Evaluation, Diagnosis, and Treatment of Gastrointestinal Disorders in Individuals With ASDs: A Consensus Report
Timothy Buie,Daniel B. Campbell,George J. Fuchs,Glenn T. Furuta,Glenn T. Furuta,Joseph Levy,Judy VandeWater,Agnes H. Whitaker,Dan Atkins,Dan Atkins,Margaret L. Bauman,Arthur L. Beaudet,Edward G. Carr,Michael D. Gershon,Susan L. Hyman,Pipop Jirapinyo,Harumi Jyonouchi,Koorosh Kooros,Rafail I. Kushak,Pat Levitt,Susan E. Levy,Jeffery D. Lewis,Katherine F. Murray,Marvin R. Natowicz,Aderbal Sabra,Barry K. Wershil,Sharon C. Weston,Lonnie K. Zeltzer,Harland S. Winter +28 more
Reads0
Chats0
TLDR
The consensus expert opinion of the panel was that individuals with ASDs deserve the same thoroughness and standard of care in the diagnostic workup and treatment of gastrointestinal concerns as should occur for patients without ASDs.Abstract:
Autism spectrum disorders (ASDs) are common and clinically heterogeneous neurodevelopmental disorders. Gastrointestinal disorders and associated symptoms are commonly reported in individuals with ASDs, but key issues such as the prevalence and best treatment of these conditions are incompletely understood. A central difficulty in recognizing and characterizing gastrointestinal dysfunction with ASDs is the communication difficulties experienced by many affected individuals. A multidisciplinary panel reviewed the medical literature with the aim of generating evidence-based recommendations for diagnostic evaluation and management of gastrointestinal problems in this patient population. The panel concluded that evidence-based recommendations are not yet available. The consensus expert opinion of the panel was that individuals with ASDs deserve the same thoroughness and standard of care in the diagnostic workup and treatment of gastrointestinal concerns as should occur for patients without ASDs. Care providers should be aware that problem behavior in patients with ASDs may be the primary or sole symptom of the underlying medical condition, including some gastrointestinal disorders. For these patients, integration of behavioral and medical care may be most beneficial. Priorities for future research are identified to advance our understanding and management of gastrointestinal disorders in persons with ASDs.read more
Citations
More filters
Journal ArticleDOI
Urinary p-cresol is elevated in small children with severe autism spectrum disorder
Laura Altieri,Cristina Neri,Roberto Sacco,Paolo Curatolo,Arianna Benvenuto,Filippo Muratori,Elisa Santocchi,Carmela Bravaccio,C. Lenti,Monica Saccani,Roberto Rigardetto,Marina Gandione,Andrea Urbani,Antonio M. Persico +13 more
TL;DR: Urinary p-cresol was significantly elevated in autistic children smaller than 8 years of age and typically females and more severely affected regardless of sex, and elevated urinary cotinine measurements excluded smoking-related hydrocarbon contaminations as contributors to these differences.
Journal ArticleDOI
Clinical Spectrum of Food Allergies: a Comprehensive Review
TL;DR: This review focuses on the clinical spectrum and manifestations of various forms of food allergies, including atopic eczema, infantile colic, and gastroesophageal reflux, which are frequently associated with food hypersensitivity and respond to dietary elimination.
Journal ArticleDOI
Comprehensive nutritional and dietary intervention for autism spectrum disorder—a randomized, controlled 12-month trial
James B. Adams,Tapan Audhya,Elizabeth Geis,Eva Gehn,Valeria Fimbres,Elena L. Pollard,Jessica Mitchell,Julie Ingram,Robert Hellmers,Dana Laake,Julie S. Matthews,Kefeng Li,Jane C. Naviaux,Robert K. Naviaux,Rebecca L. Adams,Devon M. Coleman,David Quig +16 more
TL;DR: It is suggested that a comprehensive nutritional and dietary intervention is effective at improving nutritional status, non-verbal IQ, autism symptoms, and other symptoms in most individuals with ASD.
Journal ArticleDOI
Redox metabolism abnormalities in autistic children associated with mitochondrial disease
Richard E. Frye,R DeLaTorre,H B Taylor,John Slattery,John Slattery,S Melnyk,S Melnyk,Nupur Chowdhury,S J James,S J James +9 more
TL;DR: It is suggested that ASD/MD children with a more chronic oxidized microenvironment have better development and different subgroups of children with ASD have different redox abnormalities, which may arise from different sources.
Journal ArticleDOI
Gastrointestinal symptoms and autism spectrum disorder: links and risks – a possible new overlap syndrome
TL;DR: Practical use of the concept of an overlap syndrome of ASD and GI disorders may help in identifying those children with ASD who suffer from an alimentary tract disease and shorten the time to diagnosis and treatment commencement, and thereby alleviate both GI and ASD symptoms through reducing pain, stress, or discomfort.
References
More filters
Journal ArticleDOI
GRADE: an emerging consensus on rating quality of evidence and strength of recommendations
Gordon H. Guyatt,Andrew D Oxman,Gunn Elisabeth Vist,Regina Kunz,Yngve Falck-Ytter,Pablo Alonso-Coello,Holger J. Schünemann +6 more
TL;DR: The advantages of the GRADE system are explored, which is increasingly being adopted by organisations worldwide and which is often praised for its high level of consistency.
Journal ArticleDOI
Grading quality of evidence and strength of recommendations.
David C. Atkins,Dana Best,Peter A. Briss,Martin P Eccles,Yngve Falck-Ytter,Signe Flottorp,Gordon H. Guyatt,Robin Harbour,Margaret C Haugh,David Henry,Suzanne Hill,Roman Jaeschke,Gillian Leng,Alessandro Liberati,Nicola Magrini,James Mason,Philippa Middleton,Jacek Mrukowicz,Dianne L. O'Connell,Andrew D Oxman,Bob Phillips,Holger J. Schünemann,Tessa Tan-Torres Edejer,H. Varonen,Gunn Elisabeth Vist,John W Williams,Stephanie Zaza +26 more
TL;DR: A system for grading the quality of evidence and the strength of recommendations that can be applied across a wide range of interventions and contexts is developed, and a summary of the approach from the perspective of a guideline user is presented.
Journal ArticleDOI
Prevalence of overweight and obesity among us children, adolescents, and adults, 1999-2002
Allison A. Hedley,Cynthia L. Ogden,Clifford L. Johnson,Margaret D. Carroll,Lester R. Curtin,Katherine M. Flegal +5 more
TL;DR: The NHANES results indicate continuing disparities by sex and between racial/ethnic groups in the prevalence of overweight and obesity among adults and overweight among children, using the most recent national data of height and weight measurements.
Journal ArticleDOI
Ileal-lymphoid-nodular hyperplasia, non-specific colitis, and pervasive developmental disorder in children
Andrew J. Wakefield,S. H. Murch,A Anthony,J Linnell,D M Casson,M Malik,M Berelowitz,Ap Dhillon,Mike Thomson,Peter Harvey,A Valentine,S Davies,J A Walker-Smith +12 more
TL;DR: In this paper, the authors investigated a consecutive series of children with chronic enterocolitis and regressive developmental disorder, and identified associated gastrointestinal disease and developmental regression in a group of previously normal children, which was generally associated in time with possible environmental triggers.
Journal ArticleDOI
Neuroglial activation and neuroinflammation in the brain of patients with autism
Diana L. Vargas,Caterina Nascimbene,Caterina Nascimbene,Chitra Krishnan,Andrew W. Zimmerman,Andrew W. Zimmerman,Carlos A. Pardo +6 more
TL;DR: It is indicated that innate neuroimmune reactions play a pathogenic role in an undefined proportion of autistic patients, suggesting that future therapies might involve modifying neuroglial responses in the brain.