Evaluation, Diagnosis, and Treatment of Gastrointestinal Disorders in Individuals With ASDs: A Consensus Report
Timothy Buie,Daniel B. Campbell,George J. Fuchs,Glenn T. Furuta,Glenn T. Furuta,Joseph Levy,Judy VandeWater,Agnes H. Whitaker,Dan Atkins,Dan Atkins,Margaret L. Bauman,Arthur L. Beaudet,Edward G. Carr,Michael D. Gershon,Susan L. Hyman,Pipop Jirapinyo,Harumi Jyonouchi,Koorosh Kooros,Rafail I. Kushak,Pat Levitt,Susan E. Levy,Jeffery D. Lewis,Katherine F. Murray,Marvin R. Natowicz,Aderbal Sabra,Barry K. Wershil,Sharon C. Weston,Lonnie K. Zeltzer,Harland S. Winter +28 more
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The consensus expert opinion of the panel was that individuals with ASDs deserve the same thoroughness and standard of care in the diagnostic workup and treatment of gastrointestinal concerns as should occur for patients without ASDs.Abstract:
Autism spectrum disorders (ASDs) are common and clinically heterogeneous neurodevelopmental disorders. Gastrointestinal disorders and associated symptoms are commonly reported in individuals with ASDs, but key issues such as the prevalence and best treatment of these conditions are incompletely understood. A central difficulty in recognizing and characterizing gastrointestinal dysfunction with ASDs is the communication difficulties experienced by many affected individuals. A multidisciplinary panel reviewed the medical literature with the aim of generating evidence-based recommendations for diagnostic evaluation and management of gastrointestinal problems in this patient population. The panel concluded that evidence-based recommendations are not yet available. The consensus expert opinion of the panel was that individuals with ASDs deserve the same thoroughness and standard of care in the diagnostic workup and treatment of gastrointestinal concerns as should occur for patients without ASDs. Care providers should be aware that problem behavior in patients with ASDs may be the primary or sole symptom of the underlying medical condition, including some gastrointestinal disorders. For these patients, integration of behavioral and medical care may be most beneficial. Priorities for future research are identified to advance our understanding and management of gastrointestinal disorders in persons with ASDs.read more
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Vitamin A deficiency increases the risk of gastrointestinal comorbidity and exacerbates core symptoms in children with autism spectrum disorder.
TL;DR: The interaction of VAD and GI symptoms appeared to aggravate some of the core symptoms of children with ASD, and ASD children with GI comorbidities also have more serious core symptoms than ASD children without GI comerbidities.
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Urine proteome analysis to evaluate protein biomarkers in children with autism.
TL;DR: All the autistic children showed significant increase in urinary kininogen level measured quantitatively by ELISA, when compared to normal children, and the possibility of this protein as a diagnostic marker need further investigation.
Journal ArticleDOI
Breast Milk Protects Against Gastrointestinal Symptoms in Infants at High Risk for Autism During Early Development.
Alexander H. Penn,Leslie J. Carver,Carrie A. Herbert,Tiffany S. Lai,Melissa J. McIntire,Jeffrey T. Howard,Sharon F. Taylor,Geert W. Schmid-Schönbein,Karen R. Dobkins +8 more
TL;DR: Late weaning and exclusive breast milk were associated with protection against GI symptoms in high-risk infants, suggesting that GI dysfunction during early infant development may be a part of the ASD endophenotype.
Journal ArticleDOI
Variations in Mitochondrial Respiration Differ in IL-1ß/IL-10 Ratio Based Subgroups in Autism Spectrum Disorders.
TL;DR: An association between PBMC mitochondrial function and PBMo cytokine profiles in ASD subjects is indicated for the first time, which may indicate alteration in molecular pathways affecting both the immune system and mitochondrial function in some ASD subjects.
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Autoimmune and gastrointestinal dysfunctions: does a subset of children with autism reveal a broader connection?
Amy C. Brown,Lewis Mehl-Madrona +1 more
TL;DR: Sufficient evidence exists to support that a subgroup of children with autism may suffer from concomitant immune-related GI symptoms, and the available literature on the immunological and GI aspects of autism is evaluated.
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