Epidemiology of atopic dermatitis in adults: Results from an international survey.
Sébastien Barbarot,S. Auziere,Abhijit Gadkari,Giampiero Girolomoni,Lluís Puig,Eric L. Simpson,David J. Margolis,M S de Bruin-Weller,Laurent Eckert +8 more
TLDR
There are gaps in the authors' knowledge of the prevalence of adult atopic dermatitis (AD) and the need to investigate these gaps more fully.Abstract:
Background There are gaps in our knowledge of the prevalence of adult atopic dermatitis (AD). Objective To estimate the prevalence of AD in adults and by disease severity. Methods This international, cross-sectional, web-based survey was performed in the United States, Canada, France, Germany, Italy, Spain, United Kingdom, and Japan. Adult members of online respondent panels were sent a questionnaire for AD identification and severity assessment; demographic quotas ensured population representativeness for each country. A diagnosis of AD required subjects to be positive on the modified UK Working Party/ISAAC criteria and self-report of ever having an AD diagnosis by a physician. The proportion of subjects with AD who reported being treated for their condition was determined and also used to estimate prevalence. Severity scales were Patient-Oriented SCORAD, Patient-Orientated Eczema Measure, and Patient Global Assessment. Results Among participants by region, the point prevalence of adult AD in the overall/treated populations was 4.9%/3.9% in the US, 3.5%/2.6% in Canada, 4.4%/3.5% in the EU, and 2.1%/1.5% in Japan. The prevalence was generally lower for males vs females, and decreased with age. Regional variability was observed within countries. Severity varied by scale and region; however, regardless of the scale or region, proportion of subjects reporting severe disease was lower than mild or moderate disease. Conclusions Prevalence of adult AD ranged from 2.1% to 4.9% across countries. Severe AD represented a small proportion of the overall AD population regardless of measure or region.read more
Citations
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Baricitinib in patients with moderate-to-severe atopic dermatitis and inadequate response to topical corticosteroids: results from two randomized monotherapy phase III trials
Eric L. Simpson,Jean-Philippe Lacour,Lynda Spelman,R. Galimberti,Lawrence F. Eichenfield,Robert Bissonnette,Brett A. King,Jacob P. Thyssen,Jonathan I. Silverberg,T. Bieber,Kenji Kabashima,Y. Tsunemi,Antonio Costanzo,Emma Guttman-Yassky,Lisa A. Beck,Jonathan Janes,Amy M. DeLozier,Margaret Gamalo,Dennis Brinker,Tracy Cardillo,Fabio P. Nunes,Amy S. Paller,A. Wollenberg,Kristian Reich +23 more
TL;DR: Baricitinib, an oral selective Janus kinase 1 and 2 inhibitor, effectively reduced atopic dermatitis (AD) severity in a phase II study with concomitant topical corticosteroids.
Journal ArticleDOI
Tralokinumab for moderate‐to‐severe atopic dermatitis: results from two 52‐week, randomized, double‐blind, multicentre, placebo‐controlled phase III trials (ECZTRA 1 and ECZTRA 2)*
A. Wollenberg,Andrew Blauvelt,E. Guttman-Yassky,M. Worm,C Lynde,Jean-Philippe Lacour,Lynda Spelman,Norito Katoh,Hidehisa Saeki,Yves Poulin,A. Lesiak,Leon H Kircik,Leon H Kircik,S.H. Cho,Pedro Herranz,Michael J. Cork,Ketty Peris,Louise Abildgaard Steffensen,Bo Bang,Alexandra Kuznetsova,T.N. Jensen,M.L. Østerdal,Eric L. Simpson +22 more
TL;DR: Tralokinumab, a fully human monoclonal antibody, specifically neutralizes interleukin‐13, a key cytokine driving peripheral inflammation in atopic dermatitis (AD).
Journal ArticleDOI
Atopic Dermatitis in America Study: A Cross-Sectional Study Examining the Prevalence and Disease Burden of Atopic Dermatitis in the US Adult Population
Zelma C. Chiesa Fuxench,Julie Block,Mark Boguniewicz,John Boyle,Luz Fonacier,Joel M. Gelfand,Mitchell H. Grayson,David J. Margolis,Lynda Mitchell,Jonathan I. Silverberg,Lawrence B. Schwartz,Eric L. Simpson,Peck Y. Ong +12 more
TL;DR: The study confirms the high prevalence and disease burden of atopic dermatitis in the population of the United States, and the distribution of disease severity, and its impact on health-related quality of life.
Journal ArticleDOI
Prevalence and Incidence of Atopic Dermatitis: A Systematic Review.
TL;DR: Empirical studies of the prevalence and incidence of atopic dermatitis during childhood and adulthood, focusing on data from the 21st century are reviewed, finding few recent studies on incidence of AD in the 20th century and no studies on adults only.
Journal ArticleDOI
The global burden of atopic dermatitis: lessons from the Global Burden of Disease Study 1990-2017.
Melissa R. Laughter,Mayra B.C. Maymone,Soudeh Mashayekhi,B.W.M. Arents,Chante Karimkhani,Sinead Langan,Robert P. Dellavalle,Carsten Flohr +7 more
TL;DR: The Global Burden of Disease (GBD) Study provides an annually updated resource to study disease‐related morbidity and mortality worldwide.
References
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International Study of Asthma and Allergies in Childhood (ISAAC): rationale and methods.
M. I. Asher,U. Keil,H. R. Anderson,Richard Beasley,J. Crane,Fernando D. Martinez,Ed A. Mitchell,Neil Pearce,B. Sibbald,Alistair Stewart,David P. Strachan,Stephan K. Weiland,Hywel C Williams +12 more
TL;DR: The International Study of Asthma and Allergies in Childhood (ISAAC), was founded to maximize the value of epidemiological research into asthma and allergic disease, by establishing a standardized methodology and facilitating international collaboration.
Journal ArticleDOI
The U.K. Working Party's Diagnostic Criteria for Atopic Dermatitis. I. Derivation of a minimum set of discriminators for atopic dermatitis.
Hywel C Williams,P. G. J. Burney,Roderick J. Hay,C.B. Archer,M J Shipley,J J Hunter,E A Bingham,Andrew Yule Finlay,A.C. Pembroke,R.A.C. Graham-Brown +9 more
TL;DR: A working party of 13 dermatologists, two family practitioners and a paediatrician was assembled, with the aim of developing a minimum list of reliable discriminators for atopic dermatitis, finding that the discriminatory value of these criteria was satisfactory when tested against a further sample of 150 patients drawn from the community, who did not have skin disease.
Journal ArticleDOI
The eczema area and severity index (EASI): assessment of reliability in atopic dermatitis
Jon M. Hanifin,Thurston M,Thurston M,Omoto M,Omoto M,R. Cherill,R. Cherill,Susan J. Tofte,Graeber M,Graeber M +9 more
TL;DR: In this paper, the reliability of the EASI scoring system was evaluated by assessing inter-and intra-observer consistency, and the results indicated that the evaluators assessed the patients consistently across both study days.
Journal ArticleDOI
Progressive activation of T(H)2/T(H)22 cytokines and selective epidermal proteins characterizes acute and chronic atopic dermatitis.
Julia K. Gittler,Julia K. Gittler,Avner Shemer,Mayte Suárez-Fariñas,Judilyn Fuentes-Duculan,Kara J. Gulewicz,Claire Q.F. Wang,Hiroshi Mitsui,Irma Cardinale,Cristina de Guzman Strong,James G. Krueger,Emma Guttman-Yassky,Emma Guttman-Yassky +12 more
TL;DR: In this article, the authors investigated intrapersonal sets of transcriptomes from non-lesional skin and acute and chronic lesions of 10 patients with AD through genomic, molecular, and cellular profiling.
Journal ArticleDOI
The Psychological Burden of Skin Diseases: A Cross-Sectional Multicenter Study among Dermatological Out-Patients in 13 European Countries
Florence J Dalgard,Uwe Gieler,Lucia Tomas-Aragones,Lars Lien,Françoise Poot,Gregor B.E. Jemec,Laurent Misery,Csanád Szabó,Dennis Linder,Francesca Sampogna,Andrea W M Evers,Jon Anders Halvorsen,Flora Balieva,Jacek C Szepietowski,Dmitry Romanov,Servando E Marron,İlknur Kıvanç Altunay,Andrew Yule Finlay,Sam Salek,Jörg Kupfer +19 more
TL;DR: The association with depression and anxiety was highest for patients with psoriasis, atopic dermatitis, hand eczema, and leg ulcers, and only patients with Psoriasis had significant association with suicidal ideation.
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