Global cancer statistics, 2012
Lindsey A. Torre,Freddie Bray,Rebecca L. Siegel,Jacques Ferlay,Joannie Lortet-Tieulent,Ahmedin Jemal +5 more
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TLDR
A substantial portion of cancer cases and deaths could be prevented by broadly applying effective prevention measures, such as tobacco control, vaccination, and the use of early detection tests.Abstract:
Cancer constitutes an enormous burden on society in more and less economically developed countries alike. The occurrence of cancer is increasing because of the growth and aging of the population, as well as an increasing prevalence of established risk factors such as smoking, overweight, physical inactivity, and changing reproductive patterns associated with urbanization and economic development. Based on GLOBOCAN estimates, about 14.1 million new cancer cases and 8.2 million deaths occurred in 2012 worldwide. Over the years, the burden has shifted to less developed countries, which currently account for about 57% of cases and 65% of cancer deaths worldwide. Lung cancer is the leading cause of cancer death among males in both more and less developed countries, and has surpassed breast cancer as the leading cause of cancer death among females in more developed countries; breast cancer remains the leading cause of cancer death among females in less developed countries. Other leading causes of cancer death in more developed countries include colorectal cancer among males and females and prostate cancer among males. In less developed countries, liver and stomach cancer among males and cervical cancer among females are also leading causes of cancer death. Although incidence rates for all cancers combined are nearly twice as high in more developed than in less developed countries in both males and females, mortality rates are only 8% to 15% higher in more developed countries. This disparity reflects regional differences in the mix of cancers, which is affected by risk factors and detection practices, and/or the availability of treatment. Risk factors associated with the leading causes of cancer death include tobacco use (lung, colorectal, stomach, and liver cancer), overweight/obesity and physical inactivity (breast and colorectal cancer), and infection (liver, stomach, and cervical cancer). A substantial portion of cancer cases and deaths could be prevented by broadly applying effective prevention measures, such as tobacco control, vaccination, and the use of early detection tests.read more
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Radiomics signature of computed tomography imaging for prediction of survival and chemotherapeutic benefits in gastric cancer.
Yuming Jiang,Chuanli Chen,Jingjing Xie,Wei Wang,Xuefan Zha,Wenbing Lv,Hao Chen,Yanfeng Hu,Tuanjie Li,Jiang Yu,Zhiwei Zhou,Yikai Xu,Guoxin Li +12 more
TL;DR: The newly developed radiomics signature is a powerful predictor of DFS and OS, and it may predict which patients with stage II and III GC benefit from chemotherapy.
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Apatinib: A novel receptor tyrosine kinase inhibitor for the treatment of gastric cancer
Giandomenico Roviello,Giandomenico Roviello,Andrea Ravelli,Andrea Ravelli,Karol Polom,Roberto Petrioli,Luigi Marano,Daniele Marrelli,Franco Roviello,Daniele Generali,Daniele Generali +10 more
TL;DR: In this article, a review of the available data of apatinib, mainly focused on the clinical aspect, in advanced/metastatic gastric cancer is presented, with the focus on the VEGF (vascular endothelial growth factor) expression.
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3D bioprinting: improving in vitro models of metastasis with heterogeneous tumor microenvironments
TL;DR: Recent 3D bioprinting advances that can be used to produce heterogeneous tumor microenvironments for improved physical modeling of cancer metastasis are discussed.
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Comprehensive circular RNA profiling reveals the regulatory role of the circRNA-000911/miR-449a pathway in breast carcinogenesis
TL;DR: The findings indicate that circRNA-000911 plays an anti-oncogenic role in breast cancer and may thus serve as a promising therapeutic target for patients with breast cancer.
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Stellettin B Induces G1 Arrest, Apoptosis and Autophagy in Human Non-small Cell Lung Cancer A549 Cells via Blocking PI3K/Akt/mTOR Pathway
Ran Wang,Qian Zhang,Xin Peng,Chang Zhou,Yuxu Zhong,Xi Chen,Yuling Qiu,Meihua Jin,Min Gong,Dexin Kong +9 more
TL;DR: The isolated stellettin B (Stel B) from marine sponge Jaspis stellifera is isolated, and it is demonstrated that it induced G1 arrest, apoptosis and autophagy at low concentrations in human NSCLC A549 cells, indicating the antitumor potential of Stel B by targeting PI3K/Akt/mTOR pathway.
References
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Jacques Ferlay,Isabelle Soerjomataram,Rajesh Dikshit,Sultan Eser,Colin Mathers,Marise Souto Rebelo,Donald Maxwell Parkin,David Forman,Freddie Bray +8 more
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IARC Monographs on the Evaluation of Carcinogenic Risks to Humans
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Book
Cancer Incidence in Five Continents
Freddie Bray,J. Ferlay,Mathieu Laversanne,David H. Brewster,C. Gombe Mbalawa,B. Kohler,Marion Piñeros,Eva Steliarova-Foucher,Rajaraman Swaminathan,Sebastien Antoni,Isabelle Soerjomataram,David Forman +11 more
TL;DR: The aim of this study was to establish a database of histological groups and to provide a level of consistency and quality of data that could be applied in the design of future registries.
Journal ArticleDOI
Reduced lung-cancer mortality with low-dose computed tomographic screening.
Denise R. Aberle,Amanda M. Adams,Christine D. Berg,William C. Black,Jonathan D. Clapp,Richard M. Fagerstrom,Ilana F. Gareen,Constantine Gatsonis,Pamela M. Marcus,JoRean D. Sicks +9 more
TL;DR: Screening with the use of low-dose CT reduces mortality from lung cancer, as compared with the radiography group, and the rate of death from any cause was reduced.