Evidence of the COVID-19 Virus Targeting the CNS: Tissue Distribution, Host–Virus Interaction, and Proposed Neurotropic Mechanisms
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TLDR
The density of the expression levels of ACE2 in the CNS, the host–virus interaction and relate it to the pathogenesis and complications seen in the recent cases resulting from the COVID-19 outbreak are investigated.Abstract:
The recent outbreak of coronavirus infectious disease 2019 (COVID-19) has gripped the world with apprehension and has evoked a scare of epic proportion regarding its potential to spread and infect ...read more
Citations
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Integrative analysis of miRNA and mRNA sequencing data reveals potential regulatory mechanisms of ACE2 and TMPRSS2.
Stepan Nersisyan,Stepan Nersisyan,Maxim Shkurnikov,Andrey Turchinovich,E N Knyazev,Alexander G. Tonevitsky +5 more
TL;DR: This work searched for putative ACE2 and TMPRSS2 expression regulation networks mediated by various miRNA isoforms (isomiR) across different human organs using publicly available paired miRNA/mRNA-sequencing data from The Cancer Genome Atlas (TCGA) project and identified several miRNA families targeting ACE 2 and TM PRSS2 genes in multiple tissues.
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Neurological complications in patients with SARS-CoV-2 infection: a systematic review.
Renato P. Munhoz,José Luiz Pedroso,Fábio A. Nascimento,Sérgio Monteiro de Almeida,Orlando Graziani Povoas Barsottini,Francisco Cardoso,Hélio A.G. Teive +6 more
TL;DR: Recognition of neurological manifestations of SARS-CoV-2 should be emphasized despite the obvious challenges faced by clinicians caring for critical patients who are often sedated and presenting other concurrent systemic complications.
Journal ArticleDOI
Neurological Aspects of SARS-CoV-2 Infection: Mechanisms and Manifestations
Parménides Guadarrama-Ortiz,José Alberto Choreño-Parra,Claudia Marisol Sánchez-Martínez,Francisco Javier Pacheco-Sánchez,Alberto Iván Rodríguez-Nava,Gabriela García-Quintero +5 more
TL;DR: The spectrum of neurological findings associated with COVID-19 is summarized, which include signs of peripheral neuropathy, myopathy, olfactory dysfunction, meningoencephalitis, Guillain-Barré syndrome, and neuropsychiatric disorders, and the mechanisms underlying such neurological sequela are analyzed.
Journal ArticleDOI
Safety of psychotropic medications in people with COVID-19: evidence review and practical recommendations.
Giovanni Ostuzzi,Davide Papola,Chiara Gastaldon,Georgios Schoretsanitis,F. Bertolini,Francesco Amaddeo,Alessandro Cuomo,Robin Emsley,Andrea Fagiolini,Giuseppe Imperadore,Taishiro Kishimoto,Giulia Michencigh,Michela Nosè,Marianna Purgato,Serdar M. Dursun,Brendon Stubbs,Brendon Stubbs,David Taylor,Graham Thornicroft,Philip B. Ward,Christoph Hiemke,Christoph U. Correll,Christoph U. Correll,Corrado Barbui +23 more
TL;DR: The present evidence-based recommendations will improve the quality of psychiatric care in people with COVID-19, allowing an appropriate management of the medical condition without worsening the psychiatric condition and vice versa.
Journal ArticleDOI
COVID-19: Review of a 21st Century Pandemic from Etiology to Neuro-psychiatric Implications.
Vicky Yamamoto,Joe Bolanos,John Fiallos,Susanne E. Strand,Kevin Morris,Sanam Shahrokhinia,Tim R. Cushing,Lawrence Hopp,Ambooj Tiwari,Robert J. Hariri,Rick Sokolov,Christopher Wheeler,Ajeet Kaushik,Ashraf Elsayegh,Dawn Eliashiv,Rebecca Hedrick,Behrouz Jafari,J. Patrick Johnson,Mehran Khorsandi,Nestor R Gonzalez,Guita Balakhani,Shouri Lahiri,Kazem Ghavidel,Marco Amaya,Harry Kloor,Namath Hussain,Edmund Huang,Jason Cormier,J. Wesson Ashford,Jeffrey C. Wang,Shadi Yaghobian,Payman Khorrami,Bahman Shamloo,Charles N Moon,Payam Shadi,Babak Kateb +35 more
TL;DR: A comprehensive review of SARS-CoV-2-induced disease, its mechanism of infection, diagnostics, therapeutics, and treatment strategies, while also focusing on less attended aspects by previous studies, including nutritional support, psychological, and rehabilitation of the pandemic and its management
References
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Neurological Manifestations of Hospitalized Patients with COVID-19 in Wuhan, China: a retrospective case series study
Ling Mao,Mengdie Wang,Shanghai Chen,Quan-Wei He,Jiang Chang,Candong Hong,Yifan Zhou,David Z. Wang,Yanan Li,Huijuan Jin,Bo Hu +10 more
TL;DR: In this paper, the neurological manifestations of patients with coronavirus disease 2019 (COVID-19) were studied in three categories: central nervous system (CNS) symptoms or diseases (headache, dizziness, impaired consciousness, ataxia, acute cerebrovascular disease, and epilepsy), peripheral nervous system symptoms (hypogeusia, hyposmia, hypopsia, and neuralgia), and skeletal muscular symptoms.
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