Emerging Role of Mast Cells and Macrophages in Cardiovascular and Metabolic Diseases
Jia-Ming Xu,Guo-Ping Shi +1 more
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TLDR
Reduced cardiovascular complications and improved metabolic symptoms in animals receiving over-the-counter antiallergy medications that stabilize mast cells open another era of mast cell biology and bring new hope to human patients suffering from these conditions.Abstract:
Mast cells are essential in allergic immune responses. Recent discoveries have revealed their direct participation in cardiovascular diseases and metabolic disorders. Although more sophisticated mechanisms are still unknown, data from animal studies suggest that mast cells act similarly to macrophages and other inflammatory cells and contribute to human diseases through cell–cell interactions and the release of proinflammatory cytokines, chemokines, and proteases to induce inflammatory cell recruitment, cell apoptosis, angiogenesis, and matrix protein remodeling. Reduced cardiovascular complications and improved metabolic symptoms in animals receiving over-the-counter antiallergy medications that stabilize mast cells open another era of mast cell biology and bring new hope to human patients suffering from these conditions.read more
Citations
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Mast cells in human adipose tissue: link with morbid obesity, inflammatory status, and diabetes.
Adeline Divoux,Sandrine Moutel,Christine Poitou,Danièle Lacasa,Nicolas Veyrie,Abdelhalim Aissat,Michel Arock,Michèle Guerre-Millo,Karine Clément +8 more
TL;DR: It is found that mast cells are activated in human adipose tissue and localized preferentially in fibrosis depots, a local condition that stimulates their inflammatory state.
Journal ArticleDOI
Macrophage imbalance (M1 vs. M2) and upregulation of mast cells in wall of ruptured human cerebral aneurysms: preliminary results
TL;DR: Findings suggest that macrophage M1/M2 imbalance and upregulation of mast cells may have a role in the progression of cerebral aneurysms to rupture.
Journal ArticleDOI
Mast Cells as Effectors in Atherosclerosis
TL;DR: The current knowledge on mast cell function in cardiovascular diseases is discussed and potential novel therapeutic strategies to prevent acute cardiovascular syndromes via targeting of mast cells are speculated on.
Journal ArticleDOI
Leptin Deficiency Shifts Mast Cells toward Anti-Inflammatory Actions and Protects Mice from Obesity and Diabetes by Polarizing M2 Macrophages
Yi Zhou,Yi Zhou,Xueqing Yu,Huimei Chen,Huimei Chen,Sara Sjöberg,Joséphine Roux,Lijun Zhang,Al-Habib Ivoulsou,Farid Bensaid,Cong-Lin Liu,Jian Liu,Jian Liu,Joan Tordjman,Karine Clément,Chih-Hao Lee,Gökhan S. Hotamisligil,Peter Libby,Guo-Ping Shi +18 more
TL;DR: It is demonstrated that leptin deficiency slants MCs toward anti-inflammatory functions, and adoptive transfer of leptin-deficient MCs expanded ex vivo mitigates diet-induced and pre-established obesity and diabetes in mice.
Journal ArticleDOI
Tissue resident macrophages: Key players in the pathogenesis of type 2 diabetes and its complications.
Reza Meshkani,Sanaz Vakili +1 more
TL;DR: Data from human and animal studies suggest that macrophages contribute to T2D complications through cell-cell interactions and the release of pro-inflammatory cytokines, chemokines, and proteases to induce inflammatory cell recruitment, cell apoptosis, angiogenesis, and matrix protein remodeling.
References
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