Eukaryotic ribosome biogenesis at a glance.
TLDR
This Cell Science at a Glance article and the accompanying poster summarise the current knowledge on eukaryotic ribosome biogenesis, with an emphasis on the yeast model system.Abstract:
Ribosomes play a pivotal role in the molecular life of every cell. Moreover, synthesis of ribosomes is one of the most energetically demanding of all cellular processes. In eukaryotic cells, ribosome biogenesis requires the coordinated activity of all three RNA polymerases and the orchestrated work of many (>200) transiently associated ribosome assembly factors. The biogenesis of ribosomes is a tightly regulated activity and it is inextricably linked to other fundamental cellular processes, including growth and cell division. Furthermore, recent studies have demonstrated that defects in ribosome biogenesis are associated with several hereditary diseases. In this Cell Science at a Glance article and the accompanying poster, we summarise the current knowledge on eukaryotic ribosome biogenesis, with an emphasis on the yeast model system.read more
Citations
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A census of human RNA-binding proteins.
TL;DR: This work presents a census of 1,542 manually curated RBPs that are analysed for their interactions with different classes of RNA, their evolutionary conservation, their abundance and their tissue-specific expression, a critical step towards the comprehensive characterization of proteins involved in human RNA metabolism.
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Circular non-coding RNA ANRIL modulates ribosomal RNA maturation and atherosclerosis in humans.
Lesca M. Holdt,Anika Stahringer,Kristina Sass,Garwin Pichler,Nils A. Kulak,Wolfgang Wilfert,Alexander Kohlmaier,Andreas Herbst,Bernd H. Northoff,Alexandros Nicolaou,Gabor Gäbel,Frank Beutner,Markus Scholz,Joachim Thiery,Kiran Musunuru,Knut Krohn,Matthias Mann,Daniel Teupser,Daniel Teupser +18 more
TL;DR: These findings identify circANRIL as a prototype of a circRNA regulating ribosome biogenesis and conferring atheroprotection, thereby showing that circularization of long non-coding RNAs may alter RNA function and protect from human disease.
Journal ArticleDOI
Tuning the ribosome: The influence of rRNA modification on eukaryotic ribosome biogenesis and function
Katherine E. Sloan,Ahmed S. Warda,Sunny Sharma,Karl-Dieter Entian,Denis L. J. Lafontaine,Markus T. Bohnsack +5 more
TL;DR: Changes in the rRNA modification pattern have been observed in response to environmental changes, during development, and in disease, which suggests that rRNA modifications may contribute to the translational control of gene expression.
Journal ArticleDOI
N 6- Methyladenosine methyltransferase ZCCHC4 mediates ribosomal RNA methylation
Honghui Ma,Honghui Ma,Honghui Ma,Xiaoyun Wang,Jia-Bin Cai,Qing Dai,Qing Dai,S. Kundhavai Natchiar,Ruitu Lv,Kai Chen,Kai Chen,Zhike Lu,Zhike Lu,Hao Chen,Yujiang Geno Shi,Yujiang Geno Shi,Fei Lan,Jia Fan,Bruno P. Klaholz,Tao Pan,Yang Shi,Yang Shi,Chuan He,Chuan He +23 more
TL;DR: A new m6A methyltransferase, ZCCHC4, is reported, which primarily methylates human 28S rRNA and also interacts with a subset of mRNAs, and was identified as a mammalian ribosome RNA (rRNA) N6-methyladenosine (m6A) writer protein that installs m 6A 4220 in 28s rRNA.
Journal ArticleDOI
A deep proteomics perspective on CRM1-mediated nuclear export and nucleocytoplasmic partitioning.
Koray Kirli,Samir Karaca,Heinz Jürgen Dehne,Matthias Samwer,Kuan-Ting Pan,Christof Lenz,Christof Lenz,Henning Urlaub,Henning Urlaub,Dirk Görlich +9 more
TL;DR: The data suggest new CRM1 functions in spatial control of vesicle coat-assembly, centrosomes, autophagy, peroxisome biogenesis, cytoskeleton, ribosome maturation, translation, mRNA degradation, and more generally in precluding a potentially detrimental action of cytoplasmic pathways within the nuclear interior.
References
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