Gene expression profiling of mammary gland development reveals putative roles for death receptors and immune mediators in post-lactational regression
Richard W. E. Clarkson,Matthew T. Wayland,Jennifer M. Lee,Tom C. Freeman,Christine J. Watson +4 more
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TLDR
The sequential induction of distinct apoptosis pathways in involution and the stimulation of immunomodulatory signals are highlighted, which probably suppress the potentially damaging effects of a cellular inflammatory response while maintaining an appropriate antimicrobial and phagocytic environment.Abstract:
Introduction
In order to gain a better understanding of the molecular processes that underlie apoptosis and tissue regression in mammary gland, we undertook a large-scale analysis of transcriptional changes during the mouse mammary pregnancy cycle, with emphasis on the transition from lactation to involution.read more
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Pregnancy-associated breast cancer and metastasis
TL;DR: The mammary microenvironment might become tumour-promoting after pregnancy because of the remodelling of the mammary gland to its pre-pregnant state, and this remodelling, which is associated with pro-inflammatory and wound-healing mechanisms, is proposed to support tumours dissemination.
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Involution of the mouse mammary gland is associated with an immune cascade and an acute-phase response, involving LBP, CD14 and STAT3
Torsten Stein,Joanna S. Morris,Claire R. Davies,Stephen J. Weber-Hall,Marie-Anne Duffy,Victoria J. Heath,Alexandra K. Bell,Roderick K. Ferrier,G. P. Sandilands,Barry A. Gusterson +9 more
TL;DR: Oligonucleotide microarrays are a useful tool for identifying genes that are involved in the complex developmental process of mammary glands involution, with an early acute-phase response that occurs in the mammary gland itself and resembles a wound healing process.
Journal ArticleDOI
Postpartum mammary gland involution drives progression of ductal carcinoma in situ through collagen and COX-2
Traci R. Lyons,Jenean O'Brien,Virginia F. Borges,Virginia F. Borges,Matthew W. Conklin,Patricia J. Keely,Kevin W. Eliceiri,Andriy Marusyk,Aik Choon Tan,Aik Choon Tan,Pepper Schedin,Pepper Schedin +11 more
TL;DR: A mouse model of postpartum breast cancer that identifies mammary gland involution as a driving force of tumor progression is described and data support further research to determine whether women at high risk for postpartums breast cancer would benefit from treatment with nonsteroidal anti-inflammatory drugs (NSAIDs) during post partum involution.
Journal ArticleDOI
KEGG-PATH: Kyoto encyclopedia of genes and genomes-based pathway analysis using a path analysis model
TL;DR: A path analysis model (KEGG-PATH) is developed to subdivide the total effect of each K EGG pathway into the direct effect and indirect effect by taking into account not only each KEGG pathway itself, but also the correlation with its related pathways.
Journal ArticleDOI
Stat3 controls lysosomal-mediated cell death in vivo
Peter A. Kreuzaler,Anna Staniszewska,Wenjing Li,Nader Omidvar,Blandine Kedjouar,James Turkson,Valeria Poli,Richard A. Flavell,Richard W. E. Clarkson,Christine J. Watson +9 more
TL;DR: It is shown that the physiological process of post-lactational regression of the mammary gland is accomplished through a non-classical, lysosomal-mediated pathway of cell death, which requires Stat3, which upregulates the expression of lysOSomal proteases cathepsin B and L, while downregulating their endogenous inhibitor Spi2A.
References
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Gene Ontology: tool for the unification of biology
M Ashburner,Catherine A. Ball,Judith A. Blake,David Botstein,Heather Butler,J. M. Cherry,Allan Peter Davis,Kara Dolinski,Selina S. Dwight,J.T. Eppig,Midori A. Harris,David P. Hill,Laurie Issel-Tarver,Andrew Kasarskis,Suzanna E. Lewis,John C. Matese,Joel E. Richardson,M. Ringwald,Gerald M. Rubin,Gavin Sherlock +19 more
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Andrew Devitt,Andrew Devitt,Odette D. Moffatt,Odette D. Moffatt,Chandra Raykundalia,J. Donald Capra,David Simmons,Christopher D. Gregory,Christopher D. Gregory +8 more
TL;DR: Results indicate that clearance of apoptotic cells is mediated by a receptor whose interactions with ‘non-self’ components (LPS) and ‘self” components (apoptotic cells) produce distinct macrophage responses.