Journal ArticleDOI
Engineering probiotics for therapeutic applications: recent examples and translational outlook.
Nikhil Aggarwal,Amy M. Ehrenworth Breedon,Christina M. Davis,In Young Hwang,Matthew Wook Chang +4 more
TLDR
A set of features that may be incorporated into engineered probiotics to aid in clinical translation and ultimately, realizing the potential of these biotherapeutics are discussed.About:
This article is published in Current Opinion in Biotechnology.The article was published on 2020-10-01. It has received 59 citations till now.read more
Citations
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Journal ArticleDOI
Self-tunable engineered yeast probiotics for the treatment of inflammatory bowel disease
Benjamin M. Scott,Cristina Gutiérrez-Vázquez,Liliana Maria Sanmarco,Jessica A da Silva Pereira,Zhaorong Li,Agustin Plasencia,Patrick Hewson,Laura M. Cox,Madelynn O'Brien,Steven K Chen,Pedro M. Moraes-Vieira,Belinda S. W. Chang,Sergio G. Peisajovich,Sergio G. Peisajovich,Francisco J. Quintana,Francisco J. Quintana +15 more
TL;DR: In this article, yeast-based engineered probiotics that express a human P2Y2 purinergic receptor with up to a 1,000-fold increase in eATP sensitivity were developed.
Journal ArticleDOI
Function and therapeutic value of astrocytes in neurological diseases
TL;DR: In this article , the authors highlight general mechanisms of astrocyte regulation and their potential as therapeutic targets, including drugs that alter the metabolism of the cells and therapies that target transporters and receptors on the cells, and emerging ideas such as engineered probiotics and glia-to-neuron conversion therapies.
Journal ArticleDOI
Tweak to Treat: Reprograming Bacteria for Cancer Treatment.
TL;DR: The use of combination therapies comprising both engineered bacteria and conventional anticancer therapies for addressing intratumor heterogeneity and prospects for the development and clinical translation of engineered bacteria for cancer prevention and treatment are discussed.
Journal ArticleDOI
Systematic Quantification of Sequence and Structural Determinants Controlling mRNA stability in Bacterial Operons.
Daniel P. Cetnar,Howard M. Salis +1 more
TL;DR: In this article, the determinants that control mRNA decay rates remain poorly characterized, and a synthetic biolabel was applied to identify the determinant of mRNA degradation, which is a central process that affects all gene expression levels.
Journal ArticleDOI
Probiotic Effects against Virus Infections: New Weapons for an Old War.
Aroa Lopez-Santamarina,Alexandre Lamas,Alicia Del Carmen Mondragón,Alejandra Cardelle-Cobas,Patricia Regal,José Antonio Rodríguez-Ávila,José M. Miranda,Carlos Manuel Franco,Alberto Cepeda +8 more
TL;DR: In this paper, a review aimed to gather the available literature investigating the effects of probiotics against the most common viral infections using in vitro trials in cell lines and in vivo clinical trials in both experimental animals and humans.
References
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Journal ArticleDOI
Personalized Gut Mucosal Colonization Resistance to Empiric Probiotics Is Associated with Unique Host and Microbiome Features
Niv Zmora,Niv Zmora,Gili Zilberman-Schapira,Jotham Suez,Uria Mor,Mally Dori-Bachash,Stavros Bashiardes,Eran Kotler,Maya Zur,Dana Regev-Lehavi,Rotem Ben-Zeev Brik,Sara Federici,Yotam Cohen,Raquel Linevsky,Daphna Rothschild,Andreas E. Moor,Shani Ben-Moshe,Alon Harmelin,Shalev Itzkovitz,Nitsan Maharshak,Nitsan Maharshak,Oren Shibolet,Oren Shibolet,Hagit Shapiro,Meirav Pevsner-Fischer,Itai Sharon,Zamir Halpern,Zamir Halpern,Eran Segal,Eran Elinav +29 more
TL;DR: The metagenomically characterized the murine and human mucosal-associated gastrointestinal microbiome and found it to only partially correlate with stool microbiome, indicating that empiric probiotics supplementation may be limited in universally and persistently impacting the gut mucosa.
Journal ArticleDOI
The pros, cons, and many unknowns of probiotics
TL;DR: This Perspective highlights key advances, challenges and limitations in striving toward an unbiased interpretation of the large amount of data regarding over-the-counter probiotics, and proposes avenues to improve the quality of evidence, transparency, public awareness and regulation of their use.
Journal ArticleDOI
Probiotics: a role in the treatment of intestinal infection and inflammation?
TL;DR: Abundant evidence implies that specific strains selected from the healthy gut microflora exhibit powerful antipathogenic and anti-inflammatory capabilities, and are consequently involved with enhanced colonisation resistance in the intestine.
Journal ArticleDOI
Horizontal transfer of antibiotic resistance genes in clinical environments.
TL;DR: It is highlighted how 11 of the top 12 priority antibiotic-resistant pathogens are known or predicted to be naturally transformable, raising the possibility that this mechanism of HGT makes significant contributions to the spread of ARGs.
Journal ArticleDOI
An ingestible bacterial-electronic system to monitor gastrointestinal health.
Mark Mimee,Phillip Nadeau,Alison Hayward,Sean Carim,Sarah E. Flanagan,Logan Jerger,Logan Jerger,Joy Collins,Shane McDonnell,Richard Swartwout,Robert J. Citorik,Vladimir Bulovic,Robert Langer,Giovanni Traverso,Giovanni Traverso,Anantha P. Chandrakasan,Timothy K. Lu +16 more
TL;DR: An ingestible micro-bio-electronic device (IMBED) for in situ biomolecular detection based on environmentally resilient biosensor bacteria and miniaturized luminescence readout electronics that wirelessly communicate with an external device is presented.