Electronic control of DNA-based nanoswitches and nanodevices
Simona Ranallo,Alessia Amodio,Alessia Amodio,Andrea Idili,Alessandro Porchetta,Francesco Ricci +5 more
TLDR
Here it is demonstrated that one can rationally and finely control the functionality of different DNA-based nanodevices and nanoswitches using electronic inputs.Abstract:
Here we demonstrate that we can rationally and finely control the functionality of different DNA-based nanodevices and nanoswitches using electronic inputs. To demonstrate the versatility of our approach we have used here three different model DNA-based nanoswitches triggered by heavy metals and specific DNA sequences and a copper-responsive DNAzyme. To achieve electronic-induced control of these DNA-based nanodevices we have applied different voltage potentials at the surface of an electrode chip. The applied potential promotes an electron-transfer reaction that releases from the electrode surface a molecular input that ultimately triggers the DNA-based nanodevice. The use of electronic inputs as a way to finely activate DNA-based nanodevices appears particularly promising to expand the available toolbox in the field of DNA nanotechnology and to achieve a better hierarchical control of these platforms.read more
Citations
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Recent Advances in Design of Fluorescence-Based Assays for High-Throughput Screening
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Cellular delivery of enzyme-loaded DNA origami
Ari Ora,Erika Järvihaavisto,Hongbo Zhang,Henni Auvinen,Hélder A. Santos,Mauri A. Kostiainen,Veikko Linko +6 more
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Photoactive Metal-Organic Framework for the Reduction of Aryl Halides by the Synergistic Effect of Consecutive Photoinduced Electron-Transfer and Hydrogen-Atom-Transfer Processes.
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A DNA nanoswitch-controlled reversible nanosensor.
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