Global cancer statistics, 2012
Lindsey A. Torre,Freddie Bray,Rebecca L. Siegel,Jacques Ferlay,Joannie Lortet-Tieulent,Ahmedin Jemal +5 more
Reads0
Chats0
TLDR
A substantial portion of cancer cases and deaths could be prevented by broadly applying effective prevention measures, such as tobacco control, vaccination, and the use of early detection tests.Abstract:
Cancer constitutes an enormous burden on society in more and less economically developed countries alike. The occurrence of cancer is increasing because of the growth and aging of the population, as well as an increasing prevalence of established risk factors such as smoking, overweight, physical inactivity, and changing reproductive patterns associated with urbanization and economic development. Based on GLOBOCAN estimates, about 14.1 million new cancer cases and 8.2 million deaths occurred in 2012 worldwide. Over the years, the burden has shifted to less developed countries, which currently account for about 57% of cases and 65% of cancer deaths worldwide. Lung cancer is the leading cause of cancer death among males in both more and less developed countries, and has surpassed breast cancer as the leading cause of cancer death among females in more developed countries; breast cancer remains the leading cause of cancer death among females in less developed countries. Other leading causes of cancer death in more developed countries include colorectal cancer among males and females and prostate cancer among males. In less developed countries, liver and stomach cancer among males and cervical cancer among females are also leading causes of cancer death. Although incidence rates for all cancers combined are nearly twice as high in more developed than in less developed countries in both males and females, mortality rates are only 8% to 15% higher in more developed countries. This disparity reflects regional differences in the mix of cancers, which is affected by risk factors and detection practices, and/or the availability of treatment. Risk factors associated with the leading causes of cancer death include tobacco use (lung, colorectal, stomach, and liver cancer), overweight/obesity and physical inactivity (breast and colorectal cancer), and infection (liver, stomach, and cervical cancer). A substantial portion of cancer cases and deaths could be prevented by broadly applying effective prevention measures, such as tobacco control, vaccination, and the use of early detection tests.read more
Citations
More filters
Journal ArticleDOI
The Versatile Role of microRNA-30a in Human Cancer
TL;DR: Recent research regarding miR-30a is summarized, including its biological function, expression and regulation, especially focusing on its role in cancer development and progression, which may serve as a potential target in the diagnosis and therapy of human cancer.
Journal ArticleDOI
The Roles of Matrix Metalloproteinases and Their Inhibitors in Human Diseases.
Griselda A Cabral-Pacheco,Idalia Garza-Veloz,Claudia Castruita-De la Rosa,Jesus Manuel Ramirez-Acuña,Braulio A Perez-Romero,Jesús F Guerrero-Rodriguez,Nadia Martinez-Avila,Margarita L Martinez-Fierro +7 more
TL;DR: In this article, a review of the role of matrix metalloproteinases (MMPs) and TIMPs in physiological processes and how their abnormal regulation is associated with human diseases is presented.
Journal ArticleDOI
Evaluation of the use of therapeutic peptides for cancer treatment
TL;DR: In this review, strategies used to overcome peptide limitations and to enhance their therapeutic effect will be compared and the use of short cell permeable peptides that interfere and inhibit protein-protein interactions will be evaluated.
Journal ArticleDOI
Prospective Genotyping of Hepatocellular Carcinoma: Clinical Implications of Next Generation Sequencing for Matching Patients to Targeted and Immune Therapies
James J. Harding,Subhiksha Nandakumar,Joshua Armenia,Danny N. Khalil,Melanie Albano,Michele Ly,Jinru Shia,Jaclyn F. Hechtman,Ritika Kundra,Imane El Dika,Richard K. G. Do,Yichao Sun,T. Peter Kingham,Michael I. D’Angelica,Michael F. Berger,David M. Hyman,William R. Jarnagin,David S. Klimstra,Yelena Y. Janjigian,David B. Solit,Nikolaus Schultz,Ghassan K. Abou-Alfa +21 more
TL;DR: Linking NGS to routine clinical care has the potential to identify those patients with HCC likely to benefit from standard systemic therapies and can be used in an investigational context to match patients to genome-directed targeted therapies.
Journal ArticleDOI
Prostate MRI, with or without MRI‐targeted biopsy, and systematic biopsy for detecting prostate cancer
Frankâ€Jan H Drost,Daniël F Osses,Daan Nieboer,Ewout W. Steyerberg,Chris H. Bangma,Monique J. Roobol,Ivo G. Schoots +6 more
TL;DR: The diagnostic accuracy of the index tests MRI only, MRI-targeted biopsy, the MRI pathway and systematic biopsy as compared to template-guidedBiopsy as the reference standard in detecting clinically significant prostate cancer as the target condition was determined.
References
More filters
Journal ArticleDOI
Cancer incidence and mortality worldwide: sources, methods and major patterns in GLOBOCAN 2012.
Jacques Ferlay,Isabelle Soerjomataram,Rajesh Dikshit,Sultan Eser,Colin Mathers,Marise Souto Rebelo,Donald Maxwell Parkin,David Forman,Freddie Bray +8 more
TL;DR: The GLOBOCAN series of the International Agency for Research on Cancer (IARC) as mentioned in this paper provides estimates of the worldwide incidence and mortality from 27 major cancers and for all cancers combined for 2012.
Journal ArticleDOI
IARC Monographs on the Evaluation of Carcinogenic Risks to Humans
TL;DR: This timely monograph is a distillation of knowledge of hepatitis B, C and D, based on a review of 1000 studies by a small group of scientists, and it is concluded that hepatitis D virus cannot be classified as a human carcinogen.
Book
Cancer Incidence in Five Continents
Freddie Bray,J. Ferlay,Mathieu Laversanne,David H. Brewster,C. Gombe Mbalawa,B. Kohler,Marion Piñeros,Eva Steliarova-Foucher,Rajaraman Swaminathan,Sebastien Antoni,Isabelle Soerjomataram,David Forman +11 more
TL;DR: The aim of this study was to establish a database of histological groups and to provide a level of consistency and quality of data that could be applied in the design of future registries.
Journal ArticleDOI
Reduced lung-cancer mortality with low-dose computed tomographic screening.
Denise R. Aberle,Amanda M. Adams,Christine D. Berg,William C. Black,Jonathan D. Clapp,Richard M. Fagerstrom,Ilana F. Gareen,Constantine Gatsonis,Pamela M. Marcus,JoRean D. Sicks +9 more
TL;DR: Screening with the use of low-dose CT reduces mortality from lung cancer, as compared with the radiography group, and the rate of death from any cause was reduced.