Evidence of the COVID-19 Virus Targeting the CNS: Tissue Distribution, Host–Virus Interaction, and Proposed Neurotropic Mechanisms
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TLDR
The density of the expression levels of ACE2 in the CNS, the host–virus interaction and relate it to the pathogenesis and complications seen in the recent cases resulting from the COVID-19 outbreak are investigated.Abstract:
The recent outbreak of coronavirus infectious disease 2019 (COVID-19) has gripped the world with apprehension and has evoked a scare of epic proportion regarding its potential to spread and infect ...read more
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Heralding Healthcare Professionals: Recognition of Neurological Deficits in COVID-19.
TL;DR: It is of paramount importance that the scientific community alerts the healthcare professionals of the pieces of evidence that can herald them on the covert neurological deficits in progress in COVID-19 to reduce the morbidity and mortality of patients with CO VID-19.
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Infectious diseases, autoantibodies, and autoimmunity.
Douglas F Johnson,Wei Jiang +1 more
TL;DR: Infections are known to trigger flares of autoimmune diseases in humans and serve as an inciting cause of autoimmunity in animals as mentioned in this paper , however, previous thought mainly through antigen mimicry.
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Delayed onset of fatal encephalitis in a COVID-19 positive patient.
Luca Zanin,Giorgio Saraceno,Giulia Renisi,Liana Signorini,Luigi Battaglia,Marco Ferrara,Francesco Antonio Rasulo,Pier Paolo Panciani,Marco Maria Fontanella +8 more
TL;DR: The SARS-nCoV-2019 epidemic has spread since December 2019, quickly gaining worldwide attention as mentioned in this paper. Symptoms consist of fever, cough and breathing difficulties, and an increasing number of stu...
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Environmental pollutant exposure can exacerbate COVID-19 neurologic symptoms.
TL;DR: The hypothesis that the neurologic symptoms in COVID-19 may be exacerbated through a neuroinflammatory mechanism that is promoted by environmental pollutant exposure is explored.
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Evaluating the evidence for direct central nervous system invasion in patients infected with the nCOVID-19 virus
Patrick Lekgwara,Adrian Kelly +1 more
TL;DR: A PubMed review of the literature was performed to specifically assess the evidence for the direct CNS invasion by the nCOVID-19 virus to explain the cerebral oedema and encephalitis, that does occur, and bring Neurosurgeons into the management of these patients by for example directed intra-cranial pressure management post insertion of an intra-Cranial Pressure monitor.
References
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Daniel Wrapp,Nianshuang Wang,Kizzmekia S. Corbett,Jory A. Goldsmith,Ching-Lin Hsieh,Olubukola M. Abiona,Barney S. Graham,Jason S. McLellan +7 more
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The neuroinvasive potential of SARS-CoV2 may play a role in the respiratory failure of COVID-19 patients
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Neurological Manifestations of Hospitalized Patients with COVID-19 in Wuhan, China: a retrospective case series study
Ling Mao,Mengdie Wang,Shanghai Chen,Quan-Wei He,Jiang Chang,Candong Hong,Yifan Zhou,David Z. Wang,Yanan Li,Huijuan Jin,Bo Hu +10 more
TL;DR: In this paper, the neurological manifestations of patients with coronavirus disease 2019 (COVID-19) were studied in three categories: central nervous system (CNS) symptoms or diseases (headache, dizziness, impaired consciousness, ataxia, acute cerebrovascular disease, and epilepsy), peripheral nervous system symptoms (hypogeusia, hyposmia, hypopsia, and neuralgia), and skeletal muscular symptoms.
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