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Evidence of the COVID-19 Virus Targeting the CNS: Tissue Distribution, Host–Virus Interaction, and Proposed Neurotropic Mechanisms

Abdul Mannan Baig, +3 more
- 13 Mar 2020 - 
- Vol. 11, Iss: 7, pp 995-998
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TLDR
The density of the expression levels of ACE2 in the CNS, the host–virus interaction and relate it to the pathogenesis and complications seen in the recent cases resulting from the COVID-19 outbreak are investigated.
Abstract: 
The recent outbreak of coronavirus infectious disease 2019 (COVID-19) has gripped the world with apprehension and has evoked a scare of epic proportion regarding its potential to spread and infect ...

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Role of Systemic and Nasal Glucocorticoid Treatment in the Regulation of the Inflammatory Response in Patients with SARS-Cov-2 Infection.

Graciela Cárdenas, +7 more
- 01 Feb 2021 - 
TL;DR: The use of the intranasal route for glucocorticoid administration is proposed, which has been shown to effectively control the neuro-and peripheral-inflammatory response using low doses without generating unwanted side effects.
Journal ArticleDOI

Innovative Nanotechnology a Boon for Fight Against Pandemic COVID–19

Ibrahim Aminu Shehu, +10 more
TL;DR: In this paper, the authors highlighted the perspective contributions of nanotechnology in the war against the COVID-19 pandemic by searching for the combinations of the research keywords in the official scientific databases such as Science Direct, PubMed, and Google Scholar.
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Mesenchymal Stem Cells in the Treatment of New Coronavirus Pandemic: A Novel Promising Therapeutic Approach

Sara Razi, +11 more
- 27 Mar 2021 - 
TL;DR: MSC treatment may have the potential to end the high mortality rate of COVID-19 and it also limits the long-term inability of survivors, so it had better be tried for treating other pathogens worldwide.
Journal ArticleDOI

Research Progress on the Role of Microglia Membrane Proteins or Receptors in Neuroinflammation and Degeneration

Junfeng Zhao, +5 more
- 25 Feb 2022 - 
TL;DR: In this paper, several representative membrane proteins or receptors present on the surface of microglia are systematically reviewed and information about their structures, functions and specific roles in one or more neurological diseases are presented.
Journal ArticleDOI

Smell dysfunction in patients with COVID-19

A. R. Artemenko, +2 more
TL;DR: Scientists analyze scientific data on anosmia in COVID-19 based on the results of primary research using PubMed, Google Scholar, and eLIBRARY databases to determine the final clinical and pathophysiological significance of olfactory symptoms.
References
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Journal ArticleDOI

Cryo-EM structure of the 2019-nCoV spike in the prefusion conformation.

Daniel Wrapp, +7 more
- 13 Mar 2020 - 
TL;DR: The authors show that this protein binds at least 10 times more tightly than the corresponding spike protein of severe acute respiratory syndrome (SARS)–CoV to their common host cell receptor, and test several published SARS-CoV RBD-specific monoclonal antibodies found that they do not have appreciable binding to 2019-nCoV S, suggesting that antibody cross-reactivity may be limited between the two RBDs.
Journal ArticleDOI

The neuroinvasive potential of SARS-CoV2 may play a role in the respiratory failure of COVID-19 patients

Yan-Chao Li, +2 more
- 27 Feb 2020 - 
TL;DR: It remains to make clear whether the potential invasion of SARS‐CoV2 is partially responsible for the acute respiratory failure of patients with COVID‐19, which emerged in December 2019 in Wuhan, China and rapidly spreads around the world.
Journal ArticleDOI

Severe acute respiratory syndrome coronavirus infection causes neuronal death in the absence of encephalitis in mice transgenic for human ACE2.

Jason Netland, +4 more
- 01 Aug 2008 - 
TL;DR: The results show that neurons are a highly susceptible target for SARS-CoV and that only the absence of the host cell receptor prevents severe murine brain disease.
Posted ContentDOI

Neurological Manifestations of Hospitalized Patients with COVID-19 in Wuhan, China: a retrospective case series study

Ling Mao, +10 more
- 25 Feb 2020 - 
TL;DR: In this paper, the neurological manifestations of patients with coronavirus disease 2019 (COVID-19) were studied in three categories: central nervous system (CNS) symptoms or diseases (headache, dizziness, impaired consciousness, ataxia, acute cerebrovascular disease, and epilepsy), peripheral nervous system symptoms (hypogeusia, hyposmia, hypopsia, and neuralgia), and skeletal muscular symptoms.
Journal ArticleDOI

TISSUES 2.0: an integrative web resource on mammalian tissue expression

Oana Palasca, +4 more
- 01 Jan 2018 - 
TL;DR: A database of gene–tissue associations in human, mouse, rat and pig by integrating multiple sources of evidence: transcriptomics covering all four species and proteomics (human only), manually curated and mined from the scientific literature is developed.
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Trending Questions (1)
Where does the ICAM interaction with CVA21 virus occur?

The provided paper does not mention anything about the ICAM interaction with the CVA21 virus. The paper is about the evidence of the COVID-19 virus targeting the CNS.

See answers from 5 other papers