Evaluation, Diagnosis, and Treatment of Gastrointestinal Disorders in Individuals With ASDs: A Consensus Report
Timothy Buie,Daniel B. Campbell,George J. Fuchs,Glenn T. Furuta,Glenn T. Furuta,Joseph Levy,Judy VandeWater,Agnes H. Whitaker,Dan Atkins,Dan Atkins,Margaret L. Bauman,Arthur L. Beaudet,Edward G. Carr,Michael D. Gershon,Susan L. Hyman,Pipop Jirapinyo,Harumi Jyonouchi,Koorosh Kooros,Rafail I. Kushak,Pat Levitt,Susan E. Levy,Jeffery D. Lewis,Katherine F. Murray,Marvin R. Natowicz,Aderbal Sabra,Barry K. Wershil,Sharon C. Weston,Lonnie K. Zeltzer,Harland S. Winter +28 more
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TLDR
The consensus expert opinion of the panel was that individuals with ASDs deserve the same thoroughness and standard of care in the diagnostic workup and treatment of gastrointestinal concerns as should occur for patients without ASDs.Abstract:
Autism spectrum disorders (ASDs) are common and clinically heterogeneous neurodevelopmental disorders. Gastrointestinal disorders and associated symptoms are commonly reported in individuals with ASDs, but key issues such as the prevalence and best treatment of these conditions are incompletely understood. A central difficulty in recognizing and characterizing gastrointestinal dysfunction with ASDs is the communication difficulties experienced by many affected individuals. A multidisciplinary panel reviewed the medical literature with the aim of generating evidence-based recommendations for diagnostic evaluation and management of gastrointestinal problems in this patient population. The panel concluded that evidence-based recommendations are not yet available. The consensus expert opinion of the panel was that individuals with ASDs deserve the same thoroughness and standard of care in the diagnostic workup and treatment of gastrointestinal concerns as should occur for patients without ASDs. Care providers should be aware that problem behavior in patients with ASDs may be the primary or sole symptom of the underlying medical condition, including some gastrointestinal disorders. For these patients, integration of behavioral and medical care may be most beneficial. Priorities for future research are identified to advance our understanding and management of gastrointestinal disorders in persons with ASDs.read more
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Risperidone-Related Improvement of Irritability in Children with Autism Is not Associated with Changes in Serum of Epidermal Growth Factor and Interleukin-13
Zuzana Tobiasova,Klaas H. B. van der Lingen,Lawrence Scahill,James F. Leckman,Yan Zhang,Wook-Jin Chae,James T. McCracken,Christopher J. McDougle,Benedetto Vitiello,Elaine Tierney,Michael G. Aman,L. Eugene Arnold,Liliya Katsovich,Pieter J. Hoekstra,Fred R. Volkmar,Alfred L. M. Bothwell,Ivana Kawikova +16 more
TL;DR: Risperidone-induced clinical improvement in subjects with autism was not associated with changes in the serum inflammatory markers measured, and altered levels of EGF and IL-13 play a role in the pathogenesis or phenotype of autism requires further investigation.
Journal ArticleDOI
Specificity of gut microbiota in children with autism spectrum disorder in Slovakia and its correlation with astrocytes activity marker and specific behavioural patterns.
Aleksandra Tomova,Katarína Šoltys,Gabriela Repiská,Lenka Pálková,D. Filcikova,Gabriel Minarik,Jan Turna,K. Prochotska,Katarina Babinska,Daniela Ostatníková +9 more
TL;DR: Distinct faecal microbiota in children with ASD was found to be more heterogeneous compared to that in neurotypical children and different bacterial abundance and correlation with behavioural and GI manifestations revealed several bacterial genera possibly important for ASD.
Journal ArticleDOI
Serological screening for Celiac Disease in 382 pre-schoolers with Autism Spectrum Disorder
Sara Calderoni,Elisa Santocchi,Teresa Del Bianco,Elena Brunori,Laura Caponi,Aldo Paolicchi,Francesca Fulceri,Margherita Prosperi,Antonio Narzisi,Angela Cosenza,Raffaella Tancredi,Filippo Muratori +11 more
TL;DR: Investigating the overall CD prevalence in a large population of pre-schoolers with ASD referred to a tertiary care University Hospital suggests the importance of regular screening for CD in young patients with ASD, and is of relevance for clinical and public health.
Journal ArticleDOI
Prenatal and Postnatal Epigenetic Programming: Implications for GI, Immune, and Neuronal Function in Autism
Mostafa I. Waly,Mady Hornig,Malav Suchin Trivedi,Nathaniel Hodgson,Radhika Kini,Akio Ohta,Richard C. Deth +6 more
TL;DR: It is proposed that neurodevelopmental, GI, and immune aspects of autism each reflect manifestations of inadequate antioxidant capacity, secondary to impaired cysteine uptake by the GI tract.
Journal ArticleDOI
Comorbidity Burden in Adults With Autism Spectrum Disorders and Intellectual Disabilities-A Report From the EFAAR (Frailty Assessment in Ageing Adults With Autism Spectrum and Intellectual Disabilities) Study
Stéphanie Miot,Stéphanie Miot,Tasnime N. Akbaraly,Tasnime N. Akbaraly,Tasnime N. Akbaraly,Cécile Michelon,Sylvie Couderc,Sophie Crepiat,Julie Loubersac,Marie-Christine Picot,Eric Pernon,Véronique Gonnier,Claude Jeandel,Hubert Blain,Amaria Baghdadli,Amaria Baghdadli +15 more
TL;DR: The severity of the comorbidity burden associated with premature ageing in adults with ASD and ID highlight their crucial need of personalized medical care.
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