Evidence of the COVID-19 Virus Targeting the CNS: Tissue Distribution, Host–Virus Interaction, and Proposed Neurotropic Mechanisms
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TLDR
The density of the expression levels of ACE2 in the CNS, the host–virus interaction and relate it to the pathogenesis and complications seen in the recent cases resulting from the COVID-19 outbreak are investigated.Abstract:
The recent outbreak of coronavirus infectious disease 2019 (COVID-19) has gripped the world with apprehension and has evoked a scare of epic proportion regarding its potential to spread and infect ...read more
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Clinical features and cognitive sequelae in COVID-19: a retrospective study on N=152 patients.
Marina Manera,Elena Fiabane,Debora Pain,Edoardo Nicolò Aiello,Alice Radici,Marcella Ottonello,Mariacristina Padovani,Barbara Ann Wilson,Jessica Fish,Caterina Pistarini +9 more
TL;DR: In this article, the authors explored how post-infective cognitive status relates to clinical/treatment outcomes by controlling for premorbid/current risk factors for cognitive deficits, and found that ICU-admitted patients made more errors on the MMSE than those not admitted when partialling out risk factors and age.
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Pathophysiology and Imaging Findings of COVID-19 Infection: An Organ-system Based Review.
Kathleen M. Capaccione,Hao Yang,E West,H Patel,H Ma,S Patel,A Fruauff,G Loeb,A Maddocks,A Borowski,S Lala,P Nguyen,Angela Lignelli,Belinda D’Souza,Elise Desperito,Carrie Ruzal-Shapiro,Mary Salvatore +16 more
TL;DR: In this paper, the authors reviewed the pathophysiology and imaging characteristics of SARS-CoV-2 infection in organ systems throughout the body and explored commonalities, which is essential for the radiologist to recognize these findings in patients with COVID-19 infection.
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Neuroradiological features in COVID-19 patients: First evidence in a complex scenario.
TL;DR: Journal of Neuroradiology - Sous presse: Manuscrit accepte.
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Vasculature-on-a-chip platform with innate immunity enables identification of angiopoietin-1 derived peptide as a therapeutic for SARS-CoV-2 induced inflammation.
Rick Xing Ze Lu,Benjamin F.L. Lai,Naimeh Rafatian,Dakota Gustafson,Scott B. Campbell,Arinjay Banerjee,Robert A. Kozak,Karen L. Mossman,Samira Mubareka,Kathryn L. Howe,Jason E. Fish,Milica Radisic +11 more
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Neuropsychological, Medical, and Psychiatric Findings After Recovery From Acute COVID-19: A Cross-sectional Study
Stephen J. Ferrando,Rhea Dornbush,Sean Lynch,Sivan Shahar,Lidia Klepacz,Carol L. Karmen,Donald Chen,Stephen A. Lobo,Dania Lerman +8 more
TL;DR: In this paper , the authors describe neuropsychological, medical, psychiatric, and functional correlates of cognitive complaints experienced after recovery from acute SARS-CoV-2 infection, and show that extremely low test performance is associated with worse acute COVID-19 symptoms, depression, medical comorbidities, functional complaints, and subjective cognitive complaints.
References
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Neurological Manifestations of Hospitalized Patients with COVID-19 in Wuhan, China: a retrospective case series study
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TL;DR: In this paper, the neurological manifestations of patients with coronavirus disease 2019 (COVID-19) were studied in three categories: central nervous system (CNS) symptoms or diseases (headache, dizziness, impaired consciousness, ataxia, acute cerebrovascular disease, and epilepsy), peripheral nervous system symptoms (hypogeusia, hyposmia, hypopsia, and neuralgia), and skeletal muscular symptoms.
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