Evidence of the COVID-19 Virus Targeting the CNS: Tissue Distribution, Host–Virus Interaction, and Proposed Neurotropic Mechanisms
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TLDR
The density of the expression levels of ACE2 in the CNS, the host–virus interaction and relate it to the pathogenesis and complications seen in the recent cases resulting from the COVID-19 outbreak are investigated.Abstract:
The recent outbreak of coronavirus infectious disease 2019 (COVID-19) has gripped the world with apprehension and has evoked a scare of epic proportion regarding its potential to spread and infect ...read more
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Associations of Dynapenic Obesity and Sarcopenic Obesity with the Risk of Complications in COVID-19
Laura Pérez-Campos Mayoral,Carlos Alberto Matias-Cervantes,Eduardo Pérez-Campos,Carlos Romero Díaz,Luis Ángel Laguna Barrios,María del Socorro Pina Canseco,Margarito Martínez Cruz,Eduardo Pérez-Campos Mayoral,Carlos Josué Solórzano Mata,Francisco Javier Rodal Canales,Hector Martínez Ruíz,María Teresa Hernández-Huerta +11 more
TL;DR: The presence of dynapenic obesity or sarcopenic obesity could be related to a poor prognosis in COVID-19 patients and skeletal muscle regulates the expression of inflammatory cytokines and supports metabolic stress in pulmonary disease.
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Smell and taste abnormalities: early clinical biomarkers for isolating the positive cases in COVID-19 pandemic
TL;DR: This review article focuses on the smell and taste abnormalities among COVID-19 patient which will surely increase the awareness among the front liner clinicians and help them for early diagnosis of the patient and their management.
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Bibliometric Analysis of the100 Highly-cited Articles about COVID-19
Ahmadreza Afshar,Ali Tabrizi +1 more
TL;DR: This study by no means negate high quality important articles that have been published recently and had not enough time to increase their citations yet, as findings are rapidly changing and subject to selection bias.
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The involvement of autophagy in the maintenance of endothelial homeostasis: The role of mitochondria.
TL;DR: In this article, the importance of mitochondria, endoplasmic reticulum and degradation mechanisms in vascular endothelial functions are summarized, and current knowledge related to the development of cardiovascular disorders and the importance in mitochondria and other degradation mechanisms is discussed.
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Neurological complications in COVID-19 - a diagnostic challenge.
TL;DR: In this article, the authors present the case of a patient who developed headaches, motor deficit and dysphasia after respiratory COVID-19, and showed heterogeneous central nervous system lesions (multiple subarachnoid hemorrhages and two ischemic strokes).
References
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Journal ArticleDOI
Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation.
Daniel Wrapp,Nianshuang Wang,Kizzmekia S. Corbett,Jory A. Goldsmith,Ching-Lin Hsieh,Olubukola M. Abiona,Barney S. Graham,Jason S. McLellan +7 more
TL;DR: The authors show that this protein binds at least 10 times more tightly than the corresponding spike protein of severe acute respiratory syndrome (SARS)–CoV to their common host cell receptor, and test several published SARS-CoV RBD-specific monoclonal antibodies found that they do not have appreciable binding to 2019-nCoV S, suggesting that antibody cross-reactivity may be limited between the two RBDs.
Journal ArticleDOI
The neuroinvasive potential of SARS-CoV2 may play a role in the respiratory failure of COVID-19 patients
TL;DR: It remains to make clear whether the potential invasion of SARS‐CoV2 is partially responsible for the acute respiratory failure of patients with COVID‐19, which emerged in December 2019 in Wuhan, China and rapidly spreads around the world.
Journal ArticleDOI
Severe acute respiratory syndrome coronavirus infection causes neuronal death in the absence of encephalitis in mice transgenic for human ACE2.
TL;DR: The results show that neurons are a highly susceptible target for SARS-CoV and that only the absence of the host cell receptor prevents severe murine brain disease.
Posted ContentDOI
Neurological Manifestations of Hospitalized Patients with COVID-19 in Wuhan, China: a retrospective case series study
Ling Mao,Mengdie Wang,Shanghai Chen,Quan-Wei He,Jiang Chang,Candong Hong,Yifan Zhou,David Z. Wang,Yanan Li,Huijuan Jin,Bo Hu +10 more
TL;DR: In this paper, the neurological manifestations of patients with coronavirus disease 2019 (COVID-19) were studied in three categories: central nervous system (CNS) symptoms or diseases (headache, dizziness, impaired consciousness, ataxia, acute cerebrovascular disease, and epilepsy), peripheral nervous system symptoms (hypogeusia, hyposmia, hypopsia, and neuralgia), and skeletal muscular symptoms.
Journal ArticleDOI
TISSUES 2.0: an integrative web resource on mammalian tissue expression
TL;DR: A database of gene–tissue associations in human, mouse, rat and pig by integrating multiple sources of evidence: transcriptomics covering all four species and proteomics (human only), manually curated and mined from the scientific literature is developed.
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