Evidence of the COVID-19 Virus Targeting the CNS: Tissue Distribution, Host–Virus Interaction, and Proposed Neurotropic Mechanisms
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TLDR
The density of the expression levels of ACE2 in the CNS, the host–virus interaction and relate it to the pathogenesis and complications seen in the recent cases resulting from the COVID-19 outbreak are investigated.Abstract:
The recent outbreak of coronavirus infectious disease 2019 (COVID-19) has gripped the world with apprehension and has evoked a scare of epic proportion regarding its potential to spread and infect ...read more
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Journal ArticleDOI
Analysis of ACE2 Genetic Variability among Populations Highlights a Possible Link with COVID-19-Related Neurological Complications.
Claudia Strafella,Valerio Caputo,Andrea Termine,Shila Barati,Stefano Gambardella,Paola Borgiani,Carlo Caltagirone,Giuseppe Novelli,Emiliano Giardina,Raffaella Cascella,Raffaella Cascella +10 more
TL;DR: Investigation of the genetic variability of ACE2 in terms of single nucleotide variants, copy number variations, and expression quantitative loci revealed a high distribution of eQTL variants in different brain tissues, suggesting a possible link between ACE2 genetic variability and the neurological complications in patients with COVID-19.
Journal ArticleDOI
Acute and Post-Acute Neurological Complications of COVID-19.
TL;DR: In this article, a comprehensive literature review has summarized the most common neurological complications and reported neurological case studies associated with COVID-19, and neurological side effects associated with CoV-19 treatments, and proposed mechanisms that are involved in the pathogenesis of these neurological complications.
Journal ArticleDOI
COVID-19 Associated Ischemic Stroke and Hemorrhagic Stroke: Incidence, Potential Pathological Mechanism, and Management.
TL;DR: The markedly elevated D-dimer levels in patients with acute ischemic stroke suggests that SARS-CoV-2 infection may induce an inflammatory response and trigger a hypercoagulation state, thus leading to acute isChemic stroke.
Journal ArticleDOI
Covid-19-Induced Dysautonomia: A Menace of Sympathetic Storm.
Hayder M Al-Kuraishy,Ali I Al-Gareeb,Safaa Y. Qusti,Eida M. Alshammari,Gideon A. Gyebi,Gaber El-Saber Batiha +5 more
TL;DR: In this paper, the authors present an inclusive mini-review of SARS-CoV-2-induced dysautonomia and its associated complications, and conclude that the pathway involved in the development of DSN in Covid-19 is the sympathetic and cytokine storms together with activation of Renin-Angiotensin-System.
Journal ArticleDOI
The association of SARS-CoV-2 infection and acute disseminated encephalomyelitis without prominent clinical pulmonary symptoms.
TL;DR: A patient with acute disseminated encephalitis and COVID-19 died of status epilepticus and brain MRI of the patient indicated diffuse confluent white matter hyperintensities.
References
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Daniel Wrapp,Nianshuang Wang,Kizzmekia S. Corbett,Jory A. Goldsmith,Ching-Lin Hsieh,Olubukola M. Abiona,Barney S. Graham,Jason S. McLellan +7 more
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Neurological Manifestations of Hospitalized Patients with COVID-19 in Wuhan, China: a retrospective case series study
Ling Mao,Mengdie Wang,Shanghai Chen,Quan-Wei He,Jiang Chang,Candong Hong,Yifan Zhou,David Z. Wang,Yanan Li,Huijuan Jin,Bo Hu +10 more
TL;DR: In this paper, the neurological manifestations of patients with coronavirus disease 2019 (COVID-19) were studied in three categories: central nervous system (CNS) symptoms or diseases (headache, dizziness, impaired consciousness, ataxia, acute cerebrovascular disease, and epilepsy), peripheral nervous system symptoms (hypogeusia, hyposmia, hypopsia, and neuralgia), and skeletal muscular symptoms.
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