Evidence for gastrointestinal infection of SARS-CoV-2
Fei Xiao,Meiwen Tang,Xiaobin Zheng,Chunna Li,Jianzhong He,Zhongsi Hong,Siwen Huang,Zhenyi Zhang,Xianqi Lin,Zhaoxiong Fang,Renxu Lai,Shoudeng Chen,Jing Liu,Jin Huang,Jinyu Xia,Zhonghe Li,Guanmin Jiang,Ye Liu,Xiaofeng Li,Hong Shan +19 more
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TLDR
Evidence is provided for gastrointestinal infection of SARS-CoV-2, highlighting its potential fecal-oral transmission route and positive immunofluorescent staining of viral host receptor ACE2 and viral nucleocapsid protein in a case of Sars-Co V-2 infection.Abstract:
The new coronavirus (SARS-CoV-2) outbreak originating from Wuhan, China, poses a threat to global health. While it’s evident that the virus invades respiratory tract and transmits from human to human through airway, other viral tropisms and transmission routes remain unknown. We tested viral RNA in stool from 73 SARS-CoV-2-infected hospitalized patients using rRT-PCR. 53.42% of the patients tested positive in stool. 23.29% of the patients remained positive in feces even after the viral RNA decreased to undetectable level in respiratory tract. The viral RNA was also detected in gastrointestinal tissues. Furthermore, gastric, duodenal and rectal epithelia showed positive immunofluorescent staining of viral host receptor ACE2 and viral nucleocapsid protein in a case of SARS-CoV-2 infection. Our results provide evidence for gastrointestinal infection of SARS-CoV-2, highlighting its potential fecal-oral transmission route.read more
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SARS-CoV-2 RNA in wastewater anticipated COVID-19 occurrence in a low prevalence area.
TL;DR: The detection of SARS-CoV-2 in wastewater in early stages of the spread of COVID-19 highlights the relevance of this strategy as an early indicator of the infection within a specific population.
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Diarrhea During COVID-19 Infection: Pathogenesis, Epidemiology, Prevention, and Management.
Ferdinando D'Amico,Ferdinando D'Amico,Daniel C. Baumgart,Silvio Danese,Laurent Peyrin-Biroulet +4 more
TL;DR: Investigating the epidemiology, clinical presentation, molecular mechanisms, management, and prevention of SARS-CoV-2 associated diarrhea indicates possible fecal oral transmission, indicating the need for a rapid and effective modification of the screening and diagnostic algorithms.
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Coronavirus in water environments: Occurrence, persistence and concentration methods - A scoping review.
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The Potential Impact of Zinc Supplementation on COVID-19 Pathogenesis.
TL;DR: The potential of zinc as preventive and therapeutic agent alone or in combination with other strategies, as zinc meets all the above described criteria is discussed.
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Potential spreading risks and disinfection challenges of medical wastewater by the presence of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) viral RNA in septic tanks of Fangcang Hospital.
Dayi Zhang,Haibo Ling,Xia Huang,Jing Li,Weiwei Li,Chuan Yi,Ting Zhang,Yongzhong Jiang,Yuning He,Songqiang Deng,Xian Zhang,Xinzi Wang,Yi Liu,Guanghe Li,Jiuhui Qu,Jiuhui Qu +15 more
TL;DR: The effluents showed negative results for SARS-CoV-2 viral RNA when overdosed with sodium hypochlorite but had high a level of disinfection by-product residuals, possessing significant ecological risks.
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