Journal ArticleDOI
ERBB receptors and cancer: the complexity of targeted inhibitors.
Nancy E. Hynes,Heidi Lane +1 more
TLDR
This work discusses the significance of these receptors as clinical targets, in particular the molecular mechanisms underlying response, and many ERBB inhibitors used in the clinic.Abstract:
ERBB receptor tyrosine kinases have important roles in human cancer. In particular, the expression or activation of epidermal growth factor receptor and ERBB2 are altered in many epithelial tumours, and clinical studies indicate that they have important roles in tumour aetiology and progression. Accordingly, these receptors have been intensely studied to understand their importance in cancer biology and as therapeutic targets, and many ERBB inhibitors are now used in the clinic. We will discuss the significance of these receptors as clinical targets, in particular the molecular mechanisms underlying response.read more
Citations
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Cancer Genome Landscapes
Bert Vogelstein,Nickolas Papadopoulos,Victor E. Velculescu,Shibin Zhou,Luis A. Diaz,Kenneth W. Kinzler +5 more
TL;DR: This work has revealed the genomic landscapes of common forms of human cancer, which consists of a small number of “mountains” (genes altered in a high percentage of tumors) and a much larger number of "hills" (Genes altered infrequently).
Journal ArticleDOI
Radiotherapy plus Cetuximab for Squamous-Cell Carcinoma of the Head and Neck
James A. Bonner,Paul M. Harari,Jordi Giralt,Nozar Azarnia,Dong M. Shin,Roger B. Cohen,Christopher U. Jones,Ranjan Sur,David Raben,Jacek Jassem,Roger Ove,Merrill S. Kies,José Baselga,Hagop Youssoufian,Nadia Amellal,Eric K. Rowinsky,Eric K. Rowinsky,K. Kian Ang +17 more
TL;DR: Treatment of locoregionally advanced head and neck cancer with concomitant high-dose radiotherapy plus cetuximab improves locoreGional control and reduces mortality without increasing the common toxic effects associated with radiotherapy to the head andneck.
Journal ArticleDOI
Matrix Metalloproteinases: Regulators of the Tumor Microenvironment
TL;DR: In addition to their role in extracellular matrix turnover and cancer cell migration, MMPs regulate signaling pathways that control cell growth, inflammation, or angiogenesis and may even work in a nonproteolytic manner.
Journal ArticleDOI
A collection of breast cancer cell lines for the study of functionally distinct cancer subtypes
Richard M. Neve,Richard M. Neve,Koei Chin,Jane Fridlyand,Jennifer Yeh,Frederick L. Baehner,Tea Fevr,Laura Clark,Nora Bayani,Jean-Philippe Coppe,Frances Tong,Terence P. Speed,Paul T. Spellman,Sandy DeVries,Anna Lapuk,Nicholas J. Wang,Wen-Lin Kuo,Jackie L. Stilwell,Daniel Pinkel,Donna G. Albertson,F. M. Waldman,Frank McCormick,Robert B. Dickson,Michael D. Johnson,Marc E. Lippman,Stephen P. Ethier,Adi F. Gazdar,Joe W. Gray,Joe W. Gray +28 more
TL;DR: It is shown, using Trastuzumab (Herceptin) monotherapy as an example, that the system can be used to identify molecular features that predict or indicate response to targeted therapies or other physiological perturbations.
Journal ArticleDOI
Wild-type KRAS is required for panitumumab efficacy in patients with metastatic colorectal cancer
Rafael G. Amado,Michael S. Wolf,Marc Peeters,Eric Van Cutsem,Salvatore Siena,Daniel J. Freeman,Todd Juan,Robert Sikorski,Sid Suggs,Robert Radinsky,Scott D. Patterson,David D. Chang +11 more
TL;DR: Panitumumab monotherapy efficacy in mCRC is confined to patients with WT KRAS tumors, and KRAS status should be considered in selecting patients withmCRC as candidates for panitumuab mon Therapy.
References
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Journal ArticleDOI
Crystal Structure of the Complex of Human Epidermal Growth Factor and Receptor Extracellular Domains.
Hideo Ogiso,Ryuichiro Ishitani,Osamu Nureki,Shuya Fukai,Mari Yamanaka,Jaehoon Kim,Kazuki Saito,Ayako Sakamoto,Mio Inoue,Mikako Shirouzu,Shigeyuki Yokoyama +10 more
TL;DR: The crystal structure of a 2:2 complex of human EGF and the EGFR extracellular region has been determined at 3.3 A resolution and the unique "receptor-mediated dimerization" was verified by EGFR mutagenesis.
Journal ArticleDOI
Mechanisms of tamoxifen resistance: increased estrogen receptor-HER2/neu cross-talk in ER/HER2-positive breast cancer.
Jiang Shou,Suleiman Massarweh,C. Kent Osborne,A. E. Wakeling,Simale Ali,Heidi L. Weiss,Rachel Schiff +6 more
TL;DR: Gefitinib pretreatment eliminated tamoxifen's agonist effects, restored its antitumor activity both in vitro and in vivo in MCF-7/HER2-18 cells, and revealed molecular cross-talk between the ER and HER2 pathways was increased.
Journal ArticleDOI
Targeting the mitogen-activated protein kinase cascade to treat cancer
TL;DR: The RAS–mitogen activated protein kinase (MAPK) signalling pathway has long been viewed as an attractive pathway for anticancer therapies, based on its central role in regulating the growth and survival of cells from a broad spectrum of human tumours.
Journal ArticleDOI
Aberrant neural and cardiac development in mice lacking the ErbB4 neuregulin receptor.
Martin Gassmann,Franca Casagranda,Donata Orioli,Horst H. Simon,Cary Lai,Rüdiger Klein,Greg Lemke +6 more
TL;DR: It is demonstrated that ErbB4 is an essential in vivo regulator of both cardiac muscle differentiation and axon guidance in the central nervous system (CNS) and differences in the hindbrain phenotypes of these mutants are consistent with the action of a new Erb B4 ligand in the CNS.
Journal ArticleDOI
The ADAMs family of metalloproteases: multidomain proteins with multiple functions
TL;DR: This review will first discuss the properties of each of the domains of the ADAMs, then describe the involvement ofADAMs in selected biological processes, and highlight recent interesting findings suggesting roles for ADams in human disease.
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