Evidence of the COVID-19 Virus Targeting the CNS: Tissue Distribution, Host–Virus Interaction, and Proposed Neurotropic Mechanisms
Reads0
Chats0
TLDR
The density of the expression levels of ACE2 in the CNS, the host–virus interaction and relate it to the pathogenesis and complications seen in the recent cases resulting from the COVID-19 outbreak are investigated.Abstract:
The recent outbreak of coronavirus infectious disease 2019 (COVID-19) has gripped the world with apprehension and has evoked a scare of epic proportion regarding its potential to spread and infect ...read more
Citations
More filters
Journal ArticleDOI
Pathogenesis of Olfactory Disorders in COVID-19
TL;DR: The current understanding of the pathogenesis of smell impairment in the course of COVID-19 appears to be mainly due to sensorineural damage, with infection of the olfactory epithelium support cells via the ACE1 receptor and disruption of the OE caused by immense inflammatory reaction.
Journal ArticleDOI
Chemosensory Systems in COVID-19: Evolution of Scientific Research.
Sheila Veronese,Andrea Sbarbati +1 more
TL;DR: In this paper, a careful review of the literature was conducted to understand if it is clearer which people present chemosensory symptoms and if these are related to the severity of the disease.
Journal ArticleDOI
Autonomic dysfunction detection by an automatic pupillometer as a non-invasive test in patients recovered from COVID-19.
Mine Karahan,Atılım Armağan Demirtaş,Leyla Hazar,Seyfettin Erdem,Sedat Ava,Mehmet Dursun,Uğur Keklikçi +6 more
TL;DR: In this paper, the authors measured pupil responses using a pupillometry system to recognize dysfunctions in the autonomic nervous system with changes in dynamic and static pupillary responses in patients who recovered from coronavirus disease-2019.
Journal ArticleDOI
A comprehensive review of COVID-19 biology, diagnostics, therapeutics, and disease impacting the central nervous system.
Anastasia Williams,Heather Branscome,Heather Branscome,Pooja Khatkar,Gifty A. Mensah,Sarah Al Sharif,Daniel O. Pinto,Daniel O. Pinto,Catherine DeMarino,Fatah Kashanchi +9 more
TL;DR: A comprehensive review of the neurological implications of SARS-CoV-2 is presented in this paper, where the authors provide a comprehensive summary of the research done on SARS CoV2 pathology, diagnosis, therapeutics, and vaccines up to May 5.
Journal ArticleDOI
COVID-19 associated nervous system manifestations.
TL;DR: In this article, a review of observed neurological manifestations associated with COVID-19 is provided, which indicate that SARS-CoV-2 can be considered as an opportunistic pathogen of the brain.
References
More filters
Journal ArticleDOI
Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation.
Daniel Wrapp,Nianshuang Wang,Kizzmekia S. Corbett,Jory A. Goldsmith,Ching-Lin Hsieh,Olubukola M. Abiona,Barney S. Graham,Jason S. McLellan +7 more
TL;DR: The authors show that this protein binds at least 10 times more tightly than the corresponding spike protein of severe acute respiratory syndrome (SARS)–CoV to their common host cell receptor, and test several published SARS-CoV RBD-specific monoclonal antibodies found that they do not have appreciable binding to 2019-nCoV S, suggesting that antibody cross-reactivity may be limited between the two RBDs.
Journal ArticleDOI
The neuroinvasive potential of SARS-CoV2 may play a role in the respiratory failure of COVID-19 patients
TL;DR: It remains to make clear whether the potential invasion of SARS‐CoV2 is partially responsible for the acute respiratory failure of patients with COVID‐19, which emerged in December 2019 in Wuhan, China and rapidly spreads around the world.
Journal ArticleDOI
Severe acute respiratory syndrome coronavirus infection causes neuronal death in the absence of encephalitis in mice transgenic for human ACE2.
TL;DR: The results show that neurons are a highly susceptible target for SARS-CoV and that only the absence of the host cell receptor prevents severe murine brain disease.
Posted ContentDOI
Neurological Manifestations of Hospitalized Patients with COVID-19 in Wuhan, China: a retrospective case series study
Ling Mao,Mengdie Wang,Shanghai Chen,Quan-Wei He,Jiang Chang,Candong Hong,Yifan Zhou,David Z. Wang,Yanan Li,Huijuan Jin,Bo Hu +10 more
TL;DR: In this paper, the neurological manifestations of patients with coronavirus disease 2019 (COVID-19) were studied in three categories: central nervous system (CNS) symptoms or diseases (headache, dizziness, impaired consciousness, ataxia, acute cerebrovascular disease, and epilepsy), peripheral nervous system symptoms (hypogeusia, hyposmia, hypopsia, and neuralgia), and skeletal muscular symptoms.
Journal ArticleDOI
TISSUES 2.0: an integrative web resource on mammalian tissue expression
TL;DR: A database of gene–tissue associations in human, mouse, rat and pig by integrating multiple sources of evidence: transcriptomics covering all four species and proteomics (human only), manually curated and mined from the scientific literature is developed.
Related Papers (5)
Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China
Chaolin Huang,Yeming Wang,Xingwang Li,Lili Ren,Jianping Zhao,Yi Hu,Li Zhang,Guohui Fan,Jiuyang Xu,Xiaoying Gu,Zhenshun Cheng,Ting Yu,Jia'an Xia,Yuan Wei,Wenjuan Wu,Xuelei Xie,Wen Yin,Li Hui,Min Liu,Yan Xiao,Hong Gao,Li Guo,Jungang Xie,Guang-Fa Wang,Rongmeng Jiang,Zhancheng Gao,Qi Jin,Jianwei Wang,Bin Cao +28 more
Clinical Characteristics of Coronavirus Disease 2019 in China.
Wei-jie Guan,Zhengyi Ni,Yu Hu,Wenhua Liang,Chun-Quan Ou,Jianxing He,Lei Liu,Hong Shan,Chunliang Lei,David S.C. Hui,Bin Du,Lanjuan Li,Guang Zeng,Kowk-Yung Yuen,Ruchong Chen,Chun-Li Tang,Tao Wang,Ping-Yan Chen,Jie Xiang,Shiyue Li,Jinlin Wang,Zi-jing Liang,Yi-xiang Peng,Li Wei,Yong Liu,Ya-hua Hu,Peng Peng,Jian-ming Wang,Ji-yang Liu,Zhong Chen,Gang Li,Zhi-jian Zheng,Shao-qin Qiu,Jie Luo,Chang-jiang Ye,Shao-yong Zhu,Nanshan Zhong +36 more