Etiology of the Protein-Energy Wasting Syndrome in Chronic Kidney Disease: A Consensus Statement From the International Society of Renal Nutrition and Metabolism (ISRNM)
Juan Jesus Carrero,Peter Stenvinkel,Lilian Cuppari,T. Alp Ikizler,Kamyar Kalantar-Zadeh,George A. Kaysen,William E. Mitch,S. Russ Price,S. Russ Price,Christoph Wanner,Angela Yee-Moon Wang,Pieter ter Wee,Harold A. Franch,Harold A. Franch +13 more
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TLDR
This consensus statement of current knowledge on the etiology of PEW syndrome in CKD is provided to increase awareness, identify research needs, and provide the basis for future work to understand therapies and consequences of Pew.About:
This article is published in Journal of Renal Nutrition.The article was published on 2013-03-01 and is currently open access. It has received 628 citations till now. The article focuses on the topics: Wasting & Kidney disease.read more
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Latest consensus and update on protein-energy wasting in chronic kidney disease.
TL;DR: Prevention and treatment of PEW should involve individualized and integrated approaches to modulate identified risk factors and contributing comorbidities and show stronger associations with unfavorable outcomes than fat loss.
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Screening for muscle wasting and dysfunction in patients with chronic kidney disease
Juan Jesus Carrero,Kirsten L. Johansen,Bengt Lindholm,Peter Stenvinkel,Lilian Cuppari,Carla Maria Avesani +5 more
TL;DR: In this paper, a review of available methods for assessment of muscle mass and functionality, with an emphasis on their accuracy in the setting of CKD patients, is presented, and the selection of reference cutoffs for defining conditions of muscle wasting and dysfunction is discussed.
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The role of E3 ubiquitin-ligases MuRF-1 and MAFbx in loss of skeletal muscle mass.
Oren Rom,Abraham Z. Reznick +1 more
TL;DR: This review aims to explore the involvement of MuRF-1 and MAFbx in catabolism of skeletal muscle during various pathologies, such as cancer cachexia, sarcopenia of aging, chronic kidney disease, diabetes, and chronic obstructive pulmonary disease.
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Sarcopenia and its individual criteria are associated, in part, with mortality among patients on hemodialysis.
Piyawan Kittiskulnam,Piyawan Kittiskulnam,Glenn M. Chertow,Juan Jesus Carrero,Cynthia Delgado,George A. Kaysen,Kirsten L. Johansen +6 more
TL;DR: Physical performance measures, including slow gait speed and weak hand grip strength, were associated with mortality even after adjustment for muscle size and other confounders, and neither sarcopenia nor low muscle mass by itself was a better predictor of mortality than functional limitation alone in patients receiving hemodialysis.
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Muscle wasting in end-stage renal disease promulgates premature death: established, emerging and potential novel treatment strategies
TL;DR: Recent studies on stimulation of mitochondrial biogenesis, myogenic stem (satellite) cells and manipulation of transforming growth factor family members hold promise for more effective therapies to target muscle mass loss and function in the future.
References
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William J. Evans,John E. Morley,Josep M. Argilés,Connie W. Bales,Vickie E. Baracos,Denis Guttridge,Aminah Jatoi,Kamyar Kalantar-Zadeh,H. Lochs,Giovanni Mantovani,Daniel L. Marks,William E. Mitch,Maurizio Muscaritoli,Armine Najand,Piotr Ponikowski,Filippo Rossi Fanelli,Morrie Schambelan,Annemie M. W. J. Schols,Michael W. Schuster,David R. Thomas,Robert R. Wolfe,Stefan D. Anker +21 more
TL;DR: The prominent clinical feature of cachexia is weight loss in adults (corrected for fluid retention) or growth failure in children (excluding endocrine disorders).
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A proposed nomenclature and diagnostic criteria for protein–energy wasting in acute and chronic kidney disease
Denis Fouque,Kamyar Kalantar-Zadeh,Joel D. Kopple,Noël Cano,Philippe Chauveau,Lilian Cuppari,Harold A. Franch,Gabriele Guarnieri,Talat Alp Ikizler,George A. Kaysen,Bengt Lindholm,Ziad A. Massy,William E. Mitch,E. Pineda,Peter Stenvinkel,A. Trevinho-Becerra,Christoph Wanner +16 more
TL;DR: An expert panel to review and develop standard terminologies and definitions related to wasting, cachexia, malnutrition, and inflammation in CKD and AKI recommends the term 'protein-energy wasting' for loss of body protein mass and fuel reserves.
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Multiple types of skeletal muscle atrophy involve a common program of changes in gene expression
Stewart H. Lecker,R. Thomas Jagoe,Alexander Gilbert,Marcelo Gomes,Vickie E. Baracos,James L. Bailey,S. Russ Price,William E. Mitch,Alfred L. Goldberg +8 more
TL;DR: Different types of skeletal muscle atrophy share a common transcriptional program that is activated in many systemic diseases including diabetes, cancer, and renal failure, according to cDNA microarrays.
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Cytokines and major depression.
TL;DR: Although the central effects of proinflammatory cytokines appear to be able to account for most of the symptoms occurring in depression, it remains to be established whether cytokines play a causal role in depressive illness or represent epiphenomena without major significance.