Evidence of the COVID-19 Virus Targeting the CNS: Tissue Distribution, Host–Virus Interaction, and Proposed Neurotropic Mechanisms
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TLDR
The density of the expression levels of ACE2 in the CNS, the host–virus interaction and relate it to the pathogenesis and complications seen in the recent cases resulting from the COVID-19 outbreak are investigated.Abstract:
The recent outbreak of coronavirus infectious disease 2019 (COVID-19) has gripped the world with apprehension and has evoked a scare of epic proportion regarding its potential to spread and infect ...read more
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[Epilepsy and COVID-19: patient management and optimization of antiepileptic therapy during pandemic]
TL;DR: The article discusses the main principles of epilepsy management during the COVID-19 pandemic: the need to comply with the regime; the importance of AED adherence, taking into account drug-drug interactions; switching patients to intravenous AED forms if necessary.
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Mild and moderate COVID-19 disease does not affect hearing function permanently: a cross-sectional study involving young and middle-aged healthcare givers.
TL;DR: In this article, the hearing thresholds of patients with mild and moderate COVID-19 disease were assessed using pure tone audiometry, and the differences between the HTs of none of the subgroups were statistically significant.
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Mental Health and COVID - 19: An Action Plan
TL;DR: A plan to easily frame the priorities of mental health area related to COVID-19 to be taken into consideration is provided which should be disseminated and that should be known by all health professionals and also by the major administrators of public health.
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Meta-Analysis of APP Expression Modulated by SARS-CoV-2 Infection via the ACE2 Receptor
TL;DR: The study results suggest that ACE2 could be downregulated by SARS-CoV-2, resulting in APP upregulation, and potentially exacerbating the onset and progression of AD.
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The contribution of whole-exome sequencing to intellectual disability diagnosis and knowledge of underlying molecular mechanisms: a systematic review and meta-analysis.
TL;DR: Investigation and estimate the rate of ID molecular diagnostic assessment by WES, quantify the contribution of DNMs to this rate, and biologically and functionally characterize the genes whose mutations were identified through WES support WES as an important approach to the molecular diagnosis of ID.
References
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The neuroinvasive potential of SARS-CoV2 may play a role in the respiratory failure of COVID-19 patients
TL;DR: It remains to make clear whether the potential invasion of SARS‐CoV2 is partially responsible for the acute respiratory failure of patients with COVID‐19, which emerged in December 2019 in Wuhan, China and rapidly spreads around the world.
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Neurological Manifestations of Hospitalized Patients with COVID-19 in Wuhan, China: a retrospective case series study
Ling Mao,Mengdie Wang,Shanghai Chen,Quan-Wei He,Jiang Chang,Candong Hong,Yifan Zhou,David Z. Wang,Yanan Li,Huijuan Jin,Bo Hu +10 more
TL;DR: In this paper, the neurological manifestations of patients with coronavirus disease 2019 (COVID-19) were studied in three categories: central nervous system (CNS) symptoms or diseases (headache, dizziness, impaired consciousness, ataxia, acute cerebrovascular disease, and epilepsy), peripheral nervous system symptoms (hypogeusia, hyposmia, hypopsia, and neuralgia), and skeletal muscular symptoms.
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