Emerging functions of the EGFR in cancer
TLDR
The canonical ligand‐induced EGFR signaling pathway is reviewed, with particular emphasis to its regulation by endocytosis and subversion in human tumors, and the most recent advances in uncovering noncanonical EGFR functions in stress‐induced trafficking, autophagy, and energy metabolism are focused on.About:
This article is published in Molecular Oncology.The article was published on 2018-01-01 and is currently open access. It has received 775 citations till now. The article focuses on the topics: Epidermal growth factor receptor & Autocrine signalling.read more
Citations
More filters
Journal ArticleDOI
THE JOURNAL OF BIOLOGICAL CHEMISTRY: The Biochemical Behavior of LeadL I. Influence of Calcium, Phosphorus, and Vitamin D on Lead in Blood and Bone
Journal ArticleDOI
Current trends and challenges in cancer management and therapy using designer nanomaterials
P. N. Navya,P. N. Navya,Anubhav Kaphle,Sangly P. Srinivas,Suresh K. Bhargava,Vincent M. Rotello,Hemant Kumar Daima,Hemant Kumar Daima,Hemant Kumar Daima +8 more
TL;DR: A range of nanomaterials which are currently being employed for anticancer therapies are summarized and the fundamental role of their physicochemical properties in cancer management is discussed to provide an outlook on the future of this important field.
Journal ArticleDOI
Nanoparticle-Based Drug Delivery in Cancer Therapy and Its Role in Overcoming Drug Resistance
Yihan Yao,Yunxiang Zhou,Lihong Liu,Yanyan Xu,Qiang Chen,Yali Wang,Shijie Wu,Yongchuan Deng,Jianmin Zhang,Anwen Shao +9 more
TL;DR: The roles of nanoparticles and hybrid nanoparticles for drug delivery in chemotherapy, targeted therapy, and immunotherapy are discussed and the targeting mechanism of nanoparticle-based drug delivery as well as its function on reversing drug resistance are described.
Journal ArticleDOI
Clinical update on head and neck cancer: molecular biology and ongoing challenges.
E. Alsahafi,Katheryn Begg,Ivano Amelio,Nina Raulf,Philippe Lucarelli,Thomas Sauter,Mahvash Tavassoli +6 more
TL;DR: This update aims to build on the earlier 2014 review by bringing up to date the understanding of the molecular biology of HNSCCs and provide insights into areas of ongoing research and perspectives for the future.
Journal ArticleDOI
Cell adhesion in cancer: Beyond the migration of single cells.
TL;DR: Recently discovered roles of adhesion molecules in collective cancer cell migration are highlighted and the utility of three-dimensional models in studying cell-cell adhesion is discussed, as well as recent therapeutic approaches targetingadhesion molecules.
References
More filters
Journal ArticleDOI
Cell signaling by receptor-tyrosine kinases
TL;DR: Understanding of the complex signaling networks downstream from RTKs and how alterations in these networks are translated into cellular responses provides an important context for therapeutically countering the effects of pathogenic RTK mutations in cancer and other diseases.
Journal ArticleDOI
Regulation of cancer cell metabolism
TL;DR: Interest in the topic of tumour metabolism has waxed and waned over the past century, but it has become clear that many of the signalling pathways that are affected by genetic mutations and the tumour microenvironment have a profound effect on core metabolism, making this topic once again one of the most intense areas of research in cancer biology.
Journal ArticleDOI
Gefitinib plus best supportive care in previously treated patients with refractory advanced non-small-cell lung cancer: results from a randomised, placebo-controlled, multicentre study (Iressa Survival Evaluation in Lung Cancer)
Nick Thatcher,Alex R. Chang,Purvish M. Parikh,José Rodrigues Pereira,Tudor Ciuleanu,Joachim von Pawel,Sumitra Thongprasert,Eng Huat Tan,Kristine Pemberton,Venice Archer,Kevin H Carroll +10 more
TL;DR: Treatment with gefitinib was not associated with significant improvement in survival in either coprimary population, and there was pronounced heterogeneity in survival outcomes between groups of patients, with some evidence of benefit among never-smokers and patients of Asian origin.
Journal ArticleDOI
Molecular mechanism and physiological functions of clathrin-mediated endocytosis
TL;DR: Clathrin-mediated endocytosis is the endocytic portal into cells through which cargo is packaged into vesicles with the aid of a clathrin coat and is fundamental to neurotransmission, signal transduction and the regulation of many plasma membrane activities and is thus essential to higher eukaryotic life.
Journal ArticleDOI
Fundamentals of cancer metabolism
TL;DR: A conceptual framework to understand how and why metabolic reprogramming occurs in tumor cells, and the mechanisms linking altered metabolism to tumorigenesis and metastasis will progressively support the development of new strategies to treat human cancer.