volatil, fosforo, cloruros, solidos, color y, adicionalmente se cuantificaron mesofilos, coliformes totales y estafilococos. Se identificaron diferencias significativas entre las muestras y un efecto del procesamiento del cafe, sobre las caracteristicas evaluadas. M2 mostro mayor concentracion de OD, conductividad y cambio de color respecto al control, mientras que M1 tuvo mayor concentracion para los demas parametros evaluados. Cromo y amonio estuvieron por debajo del limite de deteccion de la prueba empleada, por el contrario, la DQO fue superior a lo reglamentado para aguas domesticas. En el analisis microbiologico, se encontraron mesofilos en ambas muestras, y M2 presento coliformes y estafilococos. Con lo anterior se evidencia que el metodo de procesamiento de cafe afecta los parametros de calidad de las aguas residuales y por ende se deben implementar metodologias de tratamiento y/o aprovechamiento acordes a las caracteristicas intrinsecas de cada proceso. EnglishIn the coffee processing, only 5 % of the fresh product is used and waste is generated as wastewater (WW), which can reach up to 40 L / Kg of dry parchment coffee and when spilled can cause pollution of high environmental impact. Consequently, the objective was to characterize physicochemical and microbiologically two WW samples (M1, M2) in order to evaluate the potential in the extraction of biocomponents. The parameters measured to the two water samples were Chemical Oxygen Demand (COD), nitrogen, ammonium, chromium, dissolved oxygen (DO), pH, conductivity, volatile acidity, phosphorus, chlorides, solids, color and, in addition, mesophiles, total coliforms and staphylococci were also quantified. Significant differences between the samples and an effect of coffee processing on the characteristics evaluated were identified. M2 showed a higher concentration of OD, conductivity and color change with respect to the control, while M1 had a higher concentration for the other parameters. Chromium and ammonium were below the detection limit of the test used, on the contrary, the COD was higher than what was regulated for domestic waters. In the microbiological analysis, mesophiles were found in both samples, and M2 presented coliforms and staphylococci. With the above it is evident that the coffee processing method affects the parameters of wastewater quality and therefore treatment and/or exploitation methodologies must be implemented according to the intrinsic characteristics of each process. portuguesNo processamento de cafe, apenas 5 % do produto fresco e utilizado e os residuos sao gerados como aguas residuais (AR), que pode chegar a 40 L / Kg de cafe em pergaminho seco e quando derramado pode causar poluicao de alto impacto ambiental. Consequentemente, o objetivo foi caracterizar fisicoquimica e microbiologicamente duas amostras de AR (M1, M2), a fim de avaliar o potencial na extracao de biocomponentes. Os parâmetros medidos para as duas amostras de agua foram: Demanda Quimica de Oxigenio (DQO), nitrogenio, amonio, cromo, oxigenio dissolvido (DO), pH, condutividade, acidez volatil, fosforo, cloretos, solidos, cor e, alem disso, mesofilos, coliformes totais e estafilococos tambem foram quantificados. Diferencas significativas entre as amostras e um efeito do processamento do cafe nas caracteristicas avaliadas foram identificadas. M2 apresentou maior concentracao de OD, condutividade e mudanca de cor em relacao ao controle, enquanto M1 apresentou maior concentracao para os demais parâmetros. O cromo e o amonio estavam abaixo do limite de deteccao do teste utilizado; pelo contrario, o DQO foi superior ao regulamentado para as aguas domesticas. Na analise microbiologica, mesofilos foram encontrados em ambas as amostras, e M2 apresentou coliformes e estafilococos. Com o exposto, e evidente que o metodo de processamento do cafe afeta os parâmetros da qualidade das aguas residuais e, portanto, as metodologias de tratamento e / ou exploracao devem ser implementadas de acordo com as caracteristicas intrinsecas de cada processo.

3 citations


Cites background from "El café y sus efectos en la salud c..."

  • ...Aproximadamente el 30 % de la población mundial consume una vez al día una taza de café [1]....

    [...]


Journal ArticleDOI
15 Jul 2019
Abstract: 1 Doctor en Medicina, Master en Salud Publica. Docente del Departamento de Salud Publica, Facultad de Ciencias de la Salud “Dr. Luis Edmundo Vasquez”, Universidad Dr. Jose Matias Delgado. jamaravillaa@ujmd.edu.sv 2 Doctora en Medicina, Master en Gerontologia. Master en Investigacion. Vicedecana de la Facultad de Medicina, Universidad Evangelica de El Salvador. yomara.lucero@uees.edu.sv 3 Doctor en Medicina, Master en Salud Publica, Master en Docencia Universitaria. Hospital Militar. dr.cisneross@gmail.com 4 Doctor en Medicina, Master en Salud Publica. Decano de la Facultad de Medicina, Universidad Evangelica de El Salvador. douglas.barrera@uees.edu.sv

3 citations


Journal ArticleDOI
04 Sep 2020
TL;DR: The number of medical students dependent on tobacco increases as they advance in the clinical area, despite this, the percentage of UEES medicine students who smoke is almost half of the prevalence of smoking in young Latin Americans.
Abstract: Docente investigador, maestro en ciencias. Docente de Universidad Tecnologica de El Salvador. fabioverano120@gmail.com

3 citations


References
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TL;DR: The chronic hyperglycemia of diabetes is associated with long-term damage, dys-function, and failure of differentorgans, especially the eyes, kidneys, nerves, heart, and blood vessels.

12,946 citations


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TL;DR: Gestational diabetes mellitus (GDM) is defined as glucose intolerance of various degrees that is first detected during pregnancy and provides a unique opportunity to study the early pathogenesis of diabetes and to develop interventions to prevent the disease.
Abstract: Gestational diabetes mellitus (GDM) is defined as glucose intolerance of various degrees that is first detected during pregnancy. GDM is detected through the screening of pregnant women for clinical risk factors and, among at-risk women, testing for abnormal glucose tolerance that is usually, but not invariably, mild and asymptomatic. GDM appears to result from the same broad spectrum of physiological and genetic abnormalities that characterize diabetes outside of pregnancy. Indeed, women with GDM are at high risk for having or developing diabetes when they are not pregnant. Thus, GDM provides a unique opportunity to study the early pathogenesis of diabetes and to develop interventions to prevent the disease.

1,916 citations


Journal ArticleDOI
TL;DR: Differences in rates of progression between ethnic groups was reduced by adjustment for various lengths of follow-up and testing rates, so that women appeared to progress to type 2 diabetes at similar rates after a diagnosis of GDM.
Abstract: OBJECTIVE —To examine factors associated with variation in the risk for type 2 diabetes in women with prior gestational diabetes mellitus (GDM). RESEARCH DESIGN AND METHODS —We conducted a systematic literature review of articles published between January 1965 and August 2001, in which subjects underwent testing for GDM and then testing for type 2 diabetes after delivery. We abstracted diagnostic criteria for GDM and type 2 diabetes, cumulative incidence of type 2 diabetes, and factors that predicted incidence of type 2 diabetes. RESULTS —A total of 28 studies were examined. After the index pregnancy, the cumulative incidence of diabetes ranged from 2.6% to over 70% in studies that examined women 6 weeks postpartum to 28 years postpartum. Differences in rates of progression between ethnic groups was reduced by adjustment for various lengths of follow-up and testing rates, so that women appeared to progress to type 2 diabetes at similar rates after a diagnosis of GDM. Cumulative incidence of type 2 diabetes increased markedly in the first 5 years after delivery and appeared to plateau after 10 years. An elevated fasting glucose level during pregnancy was the risk factor most commonly associated with future risk of type 2 diabetes. CONCLUSIONS —Conversion of GDM to type 2 diabetes varies with the length of follow-up and cohort retention. Adjustment for these differences reveals rapid increases in the cumulative incidence occurring in the first 5 years after delivery for different racial groups. Targeting women with elevated fasting glucose levels during pregnancy may prove to have the greatest effect for the effort required.

1,890 citations


Journal ArticleDOI
22 May 1996-JAMA
TL;DR: Hypertension was the most common risk factor for CHF, and it contributed a large proportion of heart failure cases in this population-based sample, and Preventive strategies directed toward earlier and more aggressive blood pressure control are likely to offer the greatest promise for reducing the incidence of CHF and its associated mortality.
Abstract: Objective. —To study the relative and population-attributable risks of hypertension for the development of congestive heart failure (CHF), to assess the time course of progression from hypertension to CHF, and to identify risk factors that contribute to the development of overt heart failure in hypertensive subjects. Design. —Inception cohort study. Setting. —General community. Participants. —Original Framingham Heart Study and Framingham Offspring Study participants aged 40 to 89 years and free of CHF. To reflect more contemporary experience, the starting point of this study was January 1, 1970. Exposure Measures. —Hypertension (blood pressure of at least 140 mm Hg systolic or 90 mm Hg diastolic or current use of medications for treatment of high blood pressure) and other potential CHF risk factors were assessed at periodic clinic examinations. Outcome Measure. —The development of CHF. Results. —A total of 5143 eligible subjects contributed 72422 person-years of observation. During up to 20.1 years of follow-up (mean, 14.1 years), there were 392 new cases of heart failure; in 91% (357/392), hypertension antedated the development of heart failure. Adjusting for age and heart failure risk factors in proportional hazards regression models, the hazard for developing heart failure in hypertensive compared with normotensive subjects was about 2-fold in men and 3-fold in women. Multivariable analyses revealed that hypertension had a high population-attributable risk for CHF, accounting for 39% of cases in men and 59% in women. Among hypertensive subjects, myocardial infarction, diabetes, left ventricular hypertrophy, and valvular heart disease were predictive of increased risk for CHF in both sexes. Survival following the onset of hypertensive CHF was bleak; only 24% of men and 31% of women survived 5 years. Conclusions. —Hypertension was the most common risk factor for CHF, and it contributed a large proportion of heart failure cases in this population-based sample. Preventive strategies directed toward earlier and more aggressive blood pressure control are likely to offer the greatest promise for reducing the incidence of CHF and its associated mortality. (JAMA. 1996;275:1557-1562)

1,751 citations