Global cancer statistics, 2012
Lindsey A. Torre,Freddie Bray,Rebecca L. Siegel,Jacques Ferlay,Joannie Lortet-Tieulent,Ahmedin Jemal +5 more
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TLDR
A substantial portion of cancer cases and deaths could be prevented by broadly applying effective prevention measures, such as tobacco control, vaccination, and the use of early detection tests.Abstract:
Cancer constitutes an enormous burden on society in more and less economically developed countries alike. The occurrence of cancer is increasing because of the growth and aging of the population, as well as an increasing prevalence of established risk factors such as smoking, overweight, physical inactivity, and changing reproductive patterns associated with urbanization and economic development. Based on GLOBOCAN estimates, about 14.1 million new cancer cases and 8.2 million deaths occurred in 2012 worldwide. Over the years, the burden has shifted to less developed countries, which currently account for about 57% of cases and 65% of cancer deaths worldwide. Lung cancer is the leading cause of cancer death among males in both more and less developed countries, and has surpassed breast cancer as the leading cause of cancer death among females in more developed countries; breast cancer remains the leading cause of cancer death among females in less developed countries. Other leading causes of cancer death in more developed countries include colorectal cancer among males and females and prostate cancer among males. In less developed countries, liver and stomach cancer among males and cervical cancer among females are also leading causes of cancer death. Although incidence rates for all cancers combined are nearly twice as high in more developed than in less developed countries in both males and females, mortality rates are only 8% to 15% higher in more developed countries. This disparity reflects regional differences in the mix of cancers, which is affected by risk factors and detection practices, and/or the availability of treatment. Risk factors associated with the leading causes of cancer death include tobacco use (lung, colorectal, stomach, and liver cancer), overweight/obesity and physical inactivity (breast and colorectal cancer), and infection (liver, stomach, and cervical cancer). A substantial portion of cancer cases and deaths could be prevented by broadly applying effective prevention measures, such as tobacco control, vaccination, and the use of early detection tests.read more
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Hepatic Hippo signaling inhibits protumoural microenvironment to suppress hepatocellular carcinoma
Wantae Kim,Sanjoy K. Khan,Sanjoy K. Khan,Yuchen Liu,Ruoshi Xu,Ruoshi Xu,Ogyi Park,Yong He,Boksik Cha,Bin Gao,Yingzi Yang,Yingzi Yang +11 more
TL;DR: Hippo signalling in hepatocytes maintains normal liver growth by suppressing macrophage infiltration during protumoural microenvironment formation through the inhibition of Yap-dependent Mcp1 expression, providing new targets and strategies to treat HCCs.
Global Health Equity: Cancer Care Outcome Disparities in High-, Middle-, and Low-Income Countries
TL;DR: In this article, the authors focus on health disparities in cancer within and across countries, drawing from examples in Kenya, Brazil, and the United States, and draw basic recommendations from several initiatives and groups that are working on the issue of global cancer disparities.
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Salivary HOTAIR and PVT1 as novel biomarkers for early pancreatic cancer.
Zijun Xie,Xiaoliang Chen,Jian-Zhong Li,Yunwei Guo,Haijiao Li,Xuemei Pan,Jie Jiang,Huiling Liu,Wu Bin +8 more
TL;DR: Salivary HOTAIR and PVT1 show potential as novel non-invasive biomarkers for detecting PC, and were significantly reduced after the curative pancreatectomy.
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Curcumin: the spicy modulator of breast carcinogenesis.
TL;DR: Curcumin exemplifies a promising natural anticancer agent for this purpose and its modulatory effect on the cancer hallmarks should point toward potential scope of future curcumin research in breast cancer.
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Impact of Sarcopenic Obesity on Outcomes in Patients Undergoing Hepatectomy for Hepatocellular Carcinoma.
Atsushi Kobayashi,Toshimi Kaido,Yuhei Hamaguchi,Shinya Okumura,Hisaya Shirai,Siyuan Yao,Naoko Kamo,Shintaro Yagi,Kojiro Taura,Hideaki Okajima,Shinji Uemoto +10 more
TL;DR: Preoperative sarcopenic obesity was an independent risk factor for death and HCC recurrence after hepatectomy for HCC.
References
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Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012.
Jacques Ferlay,Isabelle Soerjomataram,Rajesh Dikshit,Sultan Eser,Colin Mathers,Marise Souto Rebelo,Donald Maxwell Parkin,David Forman,Freddie Bray +8 more
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Book
Cancer Incidence in Five Continents
Freddie Bray,J. Ferlay,Mathieu Laversanne,David H. Brewster,C. Gombe Mbalawa,B. Kohler,Marion Piñeros,Eva Steliarova-Foucher,Rajaraman Swaminathan,Sebastien Antoni,Isabelle Soerjomataram,David Forman +11 more
TL;DR: The aim of this study was to establish a database of histological groups and to provide a level of consistency and quality of data that could be applied in the design of future registries.
Journal ArticleDOI
Reduced lung-cancer mortality with low-dose computed tomographic screening.
Denise R. Aberle,Amanda M. Adams,Christine D. Berg,William C. Black,Jonathan D. Clapp,Richard M. Fagerstrom,Ilana F. Gareen,Constantine Gatsonis,Pamela M. Marcus,JoRean D. Sicks +9 more
TL;DR: Screening with the use of low-dose CT reduces mortality from lung cancer, as compared with the radiography group, and the rate of death from any cause was reduced.