Evidence of the COVID-19 Virus Targeting the CNS: Tissue Distribution, Host–Virus Interaction, and Proposed Neurotropic Mechanisms
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TLDR
The density of the expression levels of ACE2 in the CNS, the host–virus interaction and relate it to the pathogenesis and complications seen in the recent cases resulting from the COVID-19 outbreak are investigated.Abstract:
The recent outbreak of coronavirus infectious disease 2019 (COVID-19) has gripped the world with apprehension and has evoked a scare of epic proportion regarding its potential to spread and infect ...read more
Citations
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Long COVID Neuropsychological Deficits After Severe, Moderate or Mild Infection
Philippe Voruz,Philippe Voruz,Gilles Allali,Gilles Allali,Benzakour L,Benzakour L,Nuber-Champier A,Marine Thomasson,Marine Thomasson,Jacot I,Jacot I,Jordan E. Pierce,Patrice H. Lalive,Patrice H. Lalive,Karl-Olof Lövblad,Karl-Olof Lövblad,Olivia Braillard,Matteo Coen,Matteo Coen,Jacques Serratrice,Jacques Serratrice,Jérôme Pugin,Jérôme Pugin,Radek Ptak,Radek Ptak,Idris Guessous,Idris Guessous,Basile Nicolas Landis,Basile Nicolas Landis,Frédéric Assal,Frédéric Assal,Julie Anne Peron,Julie Anne Peron +32 more
TL;DR: In this article, the authors found that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection can include long-term neuropsychological deficits, even in its mild or moderate respiratory forms.
Journal ArticleDOI
Potential Neurological Manifestations of COVID-19: A Narrative Review.
Joseph V. Pergolizzi,Robert B. Raffa,Robert B. Raffa,Giustino Varrassi,Peter Magnusson,Peter Magnusson,Jo Ann LeQuang,Antonella Paladini,Robert W. Taylor,Charles Wollmuth,Frank Breve,Maninder Chopra,Rohit Nalamasu,Paul J. Christo +13 more
TL;DR: A growing body of evidence is accumulating that COVID-19, particularly in severe cases, may have neurological consequences although respiratory symptoms nearly always develop prior to neurological ones.
Journal ArticleDOI
Neuropsychiatric manifestations of COVID-19, potential neurotropic mechanisms, and therapeutic interventions.
Ying Han,Kai Yuan,Zhe Wang,Wei-Jian Liu,Zheng-An Lu,Lin Liu,Le Shi,Wei Yan,Jun-Liang Yuan,Jia-Li Li,Jie Shi,Zhongchun Liu,Gaohua Wang,Thomas R. Kosten,Yanping Bao,Lin Lu,Lin Lu +16 more
TL;DR: In this paper, the authors summarize recent animal and human studies for neurotrophic properties of severe acute respiratory syndrome coronavirus (SARS-CoV-2) and elucidate potential neuropathogenic mechanisms involved in the viral invasion of the central nervous system as a cause for brain damage and neurological impairments.
Journal ArticleDOI
Neuroinvasion of SARS-CoV-2 may play a role in the breakdown of the respiratory center of the brain.
Jhilik Dey,Jhilik Dey,Tanjim Alam,Sreyashi Chandra,Sreyashi Chandra,Jalaj Gupta,Upasana Ray,Upasana Ray,Amit Kumar Srivastava,Amit Kumar Srivastava,Prem Prakash Tripathi,Prem Prakash Tripathi +11 more
TL;DR: How SARS‐CoV‐2 might infect the brain is discussed, especially toward the breakdown of the respiratory center in the brainstem, which could be responsible for the respiratory failure in many COVID‐19 patients.
Journal ArticleDOI
Is anosmia the price to pay in an immune-induced scorched-earth policy against COVID-19?
S.D. Le Bon,Mihaela Horoi +1 more
TL;DR: It is hypothesised that sudden loss of smell due to COVID-19 is the consequence of a protective host defence mechanism involving apoptosis of olfactory receptor neurons, which may orient research to investigate the risk of future neurodegenerative disease linked to persisting coronavirus in neurons.
References
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Posted ContentDOI
Neurological Manifestations of Hospitalized Patients with COVID-19 in Wuhan, China: a retrospective case series study
Ling Mao,Mengdie Wang,Shanghai Chen,Quan-Wei He,Jiang Chang,Candong Hong,Yifan Zhou,David Z. Wang,Yanan Li,Huijuan Jin,Bo Hu +10 more
TL;DR: In this paper, the neurological manifestations of patients with coronavirus disease 2019 (COVID-19) were studied in three categories: central nervous system (CNS) symptoms or diseases (headache, dizziness, impaired consciousness, ataxia, acute cerebrovascular disease, and epilepsy), peripheral nervous system symptoms (hypogeusia, hyposmia, hypopsia, and neuralgia), and skeletal muscular symptoms.
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