Journal ArticleDOI
Focus on genetic and epigenetic events of colorectal cancer pathogenesis: implications for molecular diagnosis
Federica Zoratto,Luigi Rossi,Monica Verrico,Anselmo Papa,Enrico Basso,Angelo Zullo,Luigi Tomao,Adriana Romiti,Giuseppe Lo Russo,Silverio Tomao +9 more
TLDR
This review summarizes the most investigated biomolecular pathways involved in CRC pathogenesis, their role as biomarkers for early CRC diagnosis and their possible use to stratify susceptible patients into appropriate screening or surveillance programs.Abstract:
Originally, colorectal cancer (CRC) tumorigenesis was understood as a multistep process that involved accumulation of tumor suppressor genes and oncogenes mutations, such as APC, TP53 and KRAS. However, this assumption proposed a relatively limited repertoire of genetic alterations. In the last decade, there have been major advances in knowledge of multiple molecular pathways involved in CRC pathogenesis, particularly regarding cytogenetic and epigenetic events. Microsatellite instability, chromosomal instability and CpG island methylator phenotype are the most analyzed cytogenetic changes, while DNA methylation, modifications in histone proteins and microRNAs (miRNAs) were analyzed in the field of epigenetic alterations. Therefore, CRC development results from interactions at many levels between genetic and epigenetic amendments. Furthermore, hereditary cancer syndrome and individual or environmental risk factors should not be ignored. The difficulties in this setting are addressed to understand the molecular basis of individual susceptibility to CRC and to determine the roles of genetic and epigenetic alterations, in order to yield more effective prevention strategies in CRC patients and directing their treatment. This review summarizes the most investigated biomolecular pathways involved in CRC pathogenesis, their role as biomarkers for early CRC diagnosis and their possible use to stratify susceptible patients into appropriate screening or surveillance programs.read more
Citations
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Journal ArticleDOI
Colorectal Cancer from Molecular Pathways to Gene Therapy
Christoforos Kosmidis,Paul Zarogoulidis,George Efthimidis,Sofia Baka,Christoforos Efthimiadis,Ioannis Tzitzikas,Nikolaos V. Michalopoulos,Konstantinos Sapalidis,Yan-Gao Man,Isaak Kesisoglou +9 more
TL;DR: The molecular pathways of CRC are presented and novel gene therapy approaches are discussed to discuss novel gene Therapy approaches for colorectal cancer treatment and prevention.
Journal ArticleDOI
Prognostic significance of CpG island methylator phenotype in colorectal cancer.
TL;DR: Investigating the MSI and CIMP status in Korean colon cancer patients except many rectal cancer patients, and examined their correlation with clinicopathological features including survival showed that regardless of the MSI status, CIMp-high colon cancer was associated with a poor survival outcome, and colon cancer with CimP-high/MSI-negative in subgroup analysis showed apoor survival outcome.
Journal ArticleDOI
Can hypoxia-inducible factor-1α overexpression discriminate human colorectal cancers with different microsatellite instability?
Zahra Arabsorkhi,Hossein Sadeghi,Ehsan Gharib,Leili Rejali,Hamid Asadzadeh-Aghdaei,Ehsan Nazemalhosseini-Mojarad +5 more
TL;DR: In this paper, the authors investigated the usefulness of hypoxia-inducible factor-1α (HIF1α) expression to discriminate high-frequency microsatellite instability (MSI-H) colorectal cancers (CRCs) are different from low-frequency MSI-L and micro-satellite stable (MSS) CRCs.
Dissertation
Scoping for RNA biomarkers in colorectal cancer
TL;DR: This paper aims to provide a history of the field and some of the techniques used in its development, as well as some of its subsequent publications, to help clarify its origins and aims.
Journal ArticleDOI
Effects of glycolysis and polyamine predation on intestinal epithelial barrier in colorectal cancer
TL;DR: It is found that with the increase of HIF1 gene expression, tumor growth was promoted and intestinal mucosal permeability was increased, and the damage of intestinal mucosa was alleviated after supplementation of exogenous polyamines.
References
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