Journal ArticleDOI
ERBB receptors and cancer: the complexity of targeted inhibitors.
Nancy E. Hynes,Heidi Lane +1 more
TLDR
This work discusses the significance of these receptors as clinical targets, in particular the molecular mechanisms underlying response, and many ERBB inhibitors used in the clinic.Abstract:
ERBB receptor tyrosine kinases have important roles in human cancer. In particular, the expression or activation of epidermal growth factor receptor and ERBB2 are altered in many epithelial tumours, and clinical studies indicate that they have important roles in tumour aetiology and progression. Accordingly, these receptors have been intensely studied to understand their importance in cancer biology and as therapeutic targets, and many ERBB inhibitors are now used in the clinic. We will discuss the significance of these receptors as clinical targets, in particular the molecular mechanisms underlying response.read more
Citations
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Therapeutic application of noncytotoxic molecular targeted therapy in gliomas: growth factor receptors and angiogenesis inhibitors.
TL;DR: Recent studies of bevacizumab, an anti-VEGF antibody, and irinotecan, a topoisomerase I inhibitor, have demonstrated a high response rate, suggesting that targeted antiangiogenic therapies may play a significant role in the management of high-grade gliomas in the future.
Journal ArticleDOI
Epidermal growth factor receptor and DNA double strand break repair: the cell's self-defence.
TL;DR: The reviewed observations point to a heretofore not understood mechanism of the cell's self-defence against X-rays which can be exploited in combined radio- and chemotherapy.
Journal ArticleDOI
Unravelling the molecular complexity of GPCR-mediated EGFR transactivation using functional genomics approaches.
TL;DR: Using an unbiased approach for identification of the molecules required for GPCR‐mediated EGFR transactivation will provide a contemporary and more complete representation from which to extrapolate therapeutic control in diseases from cardiovascular remodelling to cancer.
Journal ArticleDOI
Role of EGFR in the Nervous System.
Roberta Romano,Cecilia Bucci +1 more
TL;DR: The role of EGFR in regulating differentiation and functions of neurons and neuroglia is examined and its involvement in regeneration after injury and in the onset of neurodegenerative diseases is examined.
Journal ArticleDOI
Structural basis for EGFR ligand sequestration by Argos
TL;DR: The results indicate that undiscovered mammalian counterparts of Argos may exist among other poorly characterized structural homologues, and define requirements for the design of artificial EGF-sequestering proteins that would be valuable anti-cancer therapeutics.
References
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TL;DR: This work has been supported by the Department of the Army and the National Institutes of Health, and the author acknowledges the support and encouragement of the National Cancer Institute.
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Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib
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Use of Chemotherapy plus a Monoclonal Antibody against HER2 for Metastatic Breast Cancer That Overexpresses HER2
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TL;DR: Results suggest that EGFR mutations may predict sensitivity to gefitinib, and treatment with the EGFR kinase inhibitor gefitsinib causes tumor regression in some patients with NSCLC, more frequently in Japan.
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