Global cancer statistics, 2012
Lindsey A. Torre,Freddie Bray,Rebecca L. Siegel,Jacques Ferlay,Joannie Lortet-Tieulent,Ahmedin Jemal +5 more
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TLDR
A substantial portion of cancer cases and deaths could be prevented by broadly applying effective prevention measures, such as tobacco control, vaccination, and the use of early detection tests.Abstract:
Cancer constitutes an enormous burden on society in more and less economically developed countries alike. The occurrence of cancer is increasing because of the growth and aging of the population, as well as an increasing prevalence of established risk factors such as smoking, overweight, physical inactivity, and changing reproductive patterns associated with urbanization and economic development. Based on GLOBOCAN estimates, about 14.1 million new cancer cases and 8.2 million deaths occurred in 2012 worldwide. Over the years, the burden has shifted to less developed countries, which currently account for about 57% of cases and 65% of cancer deaths worldwide. Lung cancer is the leading cause of cancer death among males in both more and less developed countries, and has surpassed breast cancer as the leading cause of cancer death among females in more developed countries; breast cancer remains the leading cause of cancer death among females in less developed countries. Other leading causes of cancer death in more developed countries include colorectal cancer among males and females and prostate cancer among males. In less developed countries, liver and stomach cancer among males and cervical cancer among females are also leading causes of cancer death. Although incidence rates for all cancers combined are nearly twice as high in more developed than in less developed countries in both males and females, mortality rates are only 8% to 15% higher in more developed countries. This disparity reflects regional differences in the mix of cancers, which is affected by risk factors and detection practices, and/or the availability of treatment. Risk factors associated with the leading causes of cancer death include tobacco use (lung, colorectal, stomach, and liver cancer), overweight/obesity and physical inactivity (breast and colorectal cancer), and infection (liver, stomach, and cervical cancer). A substantial portion of cancer cases and deaths could be prevented by broadly applying effective prevention measures, such as tobacco control, vaccination, and the use of early detection tests.read more
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Circular RNA circFOXO3 promotes prostate cancer progression through sponging miR-29a-3p.
Zhe Kong,Xuechao Wan,Yali Lu,Yingyi Zhang,Yan Huang,Yi Xu,Yajuan Liu,Peiqing Zhao,Xinxin Xiang,Liang Li,Yao Li +10 more
TL;DR: circFOXO3 acts as a miR‐29a‐3p sponge to exhibit oncogenic activity that affects the cell cycle and cell apoptosis in PCa through transcriptional up‐regulation of SLC25A15, and suggests circ FOXO3 could act as promising prostate cancer biomarkers.
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Long non-coding RNA XIST inhibited breast cancer cell growth, migration, and invasion via miR-155/CDX1 axis.
Ruinian Zheng,Shunhuan Lin,Ling Guan,Huiling Yuan,Kejun Liu,Chun Liu,Weibiao Ye,Yuting Liao,Jun Jia,Ruopeng Zhang +9 more
TL;DR: The results suggest that XIST is down-regulated in breast cancer and suppresses breast cancer cell growth, migration, and invasion via the miR-155/CDX1 axis.
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Burden, emotional distress and quality of life among informal caregivers of lung cancer patients: An exploratory study.
TL;DR: Evidence is provided that lung cancer patients and their caregivers should be viewed as a unit in future supportive service models because of the close interrelationships between caregiver and patient health outcomes.
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Laparoscopic and robot-assisted vs open radical prostatectomy for the treatment of localized prostate cancer: a Cochrane systematic review
Dragan Ilic,Susan E. Evans,Christie Allan,Jae Hung Jung,Jae Hung Jung,Declan G. Murphy,Mark Frydenberg +6 more
TL;DR: To determine the effects of laparoscopic radical prostatectomy (LRP), or robot‐assisted radical prostateCTomy (RARP) compared with open radical prostateectomy (ORP) in men with localized prostate cancer, laparoscopy is used as a surrogate for surgery.
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Genome-Wide CRISPR Screen Identifies Regulators of Mitogen-Activated Protein Kinase as Suppressors of Liver Tumors in Mice
Chun-Qing Song,Yingxiang Li,Yingxiang Li,Haiwei Mou,Jill Moore,Angela Park,Yotsawat Pomyen,Soren Hough,Zachary Kennedy,Andrew H. Fischer,Hao Yin,Daniel G. Anderson,Darryl Conte,Lars Zender,Xin Wei Wang,Snorri S. Thorgeirsson,Zhiping Weng,Zhiping Weng,Wen Xue +18 more
TL;DR: This paper performed a genome-wide screen to identify suppressors of liver tumor formation in mice, using CRISPR-mediated genome editing, and identified Nf1, Plxnb1, Flrt2, and B9d1 as suppressors.
References
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Jacques Ferlay,Isabelle Soerjomataram,Rajesh Dikshit,Sultan Eser,Colin Mathers,Marise Souto Rebelo,Donald Maxwell Parkin,David Forman,Freddie Bray +8 more
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Book
Cancer Incidence in Five Continents
Freddie Bray,J. Ferlay,Mathieu Laversanne,David H. Brewster,C. Gombe Mbalawa,B. Kohler,Marion Piñeros,Eva Steliarova-Foucher,Rajaraman Swaminathan,Sebastien Antoni,Isabelle Soerjomataram,David Forman +11 more
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Denise R. Aberle,Amanda M. Adams,Christine D. Berg,William C. Black,Jonathan D. Clapp,Richard M. Fagerstrom,Ilana F. Gareen,Constantine Gatsonis,Pamela M. Marcus,JoRean D. Sicks +9 more
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