Evaluation, Diagnosis, and Treatment of Gastrointestinal Disorders in Individuals With ASDs: A Consensus Report
Timothy Buie,Daniel B. Campbell,George J. Fuchs,Glenn T. Furuta,Glenn T. Furuta,Joseph Levy,Judy VandeWater,Agnes H. Whitaker,Dan Atkins,Dan Atkins,Margaret L. Bauman,Arthur L. Beaudet,Edward G. Carr,Michael D. Gershon,Susan L. Hyman,Pipop Jirapinyo,Harumi Jyonouchi,Koorosh Kooros,Rafail I. Kushak,Pat Levitt,Susan E. Levy,Jeffery D. Lewis,Katherine F. Murray,Marvin R. Natowicz,Aderbal Sabra,Barry K. Wershil,Sharon C. Weston,Lonnie K. Zeltzer,Harland S. Winter +28 more
Reads0
Chats0
TLDR
The consensus expert opinion of the panel was that individuals with ASDs deserve the same thoroughness and standard of care in the diagnostic workup and treatment of gastrointestinal concerns as should occur for patients without ASDs.Abstract:
Autism spectrum disorders (ASDs) are common and clinically heterogeneous neurodevelopmental disorders. Gastrointestinal disorders and associated symptoms are commonly reported in individuals with ASDs, but key issues such as the prevalence and best treatment of these conditions are incompletely understood. A central difficulty in recognizing and characterizing gastrointestinal dysfunction with ASDs is the communication difficulties experienced by many affected individuals. A multidisciplinary panel reviewed the medical literature with the aim of generating evidence-based recommendations for diagnostic evaluation and management of gastrointestinal problems in this patient population. The panel concluded that evidence-based recommendations are not yet available. The consensus expert opinion of the panel was that individuals with ASDs deserve the same thoroughness and standard of care in the diagnostic workup and treatment of gastrointestinal concerns as should occur for patients without ASDs. Care providers should be aware that problem behavior in patients with ASDs may be the primary or sole symptom of the underlying medical condition, including some gastrointestinal disorders. For these patients, integration of behavioral and medical care may be most beneficial. Priorities for future research are identified to advance our understanding and management of gastrointestinal disorders in persons with ASDs.read more
Citations
More filters
Journal ArticleDOI
Emerging biomarkers in autism spectrum disorder: a systematic review.
Richard E. Frye,Richard E. Frye,Sarah Vassall,Gurjot Kaur,Christina Lewis,Mohammand Karim,Mohammand Karim,Daniel A. Rossignol +7 more
TL;DR: A systematic review of the literature on ASD to identify promising biomarkers and rated the biomarkers in regards to a Level of Evidence and Grade of Recommendation using the Oxford Centre for Evidence-Based Medicine scale.
Journal ArticleDOI
The association between emotional and behavioral problems and gastrointestinal symptoms among children with high-functioning autism
TL;DR: This study investigated the association between gastrointestinal symptoms and a broad set of emotional and behavioral concerns in 95 children with high-functioning autism and IQ scores ≥ 80 and found that participants with gastrointestinal problems had significantly higher levels of affective problems.
Journal ArticleDOI
Serotonin as a link between the gut-brain-microbiome axis in autism spectrum disorders
TL;DR: The role of serotonin in ASD from the perspective of the ENS is reviewed because a murine model that has been demonstrated to possess brain, behavioral and GI abnormalities mimicking those seen in ASD harbors the most common serotonin transporter (SERT) based mutation found in children with ASD.
Journal ArticleDOI
Irritability and Problem Behavior in Autism Spectrum Disorder: A Practice Pathway for Pediatric Primary Care
Kelly McGuire,Kelly McGuire,Lawrence K. Fung,Louis P. Hagopian,Roma A. Vasa,Rajneesh Mahajan,Pilar Bernal,Anna E. Silberman,Audrey E Wolfe,Daniel L. Coury,Antonio Y. Hardan,Jeremy Veenstra-VanderWeele,Jeremy Veenstra-VanderWeele,Agnes H. Whitaker +13 more
TL;DR: The pediatric PCP caring for the patient with ASD is in a unique position to help generate an individualized treatment plan that targets factors contributing to I/PB and to implement this plan in collaboration with parents, schools, and other providers.
Journal ArticleDOI
Microbiome and nutrition in autism spectrum disorder: current knowledge and research needs.
TL;DR: The current evidence base regarding the gut environment and nutritional status of children with ASD is reviewed and potential underlying mechanisms of the microbiota-gut-brain axis in ASD and the interplay between nutrition, microbiota, and ASD symptoms are reviewed.
References
More filters
Journal ArticleDOI
GRADE: an emerging consensus on rating quality of evidence and strength of recommendations
Gordon H. Guyatt,Andrew D Oxman,Gunn Elisabeth Vist,Regina Kunz,Yngve Falck-Ytter,Pablo Alonso-Coello,Holger J. Schünemann +6 more
TL;DR: The advantages of the GRADE system are explored, which is increasingly being adopted by organisations worldwide and which is often praised for its high level of consistency.
Journal ArticleDOI
Grading quality of evidence and strength of recommendations.
David C. Atkins,Dana Best,Peter A. Briss,Martin P Eccles,Yngve Falck-Ytter,Signe Flottorp,Gordon H. Guyatt,Robin Harbour,Margaret C Haugh,David Henry,Suzanne Hill,Roman Jaeschke,Gillian Leng,Alessandro Liberati,Nicola Magrini,James Mason,Philippa Middleton,Jacek Mrukowicz,Dianne L. O'Connell,Andrew D Oxman,Bob Phillips,Holger J. Schünemann,Tessa Tan-Torres Edejer,H. Varonen,Gunn Elisabeth Vist,John W Williams,Stephanie Zaza +26 more
TL;DR: A system for grading the quality of evidence and the strength of recommendations that can be applied across a wide range of interventions and contexts is developed, and a summary of the approach from the perspective of a guideline user is presented.
Journal ArticleDOI
Prevalence of overweight and obesity among us children, adolescents, and adults, 1999-2002
Allison A. Hedley,Cynthia L. Ogden,Clifford L. Johnson,Margaret D. Carroll,Lester R. Curtin,Katherine M. Flegal +5 more
TL;DR: The NHANES results indicate continuing disparities by sex and between racial/ethnic groups in the prevalence of overweight and obesity among adults and overweight among children, using the most recent national data of height and weight measurements.
Journal ArticleDOI
Ileal-lymphoid-nodular hyperplasia, non-specific colitis, and pervasive developmental disorder in children
Andrew J. Wakefield,S. H. Murch,A Anthony,J Linnell,D M Casson,M Malik,M Berelowitz,Ap Dhillon,Mike Thomson,Peter Harvey,A Valentine,S Davies,J A Walker-Smith +12 more
TL;DR: In this paper, the authors investigated a consecutive series of children with chronic enterocolitis and regressive developmental disorder, and identified associated gastrointestinal disease and developmental regression in a group of previously normal children, which was generally associated in time with possible environmental triggers.
Journal ArticleDOI
Neuroglial activation and neuroinflammation in the brain of patients with autism
Diana L. Vargas,Caterina Nascimbene,Caterina Nascimbene,Chitra Krishnan,Andrew W. Zimmerman,Andrew W. Zimmerman,Carlos A. Pardo +6 more
TL;DR: It is indicated that innate neuroimmune reactions play a pathogenic role in an undefined proportion of autistic patients, suggesting that future therapies might involve modifying neuroglial responses in the brain.