Evaluation, Diagnosis, and Treatment of Gastrointestinal Disorders in Individuals With ASDs: A Consensus Report
Timothy Buie,Daniel B. Campbell,George J. Fuchs,Glenn T. Furuta,Glenn T. Furuta,Joseph Levy,Judy VandeWater,Agnes H. Whitaker,Dan Atkins,Dan Atkins,Margaret L. Bauman,Arthur L. Beaudet,Edward G. Carr,Michael D. Gershon,Susan L. Hyman,Pipop Jirapinyo,Harumi Jyonouchi,Koorosh Kooros,Rafail I. Kushak,Pat Levitt,Susan E. Levy,Jeffery D. Lewis,Katherine F. Murray,Marvin R. Natowicz,Aderbal Sabra,Barry K. Wershil,Sharon C. Weston,Lonnie K. Zeltzer,Harland S. Winter +28 more
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TLDR
The consensus expert opinion of the panel was that individuals with ASDs deserve the same thoroughness and standard of care in the diagnostic workup and treatment of gastrointestinal concerns as should occur for patients without ASDs.Abstract:
Autism spectrum disorders (ASDs) are common and clinically heterogeneous neurodevelopmental disorders. Gastrointestinal disorders and associated symptoms are commonly reported in individuals with ASDs, but key issues such as the prevalence and best treatment of these conditions are incompletely understood. A central difficulty in recognizing and characterizing gastrointestinal dysfunction with ASDs is the communication difficulties experienced by many affected individuals. A multidisciplinary panel reviewed the medical literature with the aim of generating evidence-based recommendations for diagnostic evaluation and management of gastrointestinal problems in this patient population. The panel concluded that evidence-based recommendations are not yet available. The consensus expert opinion of the panel was that individuals with ASDs deserve the same thoroughness and standard of care in the diagnostic workup and treatment of gastrointestinal concerns as should occur for patients without ASDs. Care providers should be aware that problem behavior in patients with ASDs may be the primary or sole symptom of the underlying medical condition, including some gastrointestinal disorders. For these patients, integration of behavioral and medical care may be most beneficial. Priorities for future research are identified to advance our understanding and management of gastrointestinal disorders in persons with ASDs.read more
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Gluten- and casein-free dietary intervention for autism spectrum conditions.
Paul Whiteley,Paul Shattock,Ann-Mari Knivsberg,Anders Seim,Karl L. Reichelt,Lynda Todd,Kevin Carr,Malcolm Hooper +7 more
TL;DR: Evidence suggestive that a gluten-free or casein-free diet can ameliorate core and peripheral symptoms and improve developmental outcome in some cases of autism spectrum conditions is examined.
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Amino Acid Dysregulation Metabotypes: Potential Biomarkers for Diagnosis and Individualized Treatment for Subtypes of Autism Spectrum Disorder
Alan M. Smith,Joseph J. King,Paul R. West,Michael Ludwig,Elizabeth L.R. Donley,Robert E. Burrier,David G. Amaral +6 more
TL;DR: This is the first article to report results from the Children's Autism Metabolome Project (CAMP), a large-scale effort to define autism biomarkers based on metabolomic analyses of blood samples from young children.
Journal ArticleDOI
A modified ketogenic gluten-free diet with MCT improves behavior in children with autism spectrum disorder.
Ryan W.Y. Lee,Ryan W.Y. Lee,Michael J. Corley,Alina Pang,Gaye Arakaki,Lisa Abbott,Michael Nishimoto,Rob Miyamoto,Erica Lee,Susan Yamamoto,Alika K. Maunakea,Annette Lum-Jones,Miki Wong +12 more
TL;DR: A modified gluten-free ketogenic diet with supplemental MCT is a potentially beneficial treatment option to improve the core features of autism spectrum disorder and warrants further investigation.
Journal ArticleDOI
Autism, Gastrointestinal Symptoms and Modulation of Gut Microbiota by Nutritional Interventions.
Maria Vittoria Ristori,Andrea Quagliariello,Sofia Reddel,Gianluca Ianiro,Stefano Vicari,Antonio Gasbarrini,Lorenza Putignani +6 more
TL;DR: The role that nutritional intervention can have on GI microbiota composition and thus on its influence on behavior, GI symptoms and microbiota composition is investigated and which are the beneficial effect on ASD conditions are reported.
Journal ArticleDOI
Autism spectrum disorders: a pediatric overview and update.
Alexis Tchaconas,Andrew Adesman +1 more
TL;DR: An updated overview of autism spectrum disorders (ASDs), with particular attention to the pediatrician's role in assessing and managing patients with ASDs, is provided with an emphasis on the clinical considerations relating to screening, evaluation, and management.
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