Journal ArticleDOI
Genome Mining-Driven Discovery of 5-Methylorsellinate-Derived Meroterpenoids from Aspergillus funiculosus.
Dexiu Yan,Yudai Matsuda +1 more
TLDR
In the fungus Aspergillus funiculosus CBS 11656 as discussed by the authors, the discovery of four new meroterpenoids (funiculolides A-D (1-4) derived from the aromatic polyketide 5-methylorsellinic acid (5-MOA) was reported.About:
This article is published in Organic Letters.The article was published on 2021-04-16. It has received 13 citations till now. The article focuses on the topics: Polyketide & Heterologous expression.read more
Citations
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Aspcandine: A Pyrrolobenzazepine Alkaloid Synthesized by a Fungal Nonribosomal Peptide Synthetase-Polyketide Synthase Hybrid.
TL;DR: Characterization of an orphan biosynthetic gene cluster found in the fungus Aspergillus candidus CBS 102.13 resulted in the discovery of a pyrrolobenzazepine alkaloid, aspcandine, which is synthesized by the nonribosomal peptide synthetase-polyketide synthase hybrid AcdB, which unusually incorporates 3-hydroxy-l-kynurenine as a building block.
Journal ArticleDOI
Discovery of branching meroterpenoid biosynthetic pathways in Aspergillus insuetus: involvement of two terpene cyclases with distinct cyclization modes
Jia Tang,Yudai Matsuda +1 more
TL;DR: The tailoring enzymes encoded by the two clusters, collectively obtained 17 new meroterpenoids, and successfully proposed biosynthetic routes leading to apparent end products of both pathways are characterized.
Journal ArticleDOI
Classifying natural products from plants, fungi or bacteria using the COCONUT database and machine learning.
TL;DR: In this paper, a support vector machine (SVM) trained with MAP4 correctly assigned the origin for 94% of plant, 89% of fungal, and 89% bacterial NPs in this subset.
Journal ArticleDOI
Application of Gene Knockout and Heterologous Expression Strategy in Fungal Secondary Metabolites Biosynthesis
TL;DR: Zhang et al. as mentioned in this paper summarized the representative studies on the biosynthesis of fungal secondary metabolites by gene knockout and heterologous expression under the fungal genome mining in the last three years.
Journal ArticleDOI
Genome Mining of α-Pyrone Natural Products from Ascidian-Derived Fungus Amphichorda felina SYSU-MS7908
Siwen Yuan,Ling Chen,Qili Wu,Minghua Jiang,Heng Guo,Zhibo Hu,Senhua Chen,Lan Liu,Zhizeng Gao +8 more
TL;DR: The genome of Amphichorda felina SYSU-MS7908 was sequenced, and the identification of two new α-pyrone derivatives, amphichopyrone A and B, along with a known compound, udagawanone A (3), and anti-inflammatory activities were performed.
References
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Journal ArticleDOI
Biosynthesis of austalide D, a meroterpenoid mycotoxin from Aspergillus ustus
TL;DR: Incorporation of Aspergillus ustus metabolite D and the isolation of the cometabolites austalide J, K, and L indicate its formation via a mixed polyketide–terpenoid biosynthetic pathway.
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Nonheme Iron- and 2-Oxoglutarate-Dependent Dioxygenases in Fungal Meroterpenoid Biosynthesis
TL;DR: This review summarizes the recent progress in research on the non-heme Fe(II)- and 2-oxoglutarate-dependent dioxygenases, which are involved in the biosynthesis of pharmaceutically important fungal meroterpenoids.