Journal ArticleDOI
Genetic variants within the dopaminergic system interact to modulate endocrine stress reactivity and recovery.
Nina Alexander,Roman Osinsky,Eva Mueller,Anja Schmitz,Sarah Guenthert,Yvonne Kuepper,Juergen Hennig +6 more
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TLDR
The results indicate a crucial role of functional genetic variants within the dopaminergic system in the modulation of HPA-axis response patterns and highlight the need to investigate combined effects of specific candidate genes on stress-related endophenotypes.About:
This article is published in Behavioural Brain Research.The article was published on 2011-01-01. It has received 46 citations till now. The article focuses on the topics: Catechol-O-methyl transferase & Dopaminergic.read more
Citations
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The Adaptive Calibration Model of stress responsivity.
TL;DR: The Adaptive Calibration Model is presented, an evolutionary-developmental theory of individual differences in the functioning of the stress response system that extends the theory of biological sensitivity to context (BSC) and provides an integrative framework for future research in the field.
Journal ArticleDOI
Overlapping Chronic Pain Conditions: Implications for Diagnosis and Classification.
William Maixner,William Maixner,Roger B. Fillingim,David R. Williams,Shad B. Smith,Shad B. Smith,Gary D. Slade +6 more
TL;DR: This brief review describes the concept of COPCs and the putative mechanisms underlying COPCs, a mechanism-based heuristic model is presented and current knowledge and evidence for COPCs are presented and a set of recommendations are provided to advance the understanding of COPs.
Journal ArticleDOI
An Evolutionary Life History Framework for Psychopathology
TL;DR: In this paper, the authors outline a general framework for the evolutionary analysis of mental disorders based on the concepts of life history theory and synthesize and extend a large body of work showing that individual differences in life history strategy set the stage for the development of psychopathology.
Journal ArticleDOI
Genetics of dopamine receptors and drug addiction
Philip Gorwood,Philip Gorwood,Yann Le Strat,Nicolas Ramoz,Caroline Dubertret,J. M. Moalic,Michel Simonneau,Michel Simonneau +7 more
TL;DR: In the context of subsequent genome-wide association (GWAS) research and post-GWAS investigations, the authors summarize the novel data that link genes encoding molecules involved in the dopaminergic system (dopamine receptors, transporter and enzymes in charge of its metabolism) to drug addiction.
Journal ArticleDOI
Fetal programming by maternal stress: Insights from a conflict perspective.
TL;DR: Fetal programming; Genomic imprinting; HPA axis; Maternal effects; Parent-offspring conflict; Placental hormones; Pregnancy; Prenatal conflict;
References
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Journal ArticleDOI
Acute stressors and cortisol responses: a theoretical integration and synthesis of laboratory research.
TL;DR: Motivated performance tasks elicited cortisol responses if they were uncontrollable or characterized by social-evaluative threat (task performance could be negatively judged by others), when methodological factors and other stressor characteristics were controlled for.
Journal ArticleDOI
Human catechol-O-methyltransferase pharmacogenetics: description of a functional polymorphism and its potential application to neuropsychiatric disorders.
Herbert M. Lachman,Demitri F. Papolos,Takuya Saito,Yue Min Yu,Carol L. Szumlanski,Richard M. Weinshilboum +5 more
TL;DR: The identification of a gentic marker associated with significant alterations in enzyme activity will facilitate the analysis of a possible role for the COMT gene in neuropsychiatric conditions in which abnormalities in catecholamine neurotransmission are believed to occur.
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Differential Effect of Stress on In Vivo Dopamine Release in Striatum, Nucleus Accumbens, and Medial Frontal Cortex
TL;DR: Microdialysis was used to assess extracellular dopamine in striatum, nucleus accumbens, and medial frontal cortex of unanesthetized rats both under resting conditions and in response to intermittent tail‐shock stress, providing direct in vivo evidence for the global activation of dopaminergic systems by stress.
Journal ArticleDOI
COMT val158met Genotype Affects µ-Opioid Neurotransmitter Responses to a Pain Stressor
Jon Kar Zubieta,Mary M. Heitzeg,Yolanda R. Smith,Joshua A. Bueller,Ke Xu,Yanjun Xu,Robert A. Koeppe,Christian S. Stohler,David Goldman +8 more
TL;DR: Individuals homozygous for themet158 allele of the catechol-O-methyltransferase (COMT) polymorphism showed diminished regional μ-opioid system responses to pain compared with heterozygotes, and these effects were accompanied by higher sensory and affective ratings of pain and a more negative internal affective state.
Journal ArticleDOI
Selective activation of mesocortical DA system by stress.
TL;DR: The results suggest that the mesocortical DA system is selectively activated by this stress induced by electric foot shocks, and the antipsychotic effects of neuroleptics are in part related to the blockade of postsynaptic DA receptors localised in areas innervated by the mesolimbic and mesocORTical DA systems.
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