Global cancer statistics, 2012
Lindsey A. Torre,Freddie Bray,Rebecca L. Siegel,Jacques Ferlay,Joannie Lortet-Tieulent,Ahmedin Jemal +5 more
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TLDR
A substantial portion of cancer cases and deaths could be prevented by broadly applying effective prevention measures, such as tobacco control, vaccination, and the use of early detection tests.Abstract:
Cancer constitutes an enormous burden on society in more and less economically developed countries alike. The occurrence of cancer is increasing because of the growth and aging of the population, as well as an increasing prevalence of established risk factors such as smoking, overweight, physical inactivity, and changing reproductive patterns associated with urbanization and economic development. Based on GLOBOCAN estimates, about 14.1 million new cancer cases and 8.2 million deaths occurred in 2012 worldwide. Over the years, the burden has shifted to less developed countries, which currently account for about 57% of cases and 65% of cancer deaths worldwide. Lung cancer is the leading cause of cancer death among males in both more and less developed countries, and has surpassed breast cancer as the leading cause of cancer death among females in more developed countries; breast cancer remains the leading cause of cancer death among females in less developed countries. Other leading causes of cancer death in more developed countries include colorectal cancer among males and females and prostate cancer among males. In less developed countries, liver and stomach cancer among males and cervical cancer among females are also leading causes of cancer death. Although incidence rates for all cancers combined are nearly twice as high in more developed than in less developed countries in both males and females, mortality rates are only 8% to 15% higher in more developed countries. This disparity reflects regional differences in the mix of cancers, which is affected by risk factors and detection practices, and/or the availability of treatment. Risk factors associated with the leading causes of cancer death include tobacco use (lung, colorectal, stomach, and liver cancer), overweight/obesity and physical inactivity (breast and colorectal cancer), and infection (liver, stomach, and cervical cancer). A substantial portion of cancer cases and deaths could be prevented by broadly applying effective prevention measures, such as tobacco control, vaccination, and the use of early detection tests.read more
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METTL14 Suppresses CRC Progression via Regulating N6-Methyladenosine-Dependent Primary miR-375 Processing.
Xiaoxiang Chen,Mu Xu,Xueni Xu,Xueni Xu,Kaixuan Zeng,Kaixuan Zeng,Xiangxiang Liu,Li Sun,Bei Pan,Bangshun He,Yuqin Pan,Huiling Sun,Xin-Yi Xia,Shukui Wang +13 more
TL;DR: It is found that METTL14 was downregulated in CRC tissues and cell lines, and closely correlated with overall survival (OS) and novel insight into m6A modification in CRC progression is provided.
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A Noncoding Regulatory RNAs Network Driven by Circ-CDYL Acts Specifically in the Early Stages Hepatocellular Carcinoma.
Yanping Wei,Yanping Wei,Xin Chen,Chi Liang,Ling Yan,Xin-wei Yang,Xiaofei Ye,Hailing Zhang,Pinghua Yang,Xiuliang Cui,Yibing Ren,Xianglei Xin,Hengyu Li,Ruoyu Wang,Wenjing Wang,Feng Jiang,Suiyi Liu,Jing Ding,Baohua Zhang,Liang Li,Hongyang Wang,Hongyang Wang +21 more
TL;DR: It is demonstrated that circ‐CDYL expression or which combined with HDGF and HIF1AN are both independent markers for discrimination of early stages of HCC with the odds ratios of 1.09 (95% confidence interval [CI], 1.02‐1.17) and 124.26‐1170), respectively.
Journal ArticleDOI
Gene-environment interaction and risk of breast cancer.
TL;DR: It is concluded that associations between the common genetic variants known today and breast cancer risk are only weakly modified by environmental factors, if at all.
Journal ArticleDOI
Cervical cancer in low and middle‑income countries (Review)
Rodney Hull,Mzwandile Mbele,Tshepiso Jan Makhafola,Chindo Hicks,Shao Ming Wang,Rui Manuel Reis,Ravi Mehrotra,Zilungile Mkhize‑Kwitshana,Gibson Kibiki,David O. Bates,Zodwa Dlamini +10 more
TL;DR: Various types of genetic and epigenetic factors that influence the development, progression or suppression of cervical cancer are explored.
Journal ArticleDOI
Population screening and treatment of Helicobacter pylori infection
TL;DR: Economic analyses suggest that eradication of H. pylori as a means of controlling gastric cancer is cost-effective in high-risk populations, and public health authorities have been slow to consider the benefits of population-based screening and treatment as a Means of reducing the morbidity and mortality associated with the infection.
References
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Journal ArticleDOI
Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012.
Jacques Ferlay,Isabelle Soerjomataram,Rajesh Dikshit,Sultan Eser,Colin Mathers,Marise Souto Rebelo,Donald Maxwell Parkin,David Forman,Freddie Bray +8 more
TL;DR: The GLOBOCAN series of the International Agency for Research on Cancer (IARC) as mentioned in this paper provides estimates of the worldwide incidence and mortality from 27 major cancers and for all cancers combined for 2012.
Journal ArticleDOI
IARC Monographs on the Evaluation of Carcinogenic Risks to Humans
TL;DR: This timely monograph is a distillation of knowledge of hepatitis B, C and D, based on a review of 1000 studies by a small group of scientists, and it is concluded that hepatitis D virus cannot be classified as a human carcinogen.
Book
Cancer Incidence in Five Continents
Freddie Bray,J. Ferlay,Mathieu Laversanne,David H. Brewster,C. Gombe Mbalawa,B. Kohler,Marion Piñeros,Eva Steliarova-Foucher,Rajaraman Swaminathan,Sebastien Antoni,Isabelle Soerjomataram,David Forman +11 more
TL;DR: The aim of this study was to establish a database of histological groups and to provide a level of consistency and quality of data that could be applied in the design of future registries.
Journal ArticleDOI
Reduced lung-cancer mortality with low-dose computed tomographic screening.
Denise R. Aberle,Amanda M. Adams,Christine D. Berg,William C. Black,Jonathan D. Clapp,Richard M. Fagerstrom,Ilana F. Gareen,Constantine Gatsonis,Pamela M. Marcus,JoRean D. Sicks +9 more
TL;DR: Screening with the use of low-dose CT reduces mortality from lung cancer, as compared with the radiography group, and the rate of death from any cause was reduced.