Global cancer statistics, 2012
Lindsey A. Torre,Freddie Bray,Rebecca L. Siegel,Jacques Ferlay,Joannie Lortet-Tieulent,Ahmedin Jemal +5 more
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TLDR
A substantial portion of cancer cases and deaths could be prevented by broadly applying effective prevention measures, such as tobacco control, vaccination, and the use of early detection tests.Abstract:
Cancer constitutes an enormous burden on society in more and less economically developed countries alike. The occurrence of cancer is increasing because of the growth and aging of the population, as well as an increasing prevalence of established risk factors such as smoking, overweight, physical inactivity, and changing reproductive patterns associated with urbanization and economic development. Based on GLOBOCAN estimates, about 14.1 million new cancer cases and 8.2 million deaths occurred in 2012 worldwide. Over the years, the burden has shifted to less developed countries, which currently account for about 57% of cases and 65% of cancer deaths worldwide. Lung cancer is the leading cause of cancer death among males in both more and less developed countries, and has surpassed breast cancer as the leading cause of cancer death among females in more developed countries; breast cancer remains the leading cause of cancer death among females in less developed countries. Other leading causes of cancer death in more developed countries include colorectal cancer among males and females and prostate cancer among males. In less developed countries, liver and stomach cancer among males and cervical cancer among females are also leading causes of cancer death. Although incidence rates for all cancers combined are nearly twice as high in more developed than in less developed countries in both males and females, mortality rates are only 8% to 15% higher in more developed countries. This disparity reflects regional differences in the mix of cancers, which is affected by risk factors and detection practices, and/or the availability of treatment. Risk factors associated with the leading causes of cancer death include tobacco use (lung, colorectal, stomach, and liver cancer), overweight/obesity and physical inactivity (breast and colorectal cancer), and infection (liver, stomach, and cervical cancer). A substantial portion of cancer cases and deaths could be prevented by broadly applying effective prevention measures, such as tobacco control, vaccination, and the use of early detection tests.read more
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Visceral Adiposity and Sarcopenic Visceral Obesity are Associated with Poor Prognosis After Resection of Pancreatic Cancer
Shinya Okumura,Toshimi Kaido,Yuhei Hamaguchi,Atsushi Kobayashi,Hisaya Shirai,Siyuan Yao,Shintaro Yagi,Naoko Kamo,Etsuro Hatano,Hideaki Okajima,Kyoichi Takaori,Shinji Uemoto +11 more
TL;DR: Visceral adiposity and sarcopenic visceral obesity, as well as low muscle mass and quality, were closely associated with mortality and recurrence after resection of pancreatic cancer.
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FGFR2 Promotes Expression of PD-L1 in Colorectal Cancer via the JAK/STAT3 Signaling Pathway.
TL;DR: A novel mechanism of PD-L1 expression in CRC is revealed, thus providing a theoretical basis for reversing the immune tolerance of FGFR2 overexpression in CRC.
Journal ArticleDOI
Six Serum-Based miRNAs as Potential Diagnostic Biomarkers for Gastric Cancer
Zebo Huang,Danxia Zhu,Lirong Wu,Mingfeng He,Xin Zhou,Lan Zhang,Huo Zhang,Weiwei Wang,Jun Zhu,Wenfang Cheng,Yan Chen,Yong Fan,Lian-Wen Qi,Yin Yin,Wei Zhu,Yongqian Shu,Ping Liu +16 more
TL;DR: These findings provide a novel serum miRNA signature for gastric cancer diagnosis, and will serve as the basis of the application of circulating miRNAs in clinical for the detection of Gastric cancer in the future.
Journal ArticleDOI
Immunomarker Support Vector Machine Classifier for Prediction of Gastric Cancer Survival and Adjuvant Chemotherapeutic Benefit
Yuming Jiang,Yuming Jiang,Jingjing Xie,Zhen Han,Wei Liu,Sujuan Xi,Lei Huang,Weicai Huang,Tian Lin,Liying Zhao,Yanfeng Hu,Jiang Yu,Qi Zhang,Tuanjie Li,Tuanjie Li,Shirong Cai,Guoxin Li +16 more
TL;DR: A classifier was constructed to predict prognosis and identify a subset of patients who can benefit from adjuvant chemotherapy and had higher predictive accuracy for OS and DFS than TNM stage and can complement the prognostic value of the TNM staging system.
Journal ArticleDOI
Prognostic Implications of Autophagy-Associated Gene Signatures in Non-Small Cell Lung Cancer
TL;DR: A novel autophagy-associated gene signature is constructed and verified that could improve the individualized outcome prediction in NSCLC and constructed a clinical nomogram with a concordance index of 0.71 to predict the survival possibility ofNSCLC patients by integrating clinical characteristics and the autophagic gene signature.
References
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Journal ArticleDOI
Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012.
Jacques Ferlay,Isabelle Soerjomataram,Rajesh Dikshit,Sultan Eser,Colin Mathers,Marise Souto Rebelo,Donald Maxwell Parkin,David Forman,Freddie Bray +8 more
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Journal ArticleDOI
IARC Monographs on the Evaluation of Carcinogenic Risks to Humans
TL;DR: This timely monograph is a distillation of knowledge of hepatitis B, C and D, based on a review of 1000 studies by a small group of scientists, and it is concluded that hepatitis D virus cannot be classified as a human carcinogen.
Book
Cancer Incidence in Five Continents
Freddie Bray,J. Ferlay,Mathieu Laversanne,David H. Brewster,C. Gombe Mbalawa,B. Kohler,Marion Piñeros,Eva Steliarova-Foucher,Rajaraman Swaminathan,Sebastien Antoni,Isabelle Soerjomataram,David Forman +11 more
TL;DR: The aim of this study was to establish a database of histological groups and to provide a level of consistency and quality of data that could be applied in the design of future registries.
Journal ArticleDOI
Reduced lung-cancer mortality with low-dose computed tomographic screening.
Denise R. Aberle,Amanda M. Adams,Christine D. Berg,William C. Black,Jonathan D. Clapp,Richard M. Fagerstrom,Ilana F. Gareen,Constantine Gatsonis,Pamela M. Marcus,JoRean D. Sicks +9 more
TL;DR: Screening with the use of low-dose CT reduces mortality from lung cancer, as compared with the radiography group, and the rate of death from any cause was reduced.