Evaluation, Diagnosis, and Treatment of Gastrointestinal Disorders in Individuals With ASDs: A Consensus Report
Timothy Buie,Daniel B. Campbell,George J. Fuchs,Glenn T. Furuta,Glenn T. Furuta,Joseph Levy,Judy VandeWater,Agnes H. Whitaker,Dan Atkins,Dan Atkins,Margaret L. Bauman,Arthur L. Beaudet,Edward G. Carr,Michael D. Gershon,Susan L. Hyman,Pipop Jirapinyo,Harumi Jyonouchi,Koorosh Kooros,Rafail I. Kushak,Pat Levitt,Susan E. Levy,Jeffery D. Lewis,Katherine F. Murray,Marvin R. Natowicz,Aderbal Sabra,Barry K. Wershil,Sharon C. Weston,Lonnie K. Zeltzer,Harland S. Winter +28 more
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TLDR
The consensus expert opinion of the panel was that individuals with ASDs deserve the same thoroughness and standard of care in the diagnostic workup and treatment of gastrointestinal concerns as should occur for patients without ASDs.Abstract:
Autism spectrum disorders (ASDs) are common and clinically heterogeneous neurodevelopmental disorders. Gastrointestinal disorders and associated symptoms are commonly reported in individuals with ASDs, but key issues such as the prevalence and best treatment of these conditions are incompletely understood. A central difficulty in recognizing and characterizing gastrointestinal dysfunction with ASDs is the communication difficulties experienced by many affected individuals. A multidisciplinary panel reviewed the medical literature with the aim of generating evidence-based recommendations for diagnostic evaluation and management of gastrointestinal problems in this patient population. The panel concluded that evidence-based recommendations are not yet available. The consensus expert opinion of the panel was that individuals with ASDs deserve the same thoroughness and standard of care in the diagnostic workup and treatment of gastrointestinal concerns as should occur for patients without ASDs. Care providers should be aware that problem behavior in patients with ASDs may be the primary or sole symptom of the underlying medical condition, including some gastrointestinal disorders. For these patients, integration of behavioral and medical care may be most beneficial. Priorities for future research are identified to advance our understanding and management of gastrointestinal disorders in persons with ASDs.read more
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Early Intervention for Children With Autism Spectrum Disorder Under 3 Years of Age: Recommendations for Practice and Research
Lonnie Zwaigenbaum,Margaret L. Bauman,Roula Choueiri,Connie Kasari,Alice S. Carter,Doreen Granpeesheh,Zoe Mailloux,Susanne Smith Roley,Sheldon L. Wagner,Deborah Fein,Karen Pierce,Timothy Buie,Patricia A. Davis,Craig J. Newschaffer,Diana L. Robins,Amy M. Wetherby,Wendy L. Stone,Nurit Yirmiya,Annette Estes,Robin L Hansen,James C. McPartland,Marvin R. Natowicz +21 more
TL;DR: This article reviews current evidence for autism spectrum disorder interventions for children aged <3 years, based on peer-reviewed articles published up to December 2013 and identifies several comprehensive and targeted treatment models with evidence of clear benefits.
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Maternal infection and immune involvement in autism.
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A review of research trends in physiological abnormalities in autism spectrum disorders: immune dysregulation, inflammation, oxidative stress, mitochondrial dysfunction and environmental toxicant exposures.
TL;DR: Evaluation of trends between the four major areas and the four comparison areas demonstrated that the largest relative growth was in immune dysregulation/inflammation, oxidative stress, toxicant exposures, genetics and neuroimaging.
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Alterations of the intestinal barrier in patients with autism spectrum disorders and in their first-degree relatives.
Laura de Magistris,Valeria Familiari,Antonio Pascotto,Anna Sapone,Alessandro Frolli,Patrizia Iardino,Maria Cartenì,Mario De Rosa,Ruggiero Francavilla,Gabriele Riegler,Roberto Militerni,Carmela Bravaccio +11 more
TL;DR: It is indicated that measuring IPT could help to identify a subgroup of patients with autism who could benefit from a gluten-free diet and indicate the presence of an intestinal (tight-junction linked) hereditary factor in the families of subjects with autism.
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Gastrointestinal microbiota in children with autism in Slovakia
Aleksandra Tomova,Veronika Husarova,Silvia Lakatosova,Jan Bakos,Barbora Vlková,Katarina Babinska,Daniela Ostatníková +6 more
TL;DR: This pilot study suggests the role of gut microbiota in autism as a part of the "gut-brain" axis and it is a basis for further investigation of the combined effect of microbial, genetic, and hormonal changes for development and clinical manifestation of autism.
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