scispace - formally typeset
Open AccessJournal ArticleDOI

Evidence of the COVID-19 Virus Targeting the CNS: Tissue Distribution, Host–Virus Interaction, and Proposed Neurotropic Mechanisms

Abdul Mannan Baig, +3 more
- 13 Mar 2020 - 
- Vol. 11, Iss: 7, pp 995-998
Reads0
Chats0
TLDR
The density of the expression levels of ACE2 in the CNS, the host–virus interaction and relate it to the pathogenesis and complications seen in the recent cases resulting from the COVID-19 outbreak are investigated.
Abstract: 
The recent outbreak of coronavirus infectious disease 2019 (COVID-19) has gripped the world with apprehension and has evoked a scare of epic proportion regarding its potential to spread and infect ...

read more

Content maybe subject to copyright    Report

Citations
More filters
Journal ArticleDOI

Cerebral Microbleeds Assessment and Quantification in COVID-19 Patients With Neurological Manifestations

Angela Napolitano, +10 more
- 23 May 2022 - 
TL;DR: CMBs are a frequent imaging finding in hospitalized patients with COVID-19 with neurological manifestations and seem to be related to pro-inflammatory status.
Journal ArticleDOI

Human Brain Microvascular Endothelial Cells Exposure to SARS-CoV-2 Leads to Inflammatory Activation through NF-κB Non-Canonical Pathway and Mitochondrial Remodeling

Carolline Soares Motta, +17 more
- 01 Mar 2023 - 
TL;DR: In this article , the authors described the cellular and molecular effects of the human brain microvascular endothelial cells (HBMECs) in vitro exposure by SARS-CoV-2 to understand the underlying mechanisms of viral transmigration through the blood-brain barrier.
Journal ArticleDOI

Role of SARS-CoV-2 in Modifying Neurodegenerative Processes in Parkinson’s Disease: A Narrative Review

Jeremy M Morowitz, +3 more
- 22 Apr 2022 - 
TL;DR: Under certain pathological circumstances, in vulnerable persons-with-Parkinson’s disease (PwP), SARS-CoV-2 acts as a neurodegenerative enhancer to potentially support the development or progression of PD and its related motor and non-motor symptoms.
Journal ArticleDOI

Neuropathogenesis in COVID-19.

Marcos Altable, +1 more
- 01 Nov 2020 - 
TL;DR: Understanding CNS involvement in the disease is especially challenging and current theories of pathogenesis include direct neuroinvasion, crossing of the blood–brain barrier by the virus, and a nicotinic hypothesis.
Posted ContentDOI

Neurological Complications of Pandemic COVID-19: What Have We Got So Far?

Isabelle Pastor Bandeira, +4 more
TL;DR: The possibility by which SARS-CoV-2 may affect the olfactive system of patients, either directly or indirectly, is discussed, as well as several CNS related features referred by several patients at the beginning of the disease.
References
More filters
Journal ArticleDOI

Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation.

Daniel Wrapp, +7 more
- 13 Mar 2020 - 
TL;DR: The authors show that this protein binds at least 10 times more tightly than the corresponding spike protein of severe acute respiratory syndrome (SARS)–CoV to their common host cell receptor, and test several published SARS-CoV RBD-specific monoclonal antibodies found that they do not have appreciable binding to 2019-nCoV S, suggesting that antibody cross-reactivity may be limited between the two RBDs.
Journal ArticleDOI

The neuroinvasive potential of SARS-CoV2 may play a role in the respiratory failure of COVID-19 patients

Yan-Chao Li, +2 more
- 27 Feb 2020 - 
TL;DR: It remains to make clear whether the potential invasion of SARS‐CoV2 is partially responsible for the acute respiratory failure of patients with COVID‐19, which emerged in December 2019 in Wuhan, China and rapidly spreads around the world.
Journal ArticleDOI

Severe acute respiratory syndrome coronavirus infection causes neuronal death in the absence of encephalitis in mice transgenic for human ACE2.

Jason Netland, +4 more
- 01 Aug 2008 - 
TL;DR: The results show that neurons are a highly susceptible target for SARS-CoV and that only the absence of the host cell receptor prevents severe murine brain disease.
Posted ContentDOI

Neurological Manifestations of Hospitalized Patients with COVID-19 in Wuhan, China: a retrospective case series study

Ling Mao, +10 more
- 25 Feb 2020 - 
TL;DR: In this paper, the neurological manifestations of patients with coronavirus disease 2019 (COVID-19) were studied in three categories: central nervous system (CNS) symptoms or diseases (headache, dizziness, impaired consciousness, ataxia, acute cerebrovascular disease, and epilepsy), peripheral nervous system symptoms (hypogeusia, hyposmia, hypopsia, and neuralgia), and skeletal muscular symptoms.
Journal ArticleDOI

TISSUES 2.0: an integrative web resource on mammalian tissue expression

Oana Palasca, +4 more
- 01 Jan 2018 - 
TL;DR: A database of gene–tissue associations in human, mouse, rat and pig by integrating multiple sources of evidence: transcriptomics covering all four species and proteomics (human only), manually curated and mined from the scientific literature is developed.
Related Papers (5)

Neurologic Manifestations of Hospitalized Patients With Coronavirus Disease 2019 in Wuhan, China.

Ling Mao, +12 more
- 01 Jan 2020 - 

Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China

Chaolin Huang, +28 more
- 24 Jan 2020 - 

Clinical Characteristics of Coronavirus Disease 2019 in China.

Wei-jie Guan, +36 more
- 28 Feb 2020 - 

SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor

Markus Hoffmann, +13 more
- 16 Apr 2020 - 

Clinical Characteristics of 138 Hospitalized Patients With 2019 Novel Coronavirus-Infected Pneumonia in Wuhan, China.

Dawei Wang, +13 more
- 17 Mar 2020 - 
Trending Questions (1)
Where does the ICAM interaction with CVA21 virus occur?

The provided paper does not mention anything about the ICAM interaction with the CVA21 virus. The paper is about the evidence of the COVID-19 virus targeting the CNS.

See answers from 5 other papers