Journal ArticleDOI
Follicular dendritic cells restrict interleukin-4 availability in germinal centers and foster memory B cell generation
Lihui Duan,Dan Liu,Hsin Chen,Michelle A. Mintz,Marissa Y. Chou,Dmitri I. Kotov,Ying Xu,Jinping An,Brian J. Laidlaw,Jason G. Cyster +9 more
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TLDR
In this article, the authors examined the contribution of interleukin (IL)-4 on B cell fate decisions in the germinal centers (GCs) and identified a subset of light zone GC B cells expressing high IL-4 receptor-a (IL4Ra) and CD23 and lacking a Myc-associated signature.About:
This article is published in Immunity.The article was published on 2021-10-12. It has received 27 citations till now. The article focuses on the topics: Memory B cell & Follicular dendritic cells.read more
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Targeting TFH cells in human diseases and vaccination: rationale and practice
TL;DR: Follicular helper T (TFH) cells support germinal center formation and regulate clonal selection and differentiation of memory and antibody-secreting B cells, thus controlling antibody affinity maturation and memory.
Journal ArticleDOI
Competition for refuelling rather than cyclic re-entry initiation evident in germinal centers
TL;DR: Germinal center B cells compete to be refueled by T cells but not for cyclic reentry initiation during affinity maturation, which may contribute to permitting cells of different competencies to be sustained alongside each other and allow T cell support to be provided across a dynamic range commensurate with affinity.
Journal ArticleDOI
Viral infection engenders bona fide and bystander subsets of lung-resident memory B cells through a permissive mechanism
Claude Grégoire,Lionel Spinelli,Sergio Villazala-Merino,Laurine Gil,María Pía Holgado,Myriam Moussa,Chuang Dong,Ana Zarubica,Mathieu Fallet,Jean-Marc Navarro,Bernard Malissen,Pierre Milpied,Mauro Gaya +12 more
TL;DR: In this paper , the authors combined influenza and SARS-CoV-2 infection with fluorescent-reporter mice to identify lung resident memory B cells (MBCs) regardless of antigen specificity.
Journal ArticleDOI
Comprehensive analysis of human IL‐4 receptor subunits shows compartmentalization in steady state and dupilumab treatment
Lukas E. M. Heeb,Onur Boyman +1 more
TL;DR: In this article , the pathomechanism of atopic diseases demonstrated a pivotal role of the cytokines interleukin-4 (IL•4) and IL•13, which has spurred the development of tailored therapeutics targeting their common IL•4 receptor (IL−4R).
Posted ContentDOI
A Distinct Phenotype of Polarized Memory B cell holds IgE Memory
Joshua Kong,Niels Peter Hell Knudsen,Allyssa Phelps,Kelly Bruton,Ilka Hoof,Gitte Lund,Danielle Della Libera,Anders Lund,Lars Harder Christensen,David R. Glass,Tina D. Walker,Allison Fang,Susan Waserman,Manel Jordana,Peter S. Andersen +14 more
TL;DR: In this paper , a population of type 2 polarized memory B cells (MBC2s) were identified as the primary reservoir of IgE memory, which is beneficial in protection against venoms and helminths.
References
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Journal ArticleDOI
Differing Activities of Homeostatic Chemokines CCL19, CCL21, and CXCL12 in Lymphocyte and Dendritic Cell Recruitment and Lymphoid Neogenesis
Sanjiv A. Luther,Afshin Bidgol,Diana C. Hargreaves,Andrea Schmidt,Ying Xu,Jyothi Paniyadi,Mehrdad Matloubian,Jason G. Cyster +7 more
TL;DR: It is shown that ectopic expression in pancreatic islets of CCL19 leads to small infiltrates composed of lymphocytes and dendritic cells and containing high endothelial venules and stromal cells, and it is indicated that LTα1β2 may function downstream of C CL21, CCL21, and IL-2 family cytokines in normal and pathological lymphoid tissue development.
Journal ArticleDOI
Plasma Cell Ontogeny Defined by Quantitative Changes in Blimp-1 Expression
Axel Kallies,Jhagvaral Hasbold,David M. Tarlinton,Wendy Dietrich,Lynn M. Corcoran,Philip D. Hodgkin,Stephen L. Nutt +6 more
TL;DR: Analysis of in vivo ASCs induced by immunization reveals a developmental pathway in which increasing levels of Blimp-1 expression define developmental stages of plasma cell differentiation that have many phenotypic and molecular correlates.
Journal ArticleDOI
Human recombinant interleukin 4 induces Fc epsilon receptors (CD23) on normal human B lymphocytes.
Thierry Defrance,J P Aubry,Françoise Rousset,Béatrice Vanbervliet,J Y Bonnefoy,Naoko Arai,Y Takebe,T Yokota,F Lee,Ken-ichi Arai +9 more
TL;DR: Fc epsilon RL/CD23 induction is specific for IL-4 since IL-1 alpha, IL-2, IFN-gamma, B cell-derived B cell growth factor (BCGF), and a low-molecular-weight BCGF were ineffective.
Journal ArticleDOI
T cells use two directionally distinct pathways for cytokine secretion.
Morgan Huse,Björn F. Lillemeier,Michael S. Kuhns,Daniel S. Chen,Daniel S. Chen,Mark M. Davis,Mark M. Davis +6 more
TL;DR: The data suggest that T helper cells release some cytokines into the immunological synapse to impart specific communication and others multidirectionally to promote inflammation and to establish chemokine gradients.
Journal Article
Anti-cytokine antibodies as carrier proteins. Prolongation of in vivo effects of exogenous cytokines by injection of cytokine-anti-cytokine antibody complexes.
Fred D. Finkelman,Kathleen B. Madden,Suzanne C. Morris,J M Holmes,N Boiani,Ildy M. Katona,C R Maliszewski +6 more
TL;DR: Injection of mice with mixtures of IL-4 and either of two neutralizing anti-IL-4 mAb, at a cytokine/anti-cytokine mAb molar ratio of approximately 2:1, enhances and prolongs in vivo IL- 4 activity, as measured by induction of increased spleen cell Ia expression.